Results 111 to 120 of about 217,671 (368)

Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]

, 2009
The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core   +1 more source

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

Chemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb, Morkoss Fakhry, Ali K. Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +5 more
wiley   +1 more source

Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
Differential alteration of synaptic versus extrasynaptic NMDARs in P301S mice. Reduced density of synaptic NMDARs in excitatory synapses in the hippocampus of P301S mice at 10 months. NMDARs at excitatory synapses established on pyramidal cell spines and interneurons are significantly reduced in the CA1 region of the hippocampus compared to age‐matched
Rocío Alfaro‐Ruiz, Carolina Aguado, Alejandro Martín‐Belmonte, Ana Esther Moreno‐Martínez, Jesús Merchán‐Rubira, Félix Hernández, Jesús Ávila, Yugo Fukazawa, Rafael Luján   +8 more
wiley   +1 more source

nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge. [PDF]

, 2013
Huntington's disease (HD) is a neurodegenerative condition characterized by severe neuronal loss in the cortex and striatum that leads to motor and behavioral deficits.
Canzoniero, Lorella MT, Choi, Dennis W, Dugan, Laura L, Granzotto, Alberto, Sensi, Stefano L, Turetsky, Dorothy M   +5 more
core   +2 more sources

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype

BMC Neuroscience, 2010
Background Autophagy, an intracellular response to stress, is characterized by double membrane cytosolic vesicles called autophagosomes. Prolonged autophagy is known to result in autophagic (Type II) cell death.
Kobeissy Firas H, Zheng Wenrong, Larner Stephen F, Liu Ming C, Zhang Zhiqun, Sadasivan Shankar, Hayes Ronald L, Wang Kevin KW   +7 more
doaj   +1 more source

Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases

ChemBioChem, EarlyView.
This review explores current methods for detecting and characterising small tau aggregates, which are increasingly recognised as key drivers of neurotoxicity in tauopathies. It discusses emerging techniques such as single‐molecule pull‐down (SiMPull), single‐molecule Förster resonance energy transfer (smFRET), and cryo‐electron tomography (cryo‐ET ...
Dorothea Böken, Yunzhao Wu, Ziwei Zhang, David Klenerman   +3 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

Dual regulation by ethanol of the inhibitory effects of ketamine on spinal NMDA-induced pressor responses in rats

Journal of Biomedical Science, 2012
Background Acute exposure of ethanol (alcohol) inhibits NMDA receptor function. Our previous study showed that acute ethanol inhibited the pressor responses induced by NMDA applied intrathecally; however, prolonged ethanol exposure may increase the ...
Keng Nien-Tzu, Lin Hsun-Hsun, Lin Huei-Ru, Hsieh Wei-Kung, Lai Chih-Chia   +4 more
doaj   +1 more source

Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment

Cell Biology International, EarlyView.
ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty, Natasha Gupta, Debanjan Bhattacharya   +2 more
wiley   +1 more source

AMPA, NMDA and GABAA receptor mediated network burst dynamics in cortical cultures in vitro [PDF]

Proc. Int. Works. Comp. Syst. Biol. TICSP series 8 (2011) 181-184, 2018
In this work we study the excitatory AMPA, and NMDA, and inhibitory GABAA receptor mediated dynamical changes in neuronal networks of neonatal rat cortex in vitro. Extracellular network-wide activity was recorded with 59 planar electrodes simultaneously under different pharmacological conditions.
arxiv