Results 51 to 60 of about 217,671 (368)
The effects of memantine on prepulse inhibition. [PDF]
, 2009 Reduced prepulse inhibition (PPI) of startle provides evidence of deficient sensorimotor gating in several disorders, including schizophrenia. The role of NMDA neurotransmission in the regulation of PPI is unclear, due to cross-species differences in the
Bergsma, F +4 more
core +2 more sources
Alzheimer’s Research & Therapy, 2021 Background The cannabinoid CB2 receptor (CB2R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which are key in mediating excitatory neurotransmission, are expressed in both neurons and glia ...
Rafael Rivas-Santisteban +7 more
doaj +1 more source
The Dichotomy of NMDA Receptor Signaling [PDF]
The Neuroscientist, 2007 The N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors plays a Jekyll and Hyde role in the mammalian central nervous system. In pathological scenarios such as ischemia, Ca2+ influx through the NMDA receptor is a key mediator of cell death.
Papadia, Sofia, Hardingham, Giles
openaire +4 more sources
Differential Actions of Ethanol and Trichloroethanol at Sites in the M3 and M4 Domains of the NMDA Receptor GluN2A (NR2A) Subunit [PDF]
, 2009 Background and purpose: Alcohol produces its behavioural effects in part due to inhibition of N-methyl-d-aspartate (NMDA) receptors in the CNS. Previous studies have identified amino acid residues in membrane-associated domains 3 (M3) and 4 (M4) of the ...
Hu, Xiang-Qun +5 more
core +3 more sources
Intersubunit Cooperativity in the NMDA Receptor [PDF]
Neuron, 2001 Opening of the NMDA receptor channel requires simultaneous binding of glutamate and glycine. Although the binding sites for each agonist are in different subunits, the presence of one agonist influences the binding of the other. We have localized regions in the S1 binding domain of both subunits required for the transmission of allosteric signals from ...
Regalado, M. Paz +2 more
openaire +4 more sources
Journal of Pain Research, 2023 Laksono RM, Kalim H, Rohman MS, Widodo N, Ahmad MR, Halim W. J Pain Res. 2023;16:1697–1711. The authors have advised affiliation 1 on page 1697 is incorrect.
Laksono RM +5 more
doaj
Food Science &Nutrition, Volume 11, Issue 1, Page 249-260, January 2023., 2023 This study indicated, for the first time, that (±) linalool and its enantiomer, (R)‐(‐) linalool protected PC12 cells against injury induced by oxygen and glucose deprivation/reoxygenation (OGD/R) via the mitigation of oxidative stress and the downregulation of Bax/Bcl‐2, caspase‐3 and caspase‐9, resulting in decreased apoptotic cell death.
Azar Hosseini +5 more
wiley +1 more source
Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]
Physical Review E 82, 041902 (2010), 2010 The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv +1 more source
SynGAP Regulates Steady-State and Activity-Dependent Phosphorylation of Cofilin [PDF]
, 2008 SynGAP, a prominent Ras/Rap GTPase-activating protein in the postsynaptic density, regulates the timing of spine formation and trafficking of glutamate receptors in cultured neurons.
Carlisle, Holly J. +3 more
core +3 more sources
Glia, Volume 71, Issue 2, Page 229-244, February 2023., 2023 Main Points Gray and white matter astrocytes have different basal NADH/NAD+ redox states and ATP levels. Metabolism of both cell populations responds similarly to neuronal activity. Glutamate induced ATP loss is prevented by increasing extracellular K+.
Susanne Köhler +5 more
wiley +1 more source