Results 121 to 130 of about 217,671 (368)

PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology [PDF]

, 2018
The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling.
Azmoon, Pardis, Banki, Michael A, Campana, Wendy M, Gilder, Andrew S, Gonias, Steven L, Mantuano, Elisabetta   +5 more
core   +2 more sources

Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-D-aspartate currents by dopamine D1 receptor activation in striatum

Frontiers in Systems Neuroscience, 2011
Dopamine, via activation of D1 receptors, enhances N-methyl-D-aspartate (NMDA) receptor-mediated responses in striatal medium-sized spiny neurons. However, the role of specific NMDA receptor subunits in this enhancement remains unknown.
Emily L Jocoy, Véronique M André, Damian M Cummings, Shilpa P Rao, Nanping eWu, Amy J Ramsey, Marc G Caron, Carlos eCepeda, Michael S Levine   +8 more
doaj   +1 more source

A Proteomics Profiling Reveals the Neuroprotective Effects of Melatonin on Exogenous β‐amyloid‐42 Induced Mitochondrial Impairment, Intracellular β‐amyloid Accumulation and Tau Hyperphosphorylation in Human SH‐SY5Y Cells

Cell Biology International, EarlyView.
ABSTRACT Alzheimer's disease (AD) is prevalent in the elderly population and characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), composed of tau proteins, and extracellular deposition of beta‐amyloid protein (Aβ). The present study aimed to investigate the neuroprotective effects of melatonin on Aβ42‐induced AD‐like ...
Jiraporn Panmanee, Matthew Phanchana, Phorutai Pearngam, Nopphon Petchyam, Kornkanok Promthep, Ponlawit Wisomka, Suchanoot Kutpruek, Supitcha Pannengpetch, Tanya Prasertporn, Sujira Mukda, Piyarat Govitrapong, Chutikorn Nopparat   +11 more
wiley   +1 more source

No association between Parkinson disease and autoantibodies against NMDA-type glutamate receptors

Translational Neurodegeneration, 2019
Background IgG-class autoantibodies to N-Methyl-D-Aspartate (NMDA)-type glutamate receptors define a novel entity of autoimmune encephalitis. Studies examining the prevalence of NMDA IgA/IgM antibodies in patients with Parkinson disease with/without ...
Franziska Hopfner, Stefanie H. Müller, Dagmar Steppat, Joanna Miller, Nele Schmidt, Klaus-Peter Wandinger, Frank Leypoldt, Daniela Berg, Andre Franke, Wolfgang Lieb, Lukas Tittmann, Monika Balzer-Geldsetzer, Simon Baudrexel, Richard Dodel, Ruediger Hilker-Roggendorf, Elke Kalbe, Jan Kassubek, Thomas Klockgether, Inga Liepelt-Scarfone, Brit Mollenhauer, Petra Neuser, Kathrin Reetz, Oliver Riedel, Claudia Schulte, Jörg B. Schulz, Annika Spottke, Alexander Storch, Claudia Trenkwalder, Hans-Ulrich Wittchen, Karsten Witt, Ullrich Wüllner, Günther Deuschl, Gregor Kuhlenbäumer   +32 more
doaj   +1 more source

Translational Medicine in Alzheimer's Disease: The Journey of Donanemab From Discovery to Clinical Application

Chronic Diseases and Translational Medicine, EarlyView.
Donanemab, approved by the U.S. FDA in July 2024, targets amyloid plaques in the brain to treat Alzheimer's disease in patients with mild cognitive impairment or mild dementia. ABSTRACT Substantial research has been conducted to identify an efficient treatment for Alzheimer's disease (AD).
Nandhini Jayaprakash, Karthikeyan Elumalai   +1 more
wiley   +1 more source

How do neurons operate on sparse distributed representations? A mathematical theory of sparsity, neurons and active dendrites [PDF]

arXiv, 2016
We propose a formal mathematical model for sparse representations and active dendrites in neocortex. Our model is inspired by recent experimental findings on active dendritic processing and NMDA spikes in pyramidal neurons. These experimental and modeling studies suggest that the basic unit of pattern memory in the neocortex is instantiated by small ...
arxiv  

A Mathematical model for Astrocytes mediated LTP at Single Hippocampal Synapses [PDF]

, 2011
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP).
arxiv   +1 more source

Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets [PDF]

, 1998
Background and Purpose-Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is a neuronally mediated multistep process that is sensitive to cerebral hypoxia and ischemia (H/I).
Bari, Ferenc, Domoki, Ferenc, Veltkamp, R.   +2 more
core  

Consumption of Ginkgo biloba Extract and Swimming Training on NMDA and BDNF Plasma in Untrained Girls

Journal of Medicinal Plants, 2015
Background: Ginko biloba stimulate blood circulation to the brain. As a result of insufficiency to improve blood flow to the brain. Objective: The aim of this study was to investigate the effect of eight weeks endurance training swimming on BDNF and NMDA
B Hajirezaii, A Barari, A Abbassi Daloii
doaj  

Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels [PDF]

, 2006
It is known that glutamatergic and cholinergic systems interact functionally at the level of the cholinergic basal forebrain. The N-methyl-D-aspartate receptor (NMDA-R) is a multiprotein complex composed of NR1, NR2 and/or NR3 subunits.
Broide R.S., Damsma G., Dere E., Dingledine R., Finlay J.M., Gothert M., Kadotani H., Miyamoto Y., Potter P.E., Sabatino M., Schlett K., Sethy V.M.   +11 more
core   +2 more sources