Results 171 to 180 of about 240,251 (364)
The Sharpey‐Schafer Prize Lecture. The mechanism of induction of NMDA receptor‐dependent long‐term potentiation in the hippocampus [PDF]
, 1992 Graham L. Collingridge
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Aging Cell, EarlyView.This schematic illustration summarizes the effects of calcium alpha‐ketoglutarate (CaAKG) on synaptic plasticity in a mouse model of Alzheimer's disease (APP/PS1). CaAKG enhances autophagy and restores LTP in APP/PS1 mice via NMDAR‐independent, LTCC, and CPAMPAR‐dependent pathways.
Sheeja Navakkode, Brian K. Kennedy
wiley +1 more source
NMDA-induced lesions of the amygdaloid complex block the retention-enhancing effect of posttraining epinephrine [PDF]
, 1991 Labry Cahill, James L. McGaugh
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Acta Psychiatrica Scandinavica, EarlyView.ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian +3 more
wiley +1 more source
Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review
Addiction, EarlyView.Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper +7 more
wiley +1 more source
The effect of centrally acting myorelaxants on NMDA receptor‐mediated synaptic transmission in the immature rat spinal cord in vitro [PDF]
, 1992 Richard J. Siarey +2 more
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Anaesthesia, EarlyView.Summary Introduction Postoperative delirium is a common complication following cardiac surgery. Despite its known impact on patient outcomes, effective preventative strategies remain elusive. We aimed to perform a comprehensive Bayesian network meta‐analysis of randomised controlled trials assessing the effect of pharmacological interventions on the ...
Ivo Queiroz +16 more
wiley +1 more source
Analgesia for Thoracic Surgery: Does Intraoperative Methadone Deserve a Place?
ANZ Journal of Surgery, EarlyView.Intraoperative methadone: potential benefits and considerations for thoracic surgery analgesia.
Eugene Constantine Lai +5 more
wiley +1 more source
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder
British Journal of Pharmacology, EarlyView.Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander +5 more
wiley +1 more source