A quantitative method to assess extrasynaptic NMDA receptor function in the protective effect of synaptic activity against neurotoxicity [PDF]
BMC Neuroscience, 2008 Background Extrasynaptic NMDA receptors couple to a CREB shut-off pathway and cause cell death, whereas synaptic NMDA receptors and nuclear calcium signaling promote CREB-mediated transcription and neuronal survival.
Bading Hilmar +2 more
doaj +5 more sources
High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]
Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016 NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
Scheppach, Christian
arxiv +3 more sources
Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-D-aspartate currents by dopamine D1 receptor activation in striatum [PDF]
Frontiers in Systems Neuroscience, 2011 Dopamine, via activation of D1 receptors, enhances N-methyl-D-aspartate (NMDA) receptor-mediated responses in striatal medium-sized spiny neurons. However, the role of specific NMDA receptor subunits in this enhancement remains unknown.
Emily L Jocoy +8 more
doaj +8 more sources
Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state [PDF]
BMC Neuroscience, 2005 Background The N-methyl-D-aspartate (NMDA)-type glutamate receptor expressed at excitatory glutamatergic synapses is required for learning and memory and is critical for normal brain function.
Hanson Jesse E +3 more
doaj +4 more sources
Slowly developing depression of N-methyl-D-aspartate receptor mediated responses in young rat hippocampi [PDF]
BMC Neuroscience, 2004 Background Activation of N-methyl-D-aspartate (NMDA) type glutamate receptors is essential in triggering various forms of synaptic plasticity. A critical issue is to what extent such plasticity involves persistent changes of glutamate receptor subtypes ...
Jilderos Barbro +4 more
doaj +4 more sources
N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors [PDF]
Alzheimer’s Research & Therapy, 2021 Background The cannabinoid CB2 receptor (CB2R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which are key in mediating excitatory neurotransmission, are expressed in both neurons and glia ...
Rafael Rivas-Santisteban +7 more
doaj +2 more sources
Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors [PDF]
Frontiers in Molecular Neuroscience, 2016 NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li +15 more
doaj +4 more sources
Integrated Regulation of Signal Coding and Plasticity by NMDA Receptors at a Central Synapse [PDF]
Neural Plasticity, 1998 The role of NMDA and non-NMDA glutamate receptors in long-term potentiation has been intensely investigated, yet recent evidence on the dynamics of synaptic depolarization suggests that the original view should be extended.
Egidio D'Angelo, Paola Rossi
doaj +4 more sources
NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation [PDF]
Journal of NeuroinflammationNeurodegeneration and neuroinflammation are key components in the pathogenesis of Japanese Encephalitis caused by Japanese Encephalitis Virus (JEV) infection.
Cheng-Yi Chang +8 more
doaj +2 more sources
Dual regulation by ethanol of the inhibitory effects of ketamine on spinal NMDA-induced pressor responses in rats [PDF]
Journal of Biomedical Science, 2012 Background Acute exposure of ethanol (alcohol) inhibits NMDA receptor function. Our previous study showed that acute ethanol inhibited the pressor responses induced by NMDA applied intrathecally; however, prolonged ethanol exposure may increase the ...
Keng Nien-Tzu +4 more
doaj +5 more sources