Results 131 to 140 of about 104,328 (314)

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function

Xiehe Yixue Zazhi
Disseminated intravascular coagulation (DIC) triggered by sepsis is a major challenge in the emergency and critical care of severely ill patients. The inflammasome is an essential component of the human immune system, and its activation can mediate ...
GAO Jiawei, DENG Xinkai, HAN Xiaobo, LI Xiao, CHAI Yahao, ZHANG Lei   +5 more
doaj   +1 more source

Case Report: A heterozygous mutation of NLRP3 in a Chinese child with NLRP3-AID

Frontiers in Pediatrics
BackgroundNLR family pyrin domain containing 3 (NLRP3)–associated autoinflammatory disease (NLRP3-AID), formerly known as cryopyrin-associated periodic syndrome, is a group of AIDs comprising neonatal-onset multisystem inflammatory disorder, Muckle–Wells syndrome, and familial cold autoinflammatory syndrome.
Ruan, Yangming, Ge, Ting, Wang, Yizhong, Zhang, Ting, Song, Feifei   +4 more
openaire   +2 more sources

NLRP3-, ASC- and caspase-1-dependent secretion of IL-1β in mouse macrophages stimulated with unbaked calculus.

, 2016
Macrophages from wild-type (WT) (A, D, G, H), NLRP3-deficient (B, E), and ASC-deficient (C, F) mice were stimulated with indicated concentrations (A–C, H) or 500 μg/mL (D–G) of unbaked calculus for 8 h (A–C, G, H) or the indicated time (D–F).
Atsutoshi Yoshimura (3121836), Yukio Ozaki (503373), Takashi Kaneko (1281171), Toshihiro Miyazaki (154749), Jorge Luis Montenegro Raudales (3121833), Ziauddin SM (3121842), Takashi Ukai (3121839), Eicke Latz (416789), Yoshitaka Hara (63619)   +8 more
core   +1 more source

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, EarlyView.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source

Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway

Open Medicine
Appropriate formation of blood vessels is critical for tendon-bone healing during tendon injury, as excessive angiogenesis would exacerbate scar formation and lead to chronic pain and dysfunction.
Yang Yong, Wang Huajun, Hou Huige, Chen Jiwen, Chen Xiaolei, Zheng Hongjian, Zheng Kai, Ye Baofei, Wu Chunhui, Zheng Xiaofei, Yuan Shiguo, Zheng Boyuan   +11 more
doaj   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

miR-22 Suppresses Tumor Invasion and Metastasis in Colorectal Cancer by Targeting NLRP3

Cancer Management and Research, 2020
Jinchun Cong,1,* Jian Gong,2,* Chuanjia Yang,3 Zhixiu Xia,1 Hong Zhang1 1Department of Colorectal Tumor Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, People’s Republic of China; 2Department of Clinical Pharmacy, Shenyang
Cong J, Gong J, Yang C, Xia Z, Zhang H
doaj  

Scalp electroacupuncture targeting trigeminal nerve activation alleviates post‐traumatic stress disorder–induced depression and neuroinflammation in mice

Animal Models and Experimental Medicine, EarlyView.
Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee, Yoongeun Kim, Hyungjun Kim, Dae‐Hyun Hahm   +3 more
wiley   +1 more source

Avicularin Treatment Ameliorates Ischemic Stroke Damage by Regulating Microglia Polarization and its Exosomes via the NLRP3 Pathway

Journal of Integrative Neuroscience
Background: Avicularin (AL), an ingredient of Banxia, has anti-inflammatory properties in cerebral disease and regulates polarization of macrophages, but its effects on ischemic stroke (IS) damage have not been studied.
Yan Shi, Yufeng Yang, Juntong Liu, Jinling Zheng   +3 more
doaj   +1 more source