Results 101 to 110 of about 10,005 (213)

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Preliminary evaluation of NMN reprotoxicity using human sperm assay

Human spermatozoa are highly susceptible to oxidative injury owing to their polyunsaturated fatty acid-rich plasma membrane and limited antioxidant defenses.
Serajoddin Vahidi Mehrjardi, Tahereh Anjoman, Mahin Izadi, Mohammad Ebrahim Rezvani, Seyed Amir Shaker   +4 more
core   +1 more source

Differences in Extracellular NAD(+) and NMN Metabolism on the Surface of Vascular Endothelial Cells

, 2022
SIMPLE SUMMARY: Nicotinamide adenine dinucleotide (NAD(+)) is a multifunctional metabolite involved in many key cellular processes. Outside the cell, NAD(+) or its metabolites are important signaling molecules, related especially to calcium homeostasis ...
Alicja Braczko, Slominska, Ewa M., Tomczyk, Marta, Patrycja Jablonska, Marta Tomczyk, Marika Franczak, Smolenski, Ryszard T., Jablonska, Patrycja, Mierzejewska, Paulina, Braczko, Alicja, Patrycja Koszalka, Barbara Kutryb-Zajac, Kawecka, Ada, Ewa M. Slominska, Franczak, Marika, Paulina Mierzejewska, Ada Kawecka, Kutryb-Zajac, Barbara, Koszalka, Patrycja, Ryszard T. Smolenski   +19 more
core   +1 more source

Review on Biosynthesis of β-Nicotinamide Mononucleotide and Its Derivatives [PDF]

Shipin Kexue
β-Nicotinamide mononucleotide (NMN) is present in all organisms and has attracted widespread attention as a nutritional supplement and pharmaceutical product for the treatment of various diseases, such as Alzheimer’s disease, cancer, aging, and vascular ...
WANG Zhaoying, GUO Xinhao, HUANG Xinhe, CHEN Zhuoyan, LIU Yueqi, LI Juan, CHEN Ning, FAN Xiaoguang
doaj   +1 more source

A Global Compilation of Blue Whale Strandings

Marine Mammal Science, Volume 42, Issue 4, October 2026.
ABSTRACT Marine mammal strandings are common occurrences that attract public and scientific interest. Stranding data can provide important information for rarely sighted species, but while regional and national stranding databases do exist in some areas, cross‐database communication and data sharing are limited.
Kristina V. Randrup, Robert L. Brownell Jr., R. Charles Anderson, Emma L. Carroll, Rochelle Constantine, Barbara Galletti Vernazzani, Hannah Hendriks, Anouk D. Ilangakoon, Divya Panicker, Dipani Sutaria, Koen Van Waerebeek, Sarah M. Wilkin, Tonya Wimmer, Trevor A. Branch   +13 more
wiley   +1 more source

Systemic nicotinamide mononucleotide administration to mitigate post-cardiac arrest brain injury in mice.

PLoS ONE
Post-cardiac arrest brain injury (PCABI) is the leading cause of death and disability following cardiac arrest (CA). Nicotinamide adenine dinucleotide (NAD+) depletion after CA contributes to neuronal injury, while nicotinamide mononucleotide (NMN ...
Daiki Kaito, Tomoyoshi Tamura, Sayuri Suzuki, Ryutaro Onishi, Kenji F Tanaka, Jun Yoshino, Tadashi Matsuoka, Katsuya Maeshima, Junichi Sasaki, Koichiro Homma   +9 more
doaj   +1 more source

Nicotinamide mononucleotide rescues perinatal arsenic-induced autism-like behaviours via modulation of NAD+ metabolism in mice

Ecotoxicology and Environmental Safety
Recent epidemiological studies have indicated that exposure to arsenic (As), particularly during key phases of central nervous system development, may be an environmental risk factor for autism spectrum disorder (ASD).
Qin Lu, Changsong Tian, Lianrui Li, Xinmiao Liu, Jiahao Liu, Yan He, Aihua Zhang, Wenjuan Wang   +7 more
doaj   +1 more source

Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca2+ Influx but Only Modestly Influenced by Mitochondria [PDF]

, 2015
SummaryAxon injury leads to rapid depletion of NAD-biosynthetic enzyme NMNAT2 and high levels of its substrate, NMN. We proposed a key role for NMN in Wallerian degeneration but downstream events and their relationship to other mediators remain unclear ...
Di Stefano, Michele, Andrea Loreto, Loreto, Andrea, Michele Di Stefano, Gering, Martin, Martin Gering, Laura Conforti, Conforti, Laura   +7 more
core   +1 more source

Biosynthesis of β-nicotinamide mononucleotide from glucose via a new pathway in Bacillus subtilis

Frontiers in Microbiology
Introductionβ-nicotinamide mononucleotide (β-NMN) is an essential precursor of nicotinamide adenine dinucleotide (NAD+) and plays a key role in supplying NAD+ and maintaining its levels.
Zhilei Tan, Yihang Yang, Yannan Wu, Jiajia Yan, Bin Zhang, Ying Hou, Shiru Jia   +6 more
doaj   +1 more source

NMN administration reduces I/R injury.

, 2014
Either NMN (500 mg/kg per injection) or vehicle (PBS) was administered (i.p. injection) to mice according to one of four different protocols (Figure S4 in File S1), the mice were subjected to I/R, and the extent of I/R injury was evaluated with TTC ...
Takanobu Yamamoto (573966), Peiyong Zhai (212989), Junichi Sadoshima (106970), Jaemin Byun (573967), Yoshiyuki Ikeda (106953), Shinichi Oka (205454)   +5 more
core   +1 more source