Results 61 to 70 of about 135,870 (288)
FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression
Neural Regeneration ResearchAlzheimer’s disease is characterized by deposition of amyloid-β, which forms extracellular neuritic plaques, and accumulation of hyperphosphorylated tau, which aggregates to form intraneuronal neurofibrillary tangles, in the brain. The NLRP3 inflammasome
Jing Yao +7 more
doaj +1 more source
Interleukin-18 mediates cardiac dysfunction induced by western diet independent of obesity and hyperglycemia in the mouse [PDF]
, 2017 Obesity and diabetes are independent risk factors for heart failure and are associated with the consumption of diet rich in saturated fat and sugar, Western diet (WD), known to induce cardiac dysfunction in the mouse through incompletely characterized ...
Abbate, A. +7 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.Our study showed that human primary gingival fibroblast–derived microvesicles on nano‐engineered titanium implants promote early osseointegration and soft‐tissue attachment in vivo. ABSTRACT Titanium dental implants require both reliable osseointegration and peri‐implant soft tissue seal formation to ensure long‐term success. While osseointegration has
Pingping Han +10 more
wiley +1 more source
The Role of NLRP3 Inflammasomes in Trained Immunity
Frontiers in Bioscience-Landmark, 2023 Inflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis.
Gilyoung Lee +3 more
doaj +1 more source
Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease [PDF]
, 2018 The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN),
Boza-Serrano, Antonio, +11 more
core +1 more source
The PLK1 and NLRP3 interactome in NLRP3 inflammasome activation
, 2021 Excessive activation of the NLRP3 inflammasome is involved in sterile inflammation in multiple chronic diseases such as atherosclerosis, gout, type 2 diabetes or Alzheimer’s disease. However, current treatment strategies using generic targeting of IL-1, the end product of multiple inflammasome pathways, can increase the rate of opportunistic infection.
openaire +1 more source
Cellular localization of NLRP3 inflammasome [PDF]
Protein & Cell, 2013 AbstractInflammasome is a large protein complex activated upon cellular stress or microbial infection, which triggers maturation of pro-inflammatory cytokines interleukin-1β and interleukin-18 through caspase-1 activation. Nod-like receptor family protein 3 (NLRP3) is the most characterized inflammasome activated by various stimuli.
Yan, Wang +5 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He +4 more
wiley +1 more source
ACTIVATION MECHANISMS OF GUT-ASSOCIATED LYMPHOID TISSUE UNDER CHRONIC SOCIAL STRESS CONDITIONS
Медицинская иммунология, 2015 Stress-induced immune disregulation is a risk factor of autoimmune and inflammatory diseases, but, so far, the mechanisms for this effect are not fully known. Expression levels of specific mRNAs were assessed in gut-associated lymphoid tissue (GALT) from
A. M. Kamyshnyi, I. A. Topol
doaj +1 more source
Upsala Journal of Medical Sciences, 2021 Background: In obstructive sleep apnea (OSA), recurrent upper airway obstruction and apnea/hypopnea episodes result in endothelial dysfunction, which leads to the release of many proinflammatory cytokines and reactive oxygen species (ROS).
Buğra Kerget +4 more
doaj +1 more source