Results 91 to 100 of about 240,251 (364)

Distribution of Extrasynaptic NMDA Receptors on Neurons

The Scientific World Journal, 2012
NMDA receptors are found in both synaptic and extrasynaptic locations on neurons. NMDA receptors also can be found on neurons in early stages prior to synaptogenesis, where they may be involved in migration and differentiation.
Ronald S. Petralia
doaj   +1 more source

Computational study of NMDA conductance and cortical oscillations in schizophrenia

Frontiers in Computational Neuroscience, 2014
N-methyl-D-aspartate (NMDA) receptor hypofunction has been implicated in the pathophysiology of schizophrenia. The illness is also characterized by gamma oscillatory disturbances, which can be evaluated with precise frequency specificity employing ...
Kubra eKomek Kirli, Raymond Young-Jin Cho, Raymond Young-Jin Cho, G B Ermentrout   +3 more
doaj   +1 more source

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko, Kambe, Yuki, Taniura, Hideo, Yoneda, Yukio   +3 more
core  

Biomimetic Thalidomide Nanoparticles: Targeted and Sustained Therapeutic Strategy for Oxygen‐Induced Retinopathy

Aggregate, EarlyView.
Magnesium acetyl taurate and thalidomide co‐assembled nanoparticles (MT NPs) are prepared via Super‐stable Pure Nanomedicine Formulation Technology (SPFT), and the NPs are further coated with transferrin‐modified cell membrane vesicles to construct Tfm@MT nanomedicine for oxygen‐induced retinopathy treatment.
Mengdie Li, Shundong Cai, Jinfa Ye, Lang Ke, Guanxiong Yang, Shaopan Wang, Cuiting Chen, Peixin Cai, Hui Liu, Xingyuan Wei, Songyi Wang, Yun Han, Shilong Shao, Min Su, Gang Liu, Chengchao Chu   +15 more
wiley   +1 more source

Generalization of NMDA-Receptor Antagonists to the Discriminative Stimulus Effects of κ-Opioid Receptor Agonists U-50,488H, but Not TRK-820 in Rats

Journal of Pharmacological Sciences, 2006
.: Generalizations of NMDA-receptor antagonists to the discriminative stimulus effects of κ-opioid receptor agonists in rats were examined. Phencyclidine, MK-801, and ketamine, noncompetitive NMDA-receptor antagonists, generalized to the discriminative ...
Tomohisa Mori, Mutsuko Nomura, Kazumi Yoshizawa, Hiroshi Nagase, Toshiko Sawaguchi, Minoru Narita, Tsutomu Suzuki   +6 more
doaj   +1 more source

In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]

, 2008
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien, Mary Heng, Peter Detloff, Phillip Wang, Roger Albin   +4 more
core   +1 more source

Nitric oxide and synaptic function [PDF]

, 1994
The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype

BMC Neuroscience, 2010
Background Autophagy, an intracellular response to stress, is characterized by double membrane cytosolic vesicles called autophagosomes. Prolonged autophagy is known to result in autophagic (Type II) cell death.
Kobeissy Firas H, Zheng Wenrong, Larner Stephen F, Liu Ming C, Zhang Zhiqun, Sadasivan Shankar, Hayes Ronald L, Wang Kevin KW   +7 more
doaj   +1 more source

Clinical and Molecular Genetic Characterization of Landau Kleffner Syndrome: An Observational Cohort and Experimental Study

Annals of Neurology, EarlyView.
Objective Landau–Kleffner syndrome (LKS), is a rare, poorly‐understood epileptic encephalopathy with spike–wave activation in sleep associated with mutations in GRIN2A, encoding the N‐Methyl‐D‐Aspartate receptor (NMDAR) GluN2A subunit. Physicians rely on empirical treatments, with scarce information on treatment efficacy and outcomes.
Adeline Ngoh, Maria Clark, Rebecca Greenaway, Xiumin Chen, Kimberley M. Reid, Katy Barwick, Esther Meyer, Dale Moulding, Natalie Trump, J. Helen Cross, Sean D. Fraser, Lachlan de Hayr, Dimitri M. Kullmann, Joseph W. Lynch, Robert J. Harvey, Manju A. Kurian   +15 more
wiley   +1 more source