Results 131 to 140 of about 120,852 (299)

Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024

Journal of Multidisciplinary Healthcare
YanJie Lian,1,2,* Heyi Zhang,1,2,* Wenlong Xing,1 Sinai Li,3 Xiaolei Lai,1 Sihan Jia,1 JuJu Shang,1 Hongxu Liu1 1Department of Cardiovascular, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s
Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H   +7 more
doaj  

Implication of the LRR Domain in the Regulation and Activation of the NLRP3 Inflammasome

International audienceThe NLRP3 inflammasome is a critical component of the innate immune response. NLRP3 activation is a tightly controlled process involving an initial priming to express NLRP3, pro-IL-1 β, and pro-IL-18, followed by an activation ...
Georgin-Lavialle, Sophie, Cescato, Margaux, Rodero, Mathieu P, Bénédicte F Py, Yixiang Y J Zhu, Mathieu P Rodero, Py, Bénédicte, F, Laurent Le Corre, Le Corre, Laurent, Sophie Georgin-Lavialle, Zhu, Yixiang, y J, Margaux Cescato   +11 more
core   +1 more source

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

Electroacupuncture Inhibits NLRP3-Mediated Microglial Pyroptosis to Ameliorate Chronic Neuropathic Pain in Rats [PDF]

Wenyun Kui, Yanan Li, Zhen Gu, Lei Xie, Aiping Huang, Shuyi Kong, Lilong Song, Lingxing Li, Jun Yu, Chun-Chun Xue, Kaiqiang Wang Department of Pain, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese ...
Song L, Kui W, Xue CC, Li Y, Xie L, Gu Z, Kong S, Huang A, Yu J, Li L, Wang K   +10 more
core  

Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists

<p>Supplemental tables for "Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists", Hollingsworth, Veeraraghavan, Paulo, Harper 2024. <a href="https://harperlab.pubpub.org/pub/nlrp3" target="_blank" rel="noopener">https://
Hollingsworth, L. Robert
core   +2 more sources

Inhibition of Hyperhomocysteinemia-Induced Inflammasome Activation and Glomerular Sclerosis by NLRP3 Gene Deletion

, 2014
Background/Aims: Hyperhomocysteinemia (hHcys) has been reported to initiate Nod-like receptor protein 3 (NLRP3) inflammasome formation and activation in podocytes, leading to glomerular dysfunction and sclerosis. However, it remains unknown whether Nlrp3
Pin-Lan Li, Guangbi Li, Min Xia, Sabena M. Conley, Krishna M. Boini   +4 more
core   +1 more source

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

NLRP3 activating mutation does not increase islet glucose toxicity.

, 2014
(A) DNA was isolated from 300–500 islets of the indicated genotypes and PCR was performed using appropriate primers. Islets isolated from wild-type (+/+ NLRP3+/+) mice were used for lanes 1, 2, 4, 6 and 8, while lanes 3, 5 and 7 show genotyping results ...
Lorraine Elkerbout (663189), Jibran A. Wali (322048), Esteban N. Gurzov (185104), Helen E. Thomas (316652), Seth L. Masters (371900), Stacey Fynch (663188), Thomas W. Kay (316650)   +6 more
core   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis

, 2019
Baoqing Liu,1 Xiaoxiang Mao,2,3 Dandan Huang,2,3 Fei Li,1 Nianguo Dong11Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of ...
Huang D, Li F, Mao X, Liu B, Dong N
core