Results 101 to 110 of about 217,671 (368)

NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies

Brain, 2023
Abstract N-methyl-D-aspartate receptor (NMDAR) encephalitis is the most common subtype of autoimmune encephalitis characterized by a complex neuropsychiatric syndrome usually including memory impairment. Patients develop an intrathecal immune response against NMDARs with antibodies that presumably bind to the amino-terminal domain of the
Stephan Steinke, Toni Kirmann, Eleonora A Loi, Jana Nerlich, Iron Weichard, Philipp Kuhn, Torsten Bullmann, Andreas Ritzau-Jost, Filiz Sila Rizalar, Harald Prüss, Volker Haucke, Christian Geis, Michael Hust, Stefan Hallermann   +13 more
openaire   +3 more sources

N-Methyl-D-aspartic Acid (NMDA) in the nervous system of the amphioxus Branchiostoma lanceolatum

BMC Neuroscience, 2007
Background NMDA (N-methyl-D-aspartic acid) is a widely known agonist for a class of glutamate receptors, the NMDA type. Synthetic NMDA elicits very strong activity for the induction of hypothalamic factors and hypophyseal hormones in mammals.
Garcia-Fernàndez Jordi, Ferrandino Gabriele, Topo Enza, Fisher George H, D'Aniello Salvatore, D'Aniello Antimo   +5 more
doaj   +1 more source

Advances and Barriers in Understanding Presynaptic N-Methyl-D-Aspartate Receptors in Spinal Pain Processing

Frontiers in Molecular Neuroscience, 2022
For decades, N-methyl-D-aspartate (NMDA) receptors have been known to play a critical role in the modulation of both acute and chronic pain. Of particular interest are NMDA receptors expressed in the superficial dorsal horn (SDH) of the spinal cord ...
Annemarie Dedek, Annemarie Dedek, Michael E. Hildebrand, Michael E. Hildebrand   +3 more
doaj   +1 more source

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]

, 2012
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Bechmann, Ingo Jürgen, Dehghani, Faramarz, Ehrlich, Angela, Geisslinger, Gerd, Hobusch, Constance, Kallendrusch, Sonja, Koch, Marco, Nowicki, Marcin, Ziebell, Simone   +8 more
core   +3 more sources

Computational study of NMDA conductance and cortical oscillations in schizophrenia

Frontiers in Computational Neuroscience, 2014
N-methyl-D-aspartate (NMDA) receptor hypofunction has been implicated in the pathophysiology of schizophrenia. The illness is also characterized by gamma oscillatory disturbances, which can be evaluated with precise frequency specificity employing ...
Kubra eKomek Kirli, Raymond Young-Jin Cho, Raymond Young-Jin Cho, G B Ermentrout   +3 more
doaj   +1 more source

Dose-dependent effects of NMDA on retinal and optic nerve morphology in rats [PDF]

International Journal of Ophthalmology, 2019
AIM: To investigate dose-dependent effects of N-methyl-D-aspartate (NMDA) on retinal and optic nerve morphology in rats. METHODS: Sprague Dawley rats, 180-250 g in weight were divided into four groups.
Lidawani Lambuk, Azliana Jusnida Ahmad Jafri, Igor Iezhitsa, Renu Agarwal, Nor Salmah Bakar, Puneet Agarwal, Aimy Abdullah, Nafeeza Mohd Ismail   +7 more
doaj   +1 more source

How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models [PDF]

, 2011
It has been shown that plasticity is not a fixed property but, in fact, changes depending on the location of the synapse on the neuron and/or changes of biophysical parameters.
Aihara, Akbarian, Andreasen, Angulo, Beasley, Bernd Porr, Bi, Bower, Christoph Kolodziejski, Clopath, De Schutter, De Schutter, Egerton, Feinberg, Florentin Wörgötter, Freund, Guidotti, Hebb, Iglesias, Jolivet, Kehrer, Klopf, Koch, Lewis, Lindskog, Lisman, Lynsey McCabe, Magee, Markram, Morris, O’Mann, Paolo di Prodi, Paz, Pierri, Porr, Porr, Ragland, Rapoport, Rubin, Saudargiene, Shinoda, Somogyi, Straub, Tamosiunaite, Tamosiunaite, Tamosiunaite, Traub, Ulrich, Voegtlin, Yang, Zaitsev   +50 more
core   +1 more source

Distribution of Extrasynaptic NMDA Receptors on Neurons

The Scientific World Journal, 2012
NMDA receptors are found in both synaptic and extrasynaptic locations on neurons. NMDA receptors also can be found on neurons in early stages prior to synaptogenesis, where they may be involved in migration and differentiation.
Ronald S. Petralia
doaj   +1 more source

The Case of a 67‐Year‐Old Man With Memory Difficulties and Altered Sleep

Annals of Clinical and Translational Neurology, EarlyView.
Wesley Peng, Borna Bonakdarpour
wiley   +1 more source

Targeting the interaction of GABAB receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
There is no pharmacological treatment available to limit progressing neuronal death after cerebral ischemia. Here we show that targeting the interaction of GABAB receptors with CaMKII using a synthetic interfering peptide after an excitotoxic insult in cultured neurons or in brain slices from MCAO‐treated mice restored downregulated GABAB receptor ...
Karthik Balakrishnan, Mohammad Hleihil, Musadiq A. Bhat, Robert P. Ganley, Markus Vaas, Jan Klohs, Hanns Ulrich Zeilhofer, Dietmar Benke   +7 more
wiley   +1 more source