Results 111 to 120 of about 28,373 (282)

SMG6’s PIN (PilT N-Terminus) Domain Is Required for Nonsense-Mediated mRNA Decay (NMD) In Vivo

Cells
Nonsense-mediated mRNA decay (NMD) is a highly conserved RNA quality and quantity surveillance machinery in eukaryotic cells, serving as an important node in the post-transcriptional gene expression.
Baihui Chai, Xiao Tan, Yan Li, Chengyan Chen, Xin Ma, Tangliang Li   +5 more
doaj   +1 more source

In‐frame variants in TP53 gene identified in adult leukemia samples are predominantly deleterious: a study of the TP53 Network of Education and Research Initiative on CLL

The Journal of Pathology, EarlyView.
Abstract The prognostic and predictive impact of TP53 variants in leukemia led to their inclusion in diagnostic and treatment guidelines, increasing the demand for rapid, reliable laboratory analysis, interpretation, and reporting. While most TP53 variants identified in tumor samples can be interpreted using data from large‐scale functional studies ...
Šárka Pavlová, Johana Gombíková, Silvia Petrezsélyová, Libor Macůrek, Marcela Ženatová, Marie Zádrapová, Anna Panovská, Eva Zapletalová, Blanca Ferrer Lores, Alicia Serrano Alcalá, Eugen Tausch, Stephan Stilgenbauer, Fanny Baran‐Marszak, Gregory Lazarian, Miguel Alcoceba, Ana Balanzategui, Lisa Bonello, Ivana Ježíšková, Martina Sopkovičová, Silvia Zibellini, Marzia Varettoni, Audrey Bidet, Helena Podgornik, Sandra Šućurović, Riccardo Moia, Mónica López‐Guerra, Mark Catherwood, Šárka Pospíšilová, Jitka Malčíková   +28 more
wiley   +1 more source

Nonsense-mediated mRNA decay (NMD) restricts replication of mammalian RNA viruses

, 2014
A genome-wide siRNA screen against host factors that affect the infection of Semliki Forest virus (SFV), a positive-strand (+)RNA virus, revealed that components of the nonsense-mediated mRNA decay (NMD) pathway restrict early, post-entry steps of the ...
Mühlemann, Oliver
core  

Rethinking intensification: Biodiversity‐inclusive management sustains coconut yields

PLANTS, PEOPLE, PLANET, EarlyView.
Coconut palm expansion in West Africa will shape rural livelihoods and ecosystems. Our findings show that intensive practices reduce beneficial soil fungi and increase pathogens, threatening long‐term productivity. Lower‐intensity management that retains ground vegetation can sustain or boost yields while improving soil health.
Benjamin J. Roberts, C. M. ( Tilly) Collins, Konan Engueran Djaha, Hamish Duncalf‐Youngson, Konan Jean Louis, Hala N'klo, Emma Ransome, Doubi Bi Tra Serges, Jahcub Trew, Jake Williams, Vincent Savolainen   +10 more
wiley   +1 more source

NMD burden as orthogonal predictors of cytolytic activity.

, 2019
(A) Schematic of data processing pipeline for deriving NMD burden, incorporating TCGA datasets for CNA, exome-seq, and mRNA-seq. (B) Pan-cancer correlation among features for mutations and NMD burden.
Boyang Zhao (2197552), Justin R. Pritchard (7553483)   +1 more
core   +1 more source

Management and incipient domestication of Chamaedorea tepejilote in agroforestry systems in Mexico

PLANTS, PEOPLE, PLANET, EarlyView.
Native wild plants are key elements in addressing global biodiversity loss and supporting sustainable food systems. We investigated how rural communities in Mexico manage Chamaedorea tepejilote, a wild palm with edible male inflorescences, by combining ethnobotanical, genetic, morphological and ecological approaches.
Viviana Andrade, Alejandro Casas, Edna Arévalo‐Marín, Gonzalo D. Álvarez‐Ríos, Hernán Alvarado‐Sizzo, Vanessa Guerrero‐Hernández, Paola Ubiergo‐Corvalán, Maite Lascurain‐Rangel   +7 more
wiley   +1 more source

Nonsense-mediated mRNA decay: a key regulatory system engaged in cancer

Cell Communication and Signaling
Nonsense-mediated mRNA decay (NMD) is a critical cellular surveillance mechanism that prevents the translation of defective or deleterious proteins. The regulation of NMD, including both its activation and the evasion of its target mRNA, is intricately ...
Hongyu Pan, Xinyu Wu, Bingshuang Hu, Huihua Xiong, Yao Luo, Jian-Kang Zhou   +5 more
doaj   +1 more source

Ribosome profiling in mammalian cells to reveal the role of NMD factors in translation termination

, 2016
Eukaryotes have acquired numerous ways to control the integrity and quality of mRNA. Nonsense-mediated mRNA decay (NMD) is one of these conserved pathways that contribute to mRNA surveillance.
Annibaldis, Giuditta
core  

Early diagnosis of Duchenne muscular dystrophy - a Treat-NMD international workshop

The diagnosis of Duchenne muscular dystrophy (DMD) is significant at any stage, however an early diagnosis in a presymptomatic or very early phase of DMD, offers unique opportunities and challenges for families and health care providers. Currently, there
Jones, Kj, Parsons, Ja, Servais, L, Lorentzos, M   +3 more
core   +1 more source

Planting for healthy air: Urban biodiversity enhances natural chemical environments

PLANTS, PEOPLE, PLANET, EarlyView.
Cities urgently need nature to improve public health, support biodiversity, and increase resilience to climate change. Yet not all green spaces offer the same benefits. In this study, we show that more diverse urban plantings create richer “chemical environments”; subtle, naturally scented atmospheres formed by plant emissions that can influence how ...
Aurora Ruggeri, Fethi Ben Fraj, Gaetan Glauser, Gregory Röder, Ola Söderström, Sergio Rasmann   +5 more
wiley   +1 more source