Results 181 to 190 of about 110,732 (265)

Calcium signaling and postsynaptic density dynamics: the roles of calmodulin in synaptic protein regulation. [PDF]

Front Mol Neurosci
Shah KD, Zhang Y.
europepmc   +1 more source

Reprogramming Glial Cell Metabolism via a tRNA Fragment Preserves Vision in Retinal Neurodegeneration

MedComm, Volume 7, Issue 8, August 2026.
Under oxidative and excitotoxic stress, Müller cell‐derived 5′tiRNA‐His‐GTG contributes to retinal neurodegeneration. Pathological stimuli increase ANG‐dependent production of 5′tiRNA‐His‐GTG, which suppresses LPCAT1 expression and disrupts phosphatidylcholine (PC)‐mediated glycerophospholipid metabolism.
Yuke Ji, Sha Liu, Ying Zhang, Junya Zhu, Chang Huang, Ya Zhao, Jiao Xia, Wan Mu, Jin Yao, Biao Yan   +9 more
wiley   +1 more source

Ketamine Induces Apoptosis and Inhibits Proliferation in HT-29 Colorectal Cancer Cells. [PDF]

Biomedicines
Korkmaz IF, Elgun T, Aktas Ç, Gündeğer E, Yurttas AG.   +4 more
europepmc   +1 more source

The JAK1/2 Inhibitor Baricitinib Ameliorates Neuroinflammation and Symptoms in an Animal Model of Essential Tremor

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
In a harmaline‐induced essential tremor mouse model, baricitinib attenuated tremor severity and affective‐like abnormalities, suppressed cerebellar TNF‐α, IL‐6, NF‐κB, and Lingo‐1 expression, and showed supportive Purkinje‐cell morphological preservation.
Mehran Ilaghi, Fatemeh Shahsavari, Monavareh Soti, Sina Elyasifar, Leila Bagherzadeh, Zeynab Pirmoradi, Mohammad Shabani   +6 more
wiley   +1 more source

Hierarchical Afferent Connectivity Drives Population-Wide Bursting Dynamics in a Computational Model of Human-Derived Excitatory Neuronal Networks. [PDF]

J Neurosci
Barabino V, Callegari F, Martinoia S, Massobrio P.   +3 more
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation. [PDF]

EMBO Rep
Park DH, Ahn SY, Kim J, Choi J, Lee S, Kang M, Song JM, Suh YH.   +7 more
europepmc   +1 more source

HNRNPC Succinylation Influences the Neurodegeneration of Alzheimer's Disease Through YME1L1‐Mediated Mitochondrial Metabolism

Aging Cell, Volume 25, Issue 8, August 2026.
In Alzheimer's disease, SIRT5 downregulation enhances TRIM25‐mediated succinylation of HNRNPC at K50, increasing its stability. Stabilized HNRNPC upregulates YME1L1 expression via an m6A‐dependent mechanism, leading to OPA1 hydrolysis dysregulation, mitochondrial fission‐fusion imbalance, ROS overproduction, and neuronal death.
Xuewei Li, Fan Yang, Yuyan Jiang, Fei Zhao, Fan Liu   +4 more
wiley   +1 more source

Memantine prevents acute stress‐induced memory deficits by reversing sex‐dependent pathophysiological glutamatergic alterations in the dorsal hippocampus

British Journal of Pharmacology, Volume 183, Issue 16, Page 4939-4952, August 2026.
Abstract Background and Purpose The neural mechanisms underlying effects of acute stress on memory are poorly understood. We demonstrated previously that acute stress produces identical spatial memory deficits in male and female mice but through distinct molecular mechanisms, with females exhibiting up‐regulation of N‐methyl‐D‐aspartate (NMDA) receptor
Sebastiano A. Torrisi, Lidia Diolosà, Giuseppe Aceto, Claudia Marchetti, Federica Geraci, Konstantinos Partsinevelos, Silvia Rizzo, Margherita Grasso, Filippo Caraci, Francesco Bellia, Giovanni Li Volti, Angela Maria Amorini, Marcello D′Ascenzo, Gian Marco Leggio   +13 more
wiley   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source