Results 131 to 140 of about 240,251 (364)

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Activation inhibitors of nuclear factor kappa B protect neurons against the NMDA-induced damage in the rat retina

Journal of Pharmacological Sciences, 2017
We reported that high-mobility group Box-1 (HMGB1) was involved in excitoneurotoxicity in the retina. HMGB1 is known to activate nuclear factor kappa B (NF-κB). However, the role of NF-κB in excitotoxicity is still controversial.
Kenji Sakamoto, Tatsuya Okuwaki, Hiroko Ushikubo, Asami Mori, Tsutomu Nakahara, Kunio Ishii   +5 more
doaj   +1 more source

A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists [PDF]

, 1988
David Lodge, S.N. Davies, Martyn G. Jones, John D. Millar, David T. Manallack, Paul L. Ornstein, Anthony J.M. Verberne, N. Young, Philip M. Beart   +8 more
openalex   +1 more source

FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]

, 2014
The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca, Liu, Xiaoqian, Lobner, Doug   +2 more
core   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Near death experience and the NMDA receptor. [PDF]

, 1989
Karl Jansen
openalex   +1 more source

Seizures beget more than seizures: Understanding the cellular, structural, individual and societal impact of seizures in epilepsy

Epilepsia Open, EarlyView.
Abstract Epilepsy is primarily defined by the repetitive occurrence of seizures, but the full impact of seizures extends beyond these episodic events. Seizures themselves cause changes at the cellular, network, and systemic levels in individual patients with epilepsy and may contribute to the progressive nature of the disease in some patients. Seizures
Matthew C. Walker, Marian Galovic, Elena Álvarez‐Barón, Adam Strzelczyk   +3 more
wiley   +1 more source

The Effects of NMDA Receptor Blockade on Sensory-Evoked Responses in Superficial Layers of the Rat Barrel Cortex

Frontiers in Cellular Neuroscience, 2019
Transmission of excitation from L4 to L2/3 is a part of a canonical circuit of cortical sensory signal processing. While synapses from L4 to L2/3 are mediated by both AMPA and NMDA glutamate receptors, previous studies suggested that sensory-evoked ...
Julia Lebedeva, Andrey Zakharov, Andrey Zakharov, Gulshat Burkhanova, Kseniya Chernova, Roustem Khazipov, Roustem Khazipov   +6 more
doaj   +1 more source

Erratum: Corrigendum: NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones [PDF]

, 1986
Amy B. MacDermott, Mikaël Meyer, GL Westbrook, S. J. Smith, J L Barker   +4 more
openalex   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source