Results 181 to 190 of about 22,217 (292)

Synaptic Basis of Cortical Persistent Activity: the Importance of NMDA Receptors to Working Memory [PDF]

, 1999
Xiao‐Jing Wang
openalex   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Evidence for more than one type of non‐NMDA receptor in outside‐out patches from cerebellar granule cells of the rat.

, 1993
David J. A. Wyllie, Stephen F. Traynelis, Stuart Cull-Candy   +2 more
openalex   +2 more sources

Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases [PDF]

, 1996
Martin Niethammer, Eugene Kim, Morgan Sheng   +2 more
openalex   +1 more source

Characterization of the Cerebroprotective Efficacy of the Competitive NMDA Receptor Antagonist CGP40116 in a Rat Model of Focal Cerebral Ischemia: An in vivo Magnetic Resonance Imaging Study

, 1993
Dirk Sauer, Peter R. Allegrini, Alexandra Cosenti, A. Pataki, Hugo Amacker, Graham E. Fagg   +5 more
openalex   +1 more source

Evidence for a Tetrameric Structure of Recombinant NMDA Receptors [PDF]

, 1998
Bodo Laube, Jochen Kuhse, Heinrich Betz
openalex   +1 more source

Mediators of epilepsy risk after traumatic brain injury: A 20‐year U.S. veteran cohort study

Epilepsia, EarlyView.
Abstract Objective Traumatic brain injury (TBI) is a significant risk factor for epilepsy, but little work has explored whether risk of epilepsy after TBI may operate through intermediary mechanisms. The objective of this study was to statistically screen for potentially mediating effects among 64 comorbidities for epilepsy risk following TBI among ...
Shashank Vadlamani, Mustafa Ozmen, James J. Gugger, Amanda Cheney, Megan Amuan, Ramon Diaz‐Arrastia, Mary Jo Pugh, Eamonn Kennedy   +7 more
wiley   +1 more source

Memantine, a noncompetitive NMDA receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats [PDF]

, 1997
Birgit A. P. M. Vogels, M.A.W. Maas, Joost Daalhuisen, G. Quack, Robert A.F.M. Chamuleau   +4 more
openalex   +1 more source

Plasma metabolome reveals altered oxidative stress, inflammation, and amino acid metabolism in dogs with idiopathic epilepsy

Epilepsia, EarlyView.
An overview of the study protocol including 88 client‐owned dogs: 39 healthy controls (HC), 22 dogs with mild phenotype (MP) and 27 drug‐resistant (DR) idiopathic epilepsy. UHPLC‐HRMS, ultra‐high‐performance liquid chromatography coupled to hybrid quadrupole‐Orbitrap high resolution mass spectrometry Abstract Objective Idiopathic epilepsy (IE) is the ...
Fien Verdoodt, Sofie F. M. Bhatti, Jenifer Molina, Luc Van Ham, Lynn Vanhaecke, Greet Junius, Lieselot Y. Hemeryck, Myriam Hesta   +7 more
wiley   +1 more source

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat

Epilepsia, EarlyView.
Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo, Venkatesha Murthy, Mahnaz Asgharnejad, Arturo Benitez, Kosuke Nakashima, Nicole Hawkins, H. Steve White   +6 more
wiley   +1 more source