Results 111 to 120 of about 104,328 (314)

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source

FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation

Cell Reports
The NLRP3 inflammasome is dysregulated in autoinflammatory disorders caused by inherited mutations and contributes to the pathogenesis of several chronic inflammatory diseases. In this study, we discovered that disulfiram, a safe US Food and Drug Administration (FDA)-approved drug, specifically inhibits the NLRP3 inflammasome but not the NLRC4 or AIM2 ...
Jie Xu, Joseph M. Pickard, Gabriel Núñez   +2 more
openaire   +2 more sources

Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

, 2015
Ema Ozaki,1 Matthew Campbell,1 Sarah L Doyle2,3 1Department of Genetics, 2Department of Clinical Medicine, School of Medicine, Trinity College Dublin, 3National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin ...
Campbell M, Doyle SL, Ozaki E
core  

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Etude des différents signaux d'activation de l'inflammasome dans les monocytes/macrophages : implication dans la réponse inflammatoire vis-à-vis des nanotubes de carbone et de Leishmania infantum

, 2012
La vision de l'immunité en tant qu'entité discriminant les éléments du soi à protéger et du non soi à combattre a évolué ces dernières années avec la découverte des signaux de dangers endogènes et certains de leurs récepteurs associés.
Meunier, Etienne
core  

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Research progress on NLRP3 inflammasomes in male reproductive immunity

Exploration of Immunology
The male reproductive immune system plays a pivotal role in safeguarding sperm from immune attacks and preventing the incursion of foreign pathogens. Nucleotide-binding and oligomerization domain-like receptors (NOD-like receptors, NLRs) family protein ...
Xue Zhang, Xinyi Dong, Yafei Kang, Xiaohang Liu, Chengchang Zhang, Jiaxin Zhang, Shuting Chen, Donghui Huang   +7 more
doaj   +1 more source

Keys to NLRP3 inflammasome activation and the resulting pyroptosis from an evolutionary perspective

, 2020
The body has evolved maladaptive biochemical mechanisms to mitigate a predicted infection when it is under psychological stress. It also triggers depression or withdrawal behavior accompanied by biochemical inflammatory cascades.
Hijaz, Marwa
core  

Polychlorinated Biphenyl Quinone Induces Caspase 1‑Mediated Pyroptosis through Induction of Pro-inflammatory HMGB1-TLR4-NLRP3-GSDMD Signal Axis

, 2019
Polychlorinated biphenyls (PCBs) are one of the most refractory environmental pollutants. Because of their ubiquitous existence in the biological systems (including human body), it is important to investigate their toxic behavior.
Yawen Wang (1578763), Zixuan Liu (475331), Wenjing Dong, Qi Qin, Yang Song, Qiushuang Zhu, Bingwei Yang, Qi Qin (456777), Erqun Song (629771), Qiushuang Zhu (6620189), Xiaomin Xia (484046), Yawen Wang, Wenjing Dong (117921), Erqun Song, Xiaokang Zhu (4019003), Bingwei Yang (5657015), Xiaomin Xia, Zixuan Liu, Xiaokang Zhu, Yang Song (88132)   +19 more
core   +1 more source

NLRP3 controls ATM activation in response to DNA damage

, 2020
The DNA damage response (DDR) is essential to preserve genomic integrity and acts as a barrier to cancer. The ATM pathway orchestrates the cellular response to DNA double strand breaks (DSBs), and its attenuation is frequent during tumorigenesis.
Py, F. Bénédicte, Bodnar-Wachtel, Mélanie, Py, Bénédicte, Hall, Janet, Guey, Baptiste, Goutagny, Nadège, Bartosch, Birke, Couté, Yohann, Huber, Anne-Laure, Lantuejoul, Sylvie, Ballot, Elise, Gerossier, Laetitia, Hacot, Sabine, Gorry, Julie, Ballesta, Annabelle, Petrilli, Virginie, Ghiringhelli, François   +16 more
core   +1 more source