Results 121 to 130 of about 113,850 (298)

Electroacupuncture Inhibits NLRP3-Mediated Microglial Pyroptosis to Ameliorate Chronic Neuropathic Pain in Rats [PDF]

Wenyun Kui, Yanan Li, Zhen Gu, Lei Xie, Aiping Huang, Shuyi Kong, Lilong Song, Lingxing Li, Jun Yu, Chun-Chun Xue, Kaiqiang Wang Department of Pain, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese ...
Song L, Kui W, Xue CC, Li Y, Xie L, Gu Z, Kong S, Huang A, Yu J, Li L, Wang K   +10 more
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A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Avicularin Treatment Ameliorates Ischemic Stroke Damage by Regulating Microglia Polarization and its Exosomes via the NLRP3 Pathway

Journal of Integrative Neuroscience
Background: Avicularin (AL), an ingredient of Banxia, has anti-inflammatory properties in cerebral disease and regulates polarization of macrophages, but its effects on ischemic stroke (IS) damage have not been studied.
Yan Shi, Yufeng Yang, Juntong Liu, Jinling Zheng   +3 more
doaj   +1 more source

NLRP3 Inflammasome in Gynecologic Inflammatory Diseases: Mechanisms, Pathophysiology, and Therapeutic Strategies [PDF]

TianHui Wang,1 Rui Zheng,1 YangFan Qu,1 Ping Shu,1 WenXia Ai,1 Jiao Zhao,1 Li Liu1,2 1Department of Obstetrics and Gynecology, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2Department of Obstetrics and Gynecology ...
Ai W, Shu P, Liu L, Wang T, Zheng R, Qu Y, Zhao J   +6 more
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NLRP3-, ASC- and caspase-1-dependent secretion of IL-1β in mouse macrophages stimulated with unbaked calculus.

, 2016
Macrophages from wild-type (WT) (A, D, G, H), NLRP3-deficient (B, E), and ASC-deficient (C, F) mice were stimulated with indicated concentrations (A–C, H) or 500 μg/mL (D–G) of unbaked calculus for 8 h (A–C, G, H) or the indicated time (D–F).
Atsutoshi Yoshimura (3121836), Yukio Ozaki (503373), Takashi Kaneko (1281171), Toshihiro Miyazaki (154749), Jorge Luis Montenegro Raudales (3121833), Ziauddin SM (3121842), Takashi Ukai (3121839), Eicke Latz (416789), Yoshitaka Hara (63619)   +8 more
core   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024

Journal of Multidisciplinary Healthcare
YanJie Lian,1,2,* Heyi Zhang,1,2,* Wenlong Xing,1 Sinai Li,3 Xiaolei Lai,1 Sihan Jia,1 JuJu Shang,1 Hongxu Liu1 1Department of Cardiovascular, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s
Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H   +7 more
doaj  

NLRP3 inflammasome: A therapeutic option for kidney disease? [PDF]

, 2017
Objective To determine if considering inflammasome NLRP3 as a treatment option for kidney disease is possible.Methods Literature review related to NLRP3 inflammasome structure, biological function and relationship with renal disease and others ...
Suárez Useche, Raibel Janis, Buelvas Jiménez, Neudo, Vielma Guevara, José Ramón   +2 more
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Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

NLRP3 Inflammasome Upregulates PD-L1 in Ovarian Cancer and Contributes to an Immunosuppressive Microenvironment [PDF]

Wenjing Pan,1,* Zhaoyang Jia,1,* Jingtong Du,1,* Kexin Chang,2 Yiming Liu,2 Wei Liu,1 Xibo Zhao,3 Wenhua Tan1 1Department of Gynecology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150081, People’s ...
Pan W, Liu Y, Chang K, Tan W, Du J, Jia Z, Liu W, Zhao X   +7 more
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