Results 111 to 120 of about 10,005 (213)

Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men

Endocrine Journal
Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, declines in
Shintaro Yamaguchi, Junichiro Irie, Masanori Mitsuishi, Yuichi Uchino, Hideaki Nakaya, Ryo Takemura, Emi Inagaki, Shotaro Kosugi, Hideyuki Okano, Masato Yasui, Kazuo Tsubota, Kaori Hayashi, Jun Yoshino, Hiroshi Itoh   +13 more
doaj   +1 more source

Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD+/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging

Stem Cell Research & Therapy
Background Recently, the beneficial effects of human umbilical cord mesenchymal stromal cell (hucMSC)-derived small extracellular vesicles (sEVs) in mitigating skin aging through multiple mechanisms have been widely reported.
Zixuan Sun, Jiali Li, Yuzhou Zheng, Jiaxin Zhang, Wenhuan Bai, Xinyi Deng, Zhijing Wu, XueZhong Xu, Wei Ding, Hui Qian, Yulin Tan   +10 more
doaj   +1 more source

Nicotinamide Mononucleotide Modulates Endothelin-1 via NR4A1 and Histone Modifications in Canine Intestinal Epithelial Cells

Animals
This work conducted a transcriptome analysis of canine intestinal epithelial cells (cIECs) treated with nicotinamide mononucleotide (NMN), a physiologically active nucleotide with a pyridine base known for its anti-aging and anti-inflammatory effects. In
Xudong Guo, Chuyang Zhu, Saber Y. Adam, Cuipeng Zhu, Hao-Yu Liu, Demin Cai   +5 more
doaj   +1 more source

PRPP, ATP, and NMN are degraded in mouse blood plasma.

, 2013
PRPP, ATP, or NMN (150, 300, or 60 pmol, respectively) was incubated with the blood plasma (30 µl) in the presence of EDTA/EGTA at 4 (circles) or 37°C (triangles) or in the absence of the chelators at 37°C (squares) for the indicated times.
Nobumasa Hara (346840), Kazuo Yamada (36398), Mikako Tsuchiya (346843), Harumi Osago (346842), Tomoko Shibata (346841)   +4 more
core   +1 more source

Data set of: "The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila"

<p><span>This dataset contains all experiments published in doi: 10.7554/eLife.80245 (PMID: 36476387). I</span><span>t contains templates of different experiments, raw and analysed data, pictures, graphs, videos, and figures.< ...
Neukomm, Lukas, LLOBET ROSELL, ARNAU
core   +1 more source

Construction of Nicotinamide Mononucleotide-Loaded Liposomes and Their In Vitro Transport Across the Blood–Brain Barrier

Applied Sciences
Nicotinamide mononucleotide (NMN) possesses a variety of physiological functions and has therapeutic effects on cardio-cerebral diseases, senile degenerative diseases, neurodegenerative diseases, delayed aging, etc.
Tiantian Wang, Qi Wu, Lihong Wang, Tao Lan, Zhenyu Yun, Lin Zhao, Xi Wu   +6 more
doaj   +1 more source

β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways

Hereditas
Background Alcoholism is a significant contributor to the development of alcoholic liver disease, for which no universally accepted and effective treatment currently exists.
Xinxin Yang, Endian Zheng, Yuxian Lin, Haoyue Sun, Ji Zhang, Yingcong Yu   +5 more
doaj   +1 more source

Investigating the Effect of Homeopathic NMN on Cognition, Motor Function, and Mood of Drosophila malenogaster

only.Pure NMN, also known as β-Nicotinamide Mononucleotide, is a fast-dissolving homeopathic supplement that claims to increase longevity and promote healthy aging.
Kastner, Kaden, Luly, Wade, Nessan, Erica   +2 more
core   +2 more sources

Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise

Background β-Nicotinamide mononucleotide (NMN) inhibits acute inflammation in injured animal tissues.Aim We examined whether NMN supplementation attenuates inflammation induced by blood flow restriction-resistance exercise (BFR-exercise) in human ...
Huang, Chih-Yang, Kuo, Chia-Hua, Hui-Tai Yang, Chao, Kuo-Ching, Nicholls, Andrew, Kuei-Hung Chen, Yang, Hui-Tai, Condello, Giancarlo, Ye, Mengxin, Yu-Chieh Liao, Chih-Yang Huang, Kuo-Ching Chao, Luthfia Dewi, Dewi, Luthfia, Andrew Nicholls, Dai-Lin Yang, Mengxin Ye, Yang, Dai-Lin, Giancarlo Condello, Chen, Kuei-Hung, Liao, Yu-Chieh, Chia-Hua Kuo   +21 more
core   +1 more source

Nicotinamide mononucleotide attenuates hyperandrogenism in a polycystic ovary syndrome-like rat model by suppressing NLRP3 inflammasome–mediated granulosa-cell pyroptosis

Journal of Ovarian Research
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by ovarian dysfunction and hyperandrogenism. This study aimed to evaluate the therapeutic potential of nicotinamide mononucleotide (NMN) in reducing PCOS-associated ...
Yiwen Zhang, Kongwei Huang, Weihua Nong, Zhenwei Guo, Qin Xie, Xiaocan Lei, Shun Zhang, Meixiang Li, Jiaming Zhang   +8 more
doaj   +1 more source