Results 161 to 170 of about 110,732 (265)

Topical eye treatment with JGRi1, a protein/protein interaction inhibitor, mitigates retinal degeneration. [PDF]

Cell Death Dis
Cimino M, Serkiz J, Konstantopoulos JK, Tisi A, Cappelletti P, Maccarrone R, Sappington RM, Feligioni M.   +7 more
europepmc   +1 more source

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

Magnesium at the Neurovascular Interface: A Narrative Review of Atherosclerosis, Peripheral Arterial Disease, and Neuropathic Pain. [PDF]

Nutrients
Yoon Y, Park R, Shim J, Park J, Hwang J, Kim J, Lam KHS, Suryadi T, Suhaimi A.   +8 more
europepmc   +1 more source

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

Drug Testing and Analysis, Volume 18, Issue 8, Page 1036-1053, August 2026.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler, Tobias Veit, Thomas Keller, Volker Auwärter   +3 more
wiley   +1 more source

Kelulut honey (<i>Heterotrigona itama</i>) as a multi-target neuroprotective strategy against bisphenol A-induced neurotoxicity. [PDF]

Toxicol Rep
Azmi SK, Ali NF, Siran R.
europepmc   +1 more source

Mechanisms Underlying Pain Avoidance in Complex Regional Pain Syndrome

European Journal of Pain, Volume 30, Issue 7, August 2026.
ABSTRACT Background Maladaptive pain avoidance plays a critical role in chronic pain development and maintenance. Pain avoidance reinforced instrumentally through action‐outcome contingencies remains poorly understood, specifically in complex regional pain syndrome (CRPS), a nociplastic condition.
Raghavan Gopalakrishnan, Nitesh Singh Malan, Claire Sonneborn, Olivia Hogue, Pavan Tankha, Sylvain Baillet, Mathieu Roy   +6 more
wiley   +1 more source

Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico. [PDF]

PLoS Comput Biol
Rosanally S, Mazza F, Yao HK, Moghbel F, Seo H, Hay E.   +5 more
europepmc   +1 more source

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, Volume 11, Issue 4, Page 1095-1110, August 2026.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Autism-linked protein POSH balances NMDAR signaling via a self-limiting kinase-scaffold loop. [PDF]

iScience
Yao M, Wang S, Zhang F, Shi L, Xu Z.
europepmc   +1 more source