Results 81 to 90 of about 120,852 (299)
, 2020 [[abstract]]發炎體 (Inflammasome) 是一組複雜的炎症相關蛋白質家族，其參與調控免疫活化與炎症反應。挫傷為主要的運動傷害之一，由於發炎體在肌肉挫傷中扮演的角色仍未明且NLRP3 (NLR family pyrin domain containing 3) 發炎體在發炎體家族中極為重要，因此，本研究使用NLRP3 (Knockout, KO) 基因剔除鼠來探討發炎體在肌肉挫傷中之角色。試驗使用重物自由落體造成腓腸肌的肌肉挫傷 (Mass-drop injury, MDI ...
Chiu, Liang-Ju, 邱亮儒
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Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Acta Biomedica ScientificaBackground. The pathogenetic mechanism of the development of a prolonged systemic inflammatory process in patients who have suffered a new coronavirus infection remains an urgent problem.
T. G. Lobova, T. I. Vitkina
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Advanced Science, EarlyView.IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia +8 more
wiley +1 more source
Open MedicineThis study investigates the effects of subclinical doses of esketamine on serum NLRP3 levels and early cognitive dysfunction in elderly ischemic stroke patients after neurointerventional procedures under general anesthesia.
Wang Lang, Ma Baoxin, Zhang Jianping
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Pharmacological Modulation of NLRP3: From Therapy Personalization to Innovative Drugs
Frontiers in Bioscience-LandmarkThe nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome is a multiprotein complex fundamental for the secretion of pro-inflammatory cytokines during the innate immune response.
Giulia Zudeh +4 more
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Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives
, 2015 Ema Ozaki,1 Matthew Campbell,1 Sarah L Doyle2,3 1Department of Genetics, 2Department of Clinical Medicine, School of Medicine, Trinity College Dublin, 3National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin ...
Campbell M, Doyle SL, Ozaki E
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Introduction Recently, NLR family pyrin domain containing 3 (NLRP3) and pyroptosis have been reported to be involved in traumatic brain injury-induced acute lung injury (TBI-ALI).
Yiqin Yu +8 more
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Advanced Science, EarlyView.Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan +16 more
wiley +1 more source
PKA Has the Gall to Oppose NLRP3.
, 2016 The involvement of the NLRP3 inflammasome in inflammatory diseases has generated interest in identifying endogenous mechanisms that inhibit NLRP3. In this issue of Immunity, Guo et al.
Groß, Christina J;Groß, Olaf
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