Results 161 to 170 of about 217,671 (368)

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Nutraceuticals and COVID‐19: A mechanistic approach toward attenuating the disease complications

Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022
Abstract Nutraceuticals have emerged as potential compounds to attenuate the COVID‐19 complications. Precisely, these food additives strengthen the overall COVID treatment and enhance the immunity of a person. Such compounds have been used at a large scale, in almost every household due to their better affordability and easy access.
Keshav Raj Paudel, Vyoma Patel, Sukriti Vishwas, Saurabh Gupta, Sumit Sharma, Yinghan Chan, Niraj Kumar Jha, Jesus Shrestha, Mohammad Imran, Nisha Panth, Shakti Dhar Shukla, Saurav Kumar Jha, Hari Prasad Devkota, Majid Ebrahimi Warkiani, Sachin Kumar Singh, Md Khadem Ali, Gaurav Gupta, Dinesh Kumar Chellappan, Philip M. Hansbro, Kamal Dua   +19 more
wiley   +1 more source

Neural integrator - a sandpile model [PDF]

arXiv, 2006
We investigated a model for the neural integrator based on hysteretic units connected by positive feedback. Hysteresis is assumed to emerge from the intrinsic properties of the cells. We consider the recurrent networks containing either bistable or multistable neurons.
arxiv  

Quisqualate‐ and NMDA‐sensitive [³H]glutamate binding in primate brain [PDF]

, 1990
A. B. Young, George W. Dauth, Zane Hollingsworth, John B. Penney, Kevin W. Kaatz, S. Gilman   +5 more
openalex   +1 more source

Statins' protective effects on focal epilepsy are independent of LDL‐C

Epilepsia Open, EarlyView.
Abstract Objective This study evaluates the potential protective effects of statins against epilepsy, focusing on their differential impacts on focal and generalized epilepsy. It investigates the role of statins through the HMGCR gene and associated low‐density lipoprotein (LDL) cholesterol levels.
Zhen Sun, Jing Zhang, Yulong Li, Miao Tuo, Limin Yu, Yun Wang, Yanping Sun   +6 more
wiley   +1 more source

Tau‐targeting nanoparticles for treatment of Alzheimer's disease

Exploration, EarlyView.
Through review of comprehensive literature and research studies, it is found that tau‐targeting nanoparticles may posit beneficial applications to AD therapy. By targeting a key molecular mechanism known to propagate AD pathogenesis, tau‐targeting nanoparticles have the potential to facilitate tau tangle clearance, promote synaptic integrity, and ...
Shreya Pawar, Mohd Ahmar Rauf, Hosam Abdelhady, Arun K. Iyer   +3 more
wiley   +1 more source

Ibudilast Protects Retinal Bipolar Cells From Excitotoxic Retinal Damage and Activates the mTOR Pathway. [PDF]

Glia
Main Points Ibudilast, a MIF and PDE inhibitor, preserves the form and function of the retina, especially bipolar cells, during excitotoxic damage. Ibudilast upregulates multiple signaling pathways, including mTOR, in damaged Müller glia and bipolar cells.
Hamadmad S, Heisler-Taylor T, Goswami S, Hawthorn E, Chaurasia S, Martini D, Summitt D, Zatari A, Shalash R, Sohail M, Urbanski EG, Bernstein K, Racine J, Satoskar A, El-Hodiri HM, Fischer AJ, Cebulla CM.   +16 more
europepmc   +2 more sources

On Transition Metal Catalyzed Reduction of N-nitrosodimethlamine [PDF]

arXiv, 2014
This report provides a critical review on "Metal-Catalyzed Reduction of N-Nitrosodimethylamine with Hydrogen in Water", by Davie et al. N-nitrosodimethlamine (NDMA) is a contaminant in drinking and ground water which is difficult to remove by conventional physical methods, such as air stripping.
arxiv  

NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat [PDF]

, 1990
Lovinger Dm, Gentry White, FF Weight
openalex   +1 more source

Developmental transcriptomes predict adult social behaviours in the socially flexible sweat bee, Lasioglossum baleicum

Molecular Ecology, EarlyView., 2023
Abstract Natural variation can provide important insights into the genetic and environmental factors that shape social behaviour and its evolution. The sweat bee, Lasioglossum baleicum, is a socially flexible bee capable of producing both solitary and eusocial nests.
Kennedy S. Omufwoko, Adam L. Cronin, Thi Thu Ha Nguyen, Andrew E. Webb, Ian M. Traniello, Sarah D. Kocher   +5 more
wiley   +1 more source