Results 61 to 70 of about 162,609 (336)

Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt

Drug Design, Development and Therapy, 2022
Muhammad Riaz,1 Lina Tariq Al Kury,2 Noreen Atzaz,3 Abdullah Alattar,4 Reem Alshaman,4 Fawad ali Shah,1 Shupeng Li5 1Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan; 2Department of Natural and Health ...
Riaz M, Al Kury LT, Atzaz N, Alattar A, Alshaman R, Shah FA, Li S   +6 more
doaj  

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Protective effects of CY-09 and astaxanthin on NaIO3-induced photoreceptor inflammation via the NLRP3/autophagy pathway [PDF]

International Journal of Ophthalmology
AIM: To study the effect of the NLRP3/autophagy pathway on the photoreceptor inflammatory response and the protective mechanism of CY-09 and astaxanthin (AST).
Xiao-Li Wang, Yun-Xia Gao, Qiong-Zhen Yuan, Ming Zhang   +3 more
doaj   +1 more source

Functional deficits precede structural lesions in mice with high-fat diet-induced diabetic retinopathy [PDF]

, 2016
Obesity predisposes to human type 2 diabetes, the most common cause of diabetic retinopathy. To determine if high-fat diet–induced diabetes in mice can model retinal disease, we weaned mice to chow or a high-fat diet and tested the hypothesis that diet ...
Bligard, Gregory W, Lukasiewicz, Peter, Rajagopal, Rithwick, Semenkovich, Clay F, Yin, Li, Zhang, Sheng   +5 more
core   +2 more sources

How location and cellular signaling combine to activate the NLRP3 inflammasome

Cellular & Molecular Immunology, 2022
NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and sterile inflammation.
Anil Akbal, Alesja Dernst, M. Lovotti, M. Mangan, R. McManus, E. Latz   +5 more
semanticscholar   +1 more source

Elevated Level of DNA Damage and Impaired Repair of Oxidative DNA Damage in Patients with Recurrent Depressive Disorder [PDF]

, 2015
Background: Depressive disorder (DD), including recurrent DD (rDD), is a severe psychological disease, which affects a large percentage of the world population.
Bielecka-Kowalska, Anna, Czarny, Piotr, Gałecki, Piotr, Kacperska, Dagmara, Kawczyńska, Daria, Kwiatkowski, Dominik, Orzechowska, Agata, Szemraj, Janusz, Talarowska, Monika, Śliwiński, Tomasz   +9 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

NLRP3 Regulated CXCL12 Expression in Acute Neutrophilic Lung Injury

Journal of Inflammation Research, 2020
Yanwen Peng,1 Qiongli Wu,2 Hao Tang,3 Jingrou Chen,1 Qili Wu,1 Xiaofeng Yuan,4 Shiqiu Xiong,5 Yujin Ye,6 Haijin Lv7 1The Biotherapy Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, People’s Republic of China ...
Peng Y, Wu Q, Tang H, Chen J, Wu Q, Yuan X, Xiong S, Ye Y, Lv H   +8 more
doaj  

Interplay Between NLRP3 Inflammasome and Autophagy

Frontiers in Immunology, 2020
The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators (DAMPs).
Monika Biasizzo, N. Kopitar-Jerala
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source