Hierarchical Afferent Connectivity Drives Population-Wide Bursting Dynamics in a Computational Model of Human-Derived Excitatory Neuronal Networks. [PDF]
J NeurosciBarabino V +3 more
europepmc +1 more source
Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders
Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 698-710, June 2026.5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley +1 more source
Brain and Behavior, Volume 16, Issue 6, June 2026.In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence +14 more
wiley +1 more source
Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation. [PDF]
EMBO RepPark DH +7 more
europepmc +1 more source
Hydranencephaly in Neonate With Prenatal Exposure to Alcohol During Pregnancy
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Hydranencephaly (HE) is a rare congenital condition characterized by near‐total absence of the cerebral hemispheres, replaced by cerebrospinal fluid, most commonly resulting from in utero bilateral internal carotid artery occlusion; although maternal alcohol consumption is associated with fetal neurodevelopmental abnormalities, its direct role
Dibya Raj Chaudhary +3 more
wiley +1 more source
Alterations in the Components of the GABA-Glutamate System During ZIKV Infection: A Neuroscience Approach. [PDF]
Int J Mol SciRengifo AC +9 more
europepmc +1 more source
Neuroprotective Effects of Phenothiazines on Acute Ischemic Stroke
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.For acute ischemic stroke due to large vessel occlusion, adjunctive neuroprotective therapy with mechanical thrombectomy is important; however, current treatment options are relatively limited. Phenothiazines such as chlorpromazine and promethazine (C + P) have shown potential neuroprotective effects in preclinical studies.
Qi Wang +4 more
wiley +1 more source
Progress of Immunotherapies in Parkinson's Disease
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng +10 more
wiley +1 more source
Case Report: Oral glutamatergic augmentation for trauma-related disorders with fluoxetine-/bupropion-potentiated dextromethorphan ± piracetam: a four-patient case series. [PDF]
Front PsychiatryCheung N.
europepmc +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This prospective study shows that 6 months of lecanemab treatment significantly reduces brain amyloid load and improves neuropsychiatric symptoms in early Alzheimer's disease. These improvements are linked to amyloid clearance and structural changes in emotion‐related brain regions, indicating benefits beyond cognition.
Yan Chang +22 more
wiley +1 more source