Results 111 to 120 of about 110,732 (265)

Potentiation effects of the positive allosteric modulator PTC‐174 on NMDA receptors in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators bind to secondary binding sites on the receptor and alter receptor conformation and activation, changing agonist potency and efficacy. PTC‐174 is a novel NMDA receptor positive allosteric modulator that particularly enhances activity of receptors containing GluN2C or GluN2D subunits.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source

Characterization of a monkey model with experimental retinal damage induced by N-methyl-D-aspartate

Disease Models & Mechanisms
Guo Liu, Longxiang Huang, Junkai Tan, Yun Wang, Chunlin Lan, Yaxi Chen, Yukai Mao, Xizhen Wang, Ning Fan, Yihua Zhu, Xianjun Zhu, Xuyang Liu   +11 more
doaj   +1 more source

NMDA receptor kinetics drive distinct routes to chaotic firing in pyramidal neurons. [PDF]

Front Comput Neurosci
Borjkhani M, Borjkhani H, Sharif MA, Bahrami F, Janahmadi M.   +4 more
europepmc   +1 more source

Genetic testing in paediatric neurological disorders

Developmental Medicine &Child Neurology, EarlyView.
In this study 390 paediatric patients with neurological disorders underwent genetic testing via exome sequencing, commercial panel, in‐house epilepsy, and movement disorder gene panels. Exome sequencing provides the highest diagnostic yield, and severe developmental delay and hypotonia predicted pathogenic variants in the exome sequencing cohort ...
Wafa Bani Uraba, Byoung Chan Lee, Shekeeb S. Mohammad, Katrina Fisk, Michael Buckley, Russell C. Dale, Tony Roscioli, Paediatric Neurogenomic Working Group, Manoj P. Menezes, Sachin Gupta, Christopher Troedson, Esther Tantsis, Richard Webster, Bruce Bennetts, Deepak Gill, Kavitha Kothur   +15 more
wiley   +1 more source

Magnesium neuroprotection in retinal ganglion cells: A computational study of frequency-dependent therapeutic windows and intervention timing. [PDF]

PLoS One
Borjkhani M, Borjkhani H, Sharif MA.
europepmc   +1 more source

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

Regulation of NMDA receptor interactions with the actin cytoskeleton in dendritic spine development. [PDF]

Front Cell Neurosci
Lloyd J, Litwa K.
europepmc   +1 more source

Transcranial electric stimulation in chronic pain: Effects on quality of life, physical function, activity and clinical status

Journal of Neuropsychology, EarlyView.
Abstract Transcranial electric stimulation represents a promising non‐invasive neuromodulatory technique targeting maladaptive nociplastic changes in chronic pain (CP) with analgesic effects. However, its impact beyond pain reduction on broader outcomes such as quality of life (QoL) and physical function remains unclear.
Antonio Gil‐Ugidos, María López‐Corchón, Gavriella Τsiarleston, Víctor Segura‐Jiménez, María Teresa Carrillo‐de‐la‐Peña   +4 more
wiley   +1 more source

Ketamine Dosing Across Clinical Indications: A Narrative Review Organized by Proposed NMDA-Related Mechanisms. [PDF]

J Clin Pharmacol
Glue P, Beaglehole B.
europepmc   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source