Results 111 to 120 of about 115,042 (335)

Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke

Frontiers in Cellular Neuroscience, 2020
Stroke is one of the major devastating diseases with no effective medical therapeutics. Because of the high rate of disability and mortality among stroke patients, new treatments are urgently required to decrease brain damage following a stroke.
Ya-Shuo Feng, Zi-Xuan Tan, Man-Man Wang, Ying Xing, Fang Dong, Feng Zhang, Feng Zhang   +6 more
doaj   +1 more source

SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release [PDF]

, 2021
Caroline Junqueira, Ângela C. Crespo, Shahin Ranjbar, Mercedes Lewandrowski, Jacob Ingber, Luna de Lacerda, Blair A. Parry, Sagi Ravid, Sarah A. Clark, Felicia Ho, Setu M. Vora, Valerie Leger, Caroline Beakes, Justin Margolin, Nicole Russell, Kyle R. Kays, Lee Gehrke, Upasana Das Adhikari, Lauren A. Henderson, Erin Janssen, Douglas S. Kwon, Chris Sander, Jonathan Abraham, Michael R. Filbin, Marcia B. Goldberg, Hao Wu, Gautam Mehta, Steven Bell, Anne E. Goldfeld, Judy Lieberman   +29 more
openalex   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation [PDF]

, 2020
Yang Zhou, Zhizi Tong, Songhong Jiang, Wenyan Zheng, Jianjun Zhao, Xiangmei Zhou   +5 more
openalex   +1 more source

NLRP2 controls age-associated maternal fertility [PDF]

, 2016
Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are well-known for their key roles in the immune system. Ectopically expressed NLRP2 in immortalized cell lines assembles an inflammasome and inhibits activation of the proinflammatory ...
Agostini, Anna A. Kuchmiy, Barton, Bruey, Court, Fontalba, Geddes, Jinke D’Hont, Kanneganti, Kinoshita, Kuida, Lamkanfi, Lamkanfi, Lupfer, Ma, Meyer, Mohamed Lamkanfi, Nguyen, Peng, Peng, Ting, Tino Hochepied, Tong, Van Gorp, Vande Walle   +24 more
core   +2 more sources

Fatty acid synthesis and NLRP3-inflammasome

Oncotarget, 2015
Fatty acid synthesis is an important process of the lipogenesis [1]. Fatty acid synthesis is tightly regulated by key enzymes including fatty acid synthase (FASN) [1]. FASN and lipogenesis related enzymes are upregulated in various cancer cells and associated with oncogenic progression [1].
Jong-Seok, Moon, Kiichi, Nakahira, Augustine M K, Choi   +2 more
openaire   +2 more sources

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

Advanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My‐Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet   +15 more
wiley   +1 more source

RETRACTED: Naringenin facilitates M2 macrophage polarization after myocardial ischemia–reperfusion by promoting nuclear translocation of transcription factor EB and inhibiting the NLRP3 inflammasome pathway [PDF]

, 2023
Kuiying Ma, Wenqing Liu, Qi Liu, Pengfei Hu, Lingyu Bai, Miao Yu, Yan Yang   +6 more
openalex   +1 more source

Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides [PDF]

, 2016
Inflammasomes are molecular complexes activated by infection and cellular stress, leading to caspase-1 activation and subsequent interleukin-1β (IL-1β) processing and cell death.
Cridland, Simon O., Sester, David P., Stacey, Katryn J., Thygesen, Sara J., Wilton, Steve D.   +4 more
core   +1 more source