Results 71 to 80 of about 113,850 (298)

Protective effects of CY-09 and astaxanthin on NaIO3-induced photoreceptor inflammation via the NLRP3/autophagy pathway [PDF]

International Journal of Ophthalmology
AIM: To study the effect of the NLRP3/autophagy pathway on the photoreceptor inflammatory response and the protective mechanism of CY-09 and astaxanthin (AST).
Xiao-Li Wang, Yun-Xia Gao, Qiong-Zhen Yuan, Ming Zhang   +3 more
doaj   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

Assessment of the inflammatory response in convalescents of a new coronavirus infection in the catamnesis

Acta Biomedica Scientifica
Background. The  pathogenetic mechanism of  the  development of  a  prolonged systemic inflammatory process in patients who have suffered a new coronavirus infection remains an  urgent problem.
T. G. Lobova, T. I. Vitkina
doaj   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

Pharmacological Modulation of NLRP3: From Therapy Personalization to Innovative Drugs

Frontiers in Bioscience-Landmark
The nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) inflammasome is a multiprotein complex fundamental for the secretion of pro-inflammatory cytokines during the innate immune response.
Giulia Zudeh, Sara Sossai, Jacopo Angelini, Gabriele Stocco, Marianna Lucafò   +4 more
doaj   +1 more source

A purineg receptorok szerepe az NLRP3 inflammoszóma működésben

, 2013
A fertőzések leküzdésére két fő védekezési forma a veleszületett (natív) és a szerzett (adaptív) immunrendszer alakult ki. A kétféle immunrendszer szorosan összekapcsolódik. A humorális és sejtes elemek különbséget tudnak tenni saját és nem saját (káros)
Yahya, Kamel
core  

Reviewing the importance of TLR-NLRP3-pyroptosis pathway and mechanism of experimental NLRP3 inflammasome inhibitors

, 2021
Cells encounter continuous challenges due to tissue insult caused by endogenous and/or exogenous stimuli. Among the mechanisms set in place to counterbalance the tissue insult, innate immunity is always at the forefront.
Nampoothiri, M, Kinra, M, Mudgal, J, Arora, D   +3 more
core   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Empagliflozin Inhibits OSCC Proliferation and Migration by Suppressing SLC2A3 and NLRP3

Namık Kemal Tıp Dergisi
Aim: High glucose and inflammation facilitate oral squamous cell carcinoma (OSCC) progression. The glucose transporter solute carrier family 2 member 3 (SLC2A3) and the nucleotide-binding oligomerization domain, leucine-rich repeat-containing family ...
Gülçin TEZCAN
doaj   +1 more source

L’inflammasome NLRP3 dans la physiopathologie des infections virales

, 2022
L’inflammasome NLRP3 est un complexe multiprotéique intracellulaire impliqué dans la réponse immunitaire innée. Après la détection de signaux de dangers, tels que ceux provenant d’agents pathogènes, ce complexe s’assemble afin d’initier la production et ...
Eva Mellan, Py, Bénédicte, Marlène Chemarin, Laurent Boyer, Fabienne Venet, Chemarin, Marlène, Venet, Fabienne, Anastassia Mazet, Bénédicte F. Py, Coudereau, Rémy, Océane Dufies, Rémy Coudereau, Dufies, Océane, Mellan, Eva, Mazet, Anastassia, Boyer, Laurent   +15 more
core   +1 more source