Results 91 to 100 of about 120,852 (299)

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

Inflammasome-Driven Cardiac Fibrosis in Cardiometabolic Disease and Arrhythmias: Mechanisms, Biomarkers, and Therapeutic Targets

Frontiers in Bioscience-Landmark
Chronic low-grade inflammation and maladaptive extracellular matrix remodeling co-evolve across atrial fibrillation, heart failure phenotypes, diabetic cardiomyopathy, and aortic valve stenosis. Emerging data implicate inflammasome signaling-particularly
Konstantinos Grigoriou, Vasileios Lamprou, Antonios P Antoniadis, Panagiotis Theofilis, Panagiotis Iliakis, Nikolaos Ktenopoulos, Anastasios Apostolos, Athina Nasoufidou, Barbara Fyntanidou, Efstratios Karagiannidis, Nikolaos Fragakis, Dimitrios Patoulias, Paschalis Karakasis   +12 more
doaj   +1 more source

Targeting Cannabinoid 1 Receptor in Macrophages Alleviates Psoriatic Skin Inflammation Through the AUF1-NLRP3 Axis. [PDF]

Adv Sci (Weinh)
Macrophage CB1R emerges as a key driver of psoriatic inflammation by suppressing AUF1‐mediated post‐transcriptional control of NLRP3. CB1R inhibition restores AUF1‐dependent NLRP3 mRNA decay, restrains inflammasome activation, and alleviates psoriasis‐like inflammation.
Choi H, Han S, Kim J, Han JH, Kim E, Heo Y, Lee M, Lee J, You H, Lee S, Han SH, Yoon I, Anjeon S, Kang H, Ryu S, Park HJ, Kim E, Bang CH, Lee JH, Egan JM, Kim JW, Lee EK, Kim W.   +22 more
europepmc   +2 more sources

NLRP3-dependent and -independent processing of interleukin (IL)-1β in active ulcerative colitis

, 2019
A contributing factor in the development of ulcerative colitis (UC) and Crohn’s disease (CD) is the disruption of innate and adaptive signaling pathways due to aberrant cytokine production.
Veldhuis, M (15513056), Mitchell, B (15509024), Nicole Ranson (14747524), Rajaraman Eri (14736106), Anthony Cook (14734198), Fanning, S (15677972), Kunde, D (15562145)   +6 more
core  

RORy regulates the NLRP3 inflammasome [PDF]

, 2019
RAR-related orphan receptor (ROR) is a nuclear receptor that plays an essential role in the development of T helper 17 (Th17) cells of the adaptive immune system.
Murray, Meghan H., Avdagic, Amer, Billon, Cyrielle, Burris, Thomas P.   +3 more
core   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

Inflammasomes: a novel potential biomarker for chronic heart failure (review)

Рациональная фармакотерапия в кардиологии
The objective of this review is to analyze publications about biochemical studies of inflammasome profile proteins in patients with heart failure as diagnostic markers and promising therapeutic targets.
Yu. S. Timofeev, V. A. Metelskaya, Sh. M. Rakhmonova, A. L. Borisova, O. N. Dzhioeva, O. M. Drapkina   +5 more
doaj   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Differential Expression of NLRP3 among Hematopoietic Cells

, 2011
Although the importance of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in health and disease is well appreciated, a precise characterization of NLRP3 expression is yet undetermined.
Kate Schroder, Manuel Zenger, Tschopp, Jurg, Guarda, Greta, Ferrero, I., Tardivel, Aubry, Chantal Mattmann, Zenger, M., Mattmann, Chantal, Mattmann, C., Schroder, Kate, Aubry Tardivel, Menu, P., Philippe Menu, Yazdi, A.S., Yazdi, Amir S., Zenger, Manuel, Tardivel, A., Tschopp, J., Isabel Ferrero, Schroder, K., Greta Guarda, Menu, Philippe, Ferrero, Isabel, Amir S. Yazdi, Guarda, G., Jürg Tschopp, Mattmann C, Guarda G, Schroder K, Menu P, Zenger M, Tardivel A, Ferrero I, Tschopp J, Yazdi AS   +35 more
core   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source