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Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.
Science, 1995The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent ...
H. Kornau +3 more
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Current Opinion in Neurobiology, 2004
Dynamic modulation of the number of postsynaptic glutamate receptors is considered one of the main mechanisms for altering the strength of excitatory synapses in the central nervous system (CNS). However, until recently N-methyl-d-aspartate (NMDA) receptors were considered relatively stable once in the plasma membrane, especially in comparison with ...
Yue-Qiao Huang +2 more
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Dynamic modulation of the number of postsynaptic glutamate receptors is considered one of the main mechanisms for altering the strength of excitatory synapses in the central nervous system (CNS). However, until recently N-methyl-d-aspartate (NMDA) receptors were considered relatively stable once in the plasma membrane, especially in comparison with ...
Yue-Qiao Huang +2 more
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Synapse, 1991
AbstractIdentified crayfish visual interneurons respond to illumination with a compound EPSP of up to 40 mV. L‐gultamate, quisqualate, and kainate mimic the depolarizing action of the natural transmitter. In reduced Mg2+, N‐methyl‐D‐aspartate (NMDA) elicits a depolarization with a reversal potential (Erev) = −60 mV. Erev is independent of extracellular
Cindy Pfeiffer-Linn, Raymon M. Glantz
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AbstractIdentified crayfish visual interneurons respond to illumination with a compound EPSP of up to 40 mV. L‐gultamate, quisqualate, and kainate mimic the depolarizing action of the natural transmitter. In reduced Mg2+, N‐methyl‐D‐aspartate (NMDA) elicits a depolarization with a reversal potential (Erev) = −60 mV. Erev is independent of extracellular
Cindy Pfeiffer-Linn, Raymon M. Glantz
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Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain.
Science, 1999Programmed cell death (apoptosis) occurs during normal development of the central nervous system. However, the mechanisms that determine which neurons will succumb to apoptosis are poorly understood.
C. Ikonomidou +9 more
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Mechanisms of NMDA receptor regulation
Current Opinion in Neurobiology, 2023N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key role in brain development and plasticity. On the downside, NMDAR dysfunction, be it hyperactivity or hypofunction, is harmful to neuronal function and has emerged as a common theme in various neuropsychiatric disorders ...
Mony, Laetitia, Paoletti, Pierre
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NMDA receptors and schizophrenia
Current Opinion in Pharmacology, 2007The pathophysiology of schizophrenia is poorly understood but is likely to involve alterations in excitatory glutamatergic signaling molecules in several areas of the brain. Clinical and experimental evidence has shown that expression of the N-methyl-D-aspartate (NMDA) receptor and intracellular NMDA receptor-interacting proteins of the glutaminergic ...
James H. Meador-Woodruff +3 more
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NMDA Receptor Antagonists and Glycine Site NMDA Antagonists
Current Medical Research and Opinion, 2002Extracellular concentrations of excitatory amino acids increase substantially within cerebral tissue beds exposed to ischaemic conditions. This leads to excessive stimulation of N-methyl-D-aspartate (NMDA) receptors, a major cerebral excitatory neurotransmitter receptor that likely plays a critical role in the propagation of ischaemic injury in neurons.
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Annual Review of Pharmacology and Toxicology, 2003
The NMDA receptor (NMDAR) plays a central role in the function of excitatory synapses. Recent studies have provided interesting insights into several aspects of the trafficking of this receptor in neurons. The NMDAR is not a static resident of the synapse. Rather, the number and composition of synaptic NMDARs can be modulated by several factors.
Steve Standley +4 more
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The NMDA receptor (NMDAR) plays a central role in the function of excitatory synapses. Recent studies have provided interesting insights into several aspects of the trafficking of this receptor in neurons. The NMDAR is not a static resident of the synapse. Rather, the number and composition of synaptic NMDARs can be modulated by several factors.
Steve Standley +4 more
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A Fast Synaptic Potential Mediated by NMDA and Non-NMDA Receptors
Journal of Neurophysiology, 1997Wolszon, Laura R., Alberto E. Pereda, and Donald S. Faber. A fast synaptic potential mediated by NMDA and non-NMDA receptors. J. Neurophysiol. 78: 2693–2706, 1997. Excitatory synaptic transmission in the CNS often is mediated by two kinetically distinct glutamate receptor subtypes that frequently are colocalized, the N-methyl-d-aspartate (NMDA) and ...
Alberto E. Pereda +2 more
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NMDA retseptorsüsteemid NMDA retseptorsüsteemid
2009N-metüül-D-aspartaadi (NMDA) retseptorite kaudu toimuv kaltsiumiioonide sissevool närvirakkudesse on vajalik närvisüsteemis toimuvateks füsioloogilisteks protsessideks. Selle süsteemi üleaktivatsiooni tingimustes suureneb markantselt postsünaptilistes neuronites intratsellullarse Ca2+ hulk ning see on neuronite degeneratsiooni üks võtmeprotsesse. Selle
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