Results 1 to 10 of about 22,217 (292)
Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions
Frontiers in Pharmacology, 2022 Excessive activation of N-methyl-d-aspartic acid (NMDA) receptors after cerebral ischemia is a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx is a necessary condition for ischemic injury mediated by NMDA ...
Yuanyuan Li +20 more
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NMDA Receptors in Astrocytes [PDF]
Neurochemical Research, 2019 Astrocytes support glutamatergic neurotransmission in the central nervous system through multiple mechanisms which include: (i) glutamate clearance and control over glutamate spillover due to operation of glutamate transporters; (ii) supply of obligatory glutamate precursor glutamine via operation of glutamate-glutamine shuttle; (iii) supply of L ...
Alexandr Chvátal +3 more
openaire +6 more sources
Biomolecules, 2022 Various ASD risk alleles have been associated with impairment of NMDA receptor activation (i.e., NMDA Receptor Hypofunction) and/or disturbance of the careful balance between activation mediated by GluN2B-subtype and GluN2A-subtype-containing NMDA ...
Stephen I. Deutsch +2 more
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Bortezomib in the management of anti-NMDA receptor encephalitis
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2023 Background Anti-N-methyl d-aspartate (NMDA) receptor encephalitis is an autoimmune encephalitis characterized by neuronal surface antibodies targeting NMDA receptor in the spinal fluid and serum.
Bryan Gervais de Liyis +6 more
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Blockade of the N-Methyl-D-Aspartate Glutamate Receptor Ameliorates Lipopolysaccharide-Induced Renal Insufficiency. [PDF]
PLoS ONE, 2015 N-methyl-D-aspartate (NMDA) receptor activation in rat kidney reduces renal perfusion and ultrafiltration. Hypoperfusion-induced ischemia is the most frequent cause of functional insufficiency in the endotoxemic kidney.
Chian-Shiung Lin +3 more
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COVID−19, Anti-NMDA Receptor Encephalitis and MicroRNA
Frontiers in Immunology, 2022 The coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on the world, affecting people’s lifestyle, economy, and livelihood. Recently, with the development of vaccines, the number of infected cases has decreased.
Hsiuying Wang
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Accuracy in readout of glutamate concentrations by neuronal cells [PDF]
The European Physical Journal E, 46(4), 30 (2023), 2023 Glutamate and glycine are important neurotransmitters in the brain. An action potential prop- agating in the terminal of a presynatic neuron causes the release of glutamate and glycine in the synapse by vesicles fusing with the cell membrane, which then activate various receptors on the cell membrane of the post synaptic neuron.
arxiv +1 more source
Memory and the NMDA Receptors [PDF]
New England Journal of Medicine, 2009 Ablating mice of Neto1, a component that stabilizes a postsynaptic glutamate receptor, results in a deficit in memory and learning — a deficit ameliorated by administration of a glutamate-receptor stimulant.
Joe Z. Tsien, Fei Li
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NMDA Receptor Modulators in the Treatment of Drug Addiction
Pharmaceuticals, 2013 Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function,
M. Foster Olive +3 more
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Alzheimer’s Research & Therapy, 2021 Background The cannabinoid CB2 receptor (CB2R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which are key in mediating excitatory neurotransmission, are expressed in both neurons and glia ...
Rafael Rivas-Santisteban +7 more
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