Results 21 to 30 of about 22,217 (292)
High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]
Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016 NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
arxiv +1 more source
A family of photoswitchable NMDA receptors [PDF]
eLife, 2016 NMDA receptors, which regulate synaptic strength and are implicated in learning and memory, consist of several subtypes with distinct subunit compositions and functional properties. To enable spatiotemporally defined, rapid and reproducible manipulation of function of specific subtypes, we engineered a set of photoswitchable GluN subunits ('LiGluNs ...
Stephanie Szobota +11 more
openaire +6 more sources
Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew
Journal of Comparative Neurology, Volume 531, Issue 3, Page 390-414, February 2023., 2023 The present work provides a quantitative dataset of synapses from the Etruscan shrew (the smallest known terrestrial mammal). We have identified common and differing principles of synaptic organization compared to other mammalian species. Abstract The main aim of the present study was to determine if synapses from the exceptionally small brain of the ...
Lidia Alonso‐Nanclares +8 more
wiley +1 more source
The Dichotomy of NMDA Receptor Signaling [PDF]
The Neuroscientist, 2007 The N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors plays a Jekyll and Hyde role in the mammalian central nervous system. In pathological scenarios such as ischemia, Ca2+ influx through the NMDA receptor is a key mediator of cell death.
Papadia, Sofia, Hardingham, Giles
openaire +4 more sources
Depression and Anxiety, Volume 39, Issue 12, Page 780-793, December 2022., 2022 Abstract Background Anxiety disorders emerge during childhood and adolescence and are frequently preceded by subsyndromal anxiety symptoms. Environmental toxicants, including gestational polybrominated diphenyl ether (PBDE) exposure, are associated with neuropsychiatric sequelae; however, the role of PBDEs as risk factors for anxiety in adolescence is ...
Jeffrey R. Strawn +9 more
wiley +1 more source
Journal of Biomedical Science, 2011 Background In order to understand the interaction between the metabotropic glutamate subtype 5 (mGluR5) and N-methyl-D-aspartate (NMDA) receptors, the influence of mGluR5 positive modulators in the inhibition of NMDA receptors by the noncompetitive ...
Liao Pei-Fei +2 more
doaj +1 more source
Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]
Physical Review E 82, 041902 (2010), 2010 The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv +1 more source
Structure and evolution of neuronal wiring receptors and ligands
Developmental Dynamics, Volume 252, Issue 1, Page 27-60, January 2023., 2023 Abstract One of the fundamental properties of a neuronal circuit is the map of its connections. The cellular and developmental processes that allow for the growth of axons and dendrites, selection of synaptic targets, and formation of functional synapses use neuronal surface receptors and their interactions with other surface receptors, secreted ...
Elena Cortés +2 more
wiley +1 more source
BMC Neuroscience, 2004 Background Activation of N-methyl-D-aspartate (NMDA) type glutamate receptors is essential in triggering various forms of synaptic plasticity. A critical issue is to what extent such plasticity involves persistent changes of glutamate receptor subtypes ...
Jilderos Barbro +4 more
doaj +1 more source
Tonic activation of extrasynaptic NMDA receptors decreases intrinsic excitability and promotes bistability in a model of neuronal activity [PDF]
Int J Mol Sci. 2019 Dec 27;21(1). pii: E206, 2018 NMDA receptors (NMDA-R) typically contribute to excitatory synaptic transmission in the central nervous system. While calcium influx through NMDA-R plays a critical role in synaptic plasticity, experimental evidence indicates that NMDAR-mediated calcium influx also modifies neuronal excitability through the activation of calcium-activated potassium ...
arxiv +1 more source