Results 41 to 50 of about 880,423 (146)

A subchronic oral toxicity study of Salacia reticulata extract powder in rats

Toxicology Reports, 2015
The safety of Salacia plant (Salacia reticulata) extract powder, which is used in Ayurvedic medical practices, was studied in a dose range-finding subchronic toxicity study in Crl:CD Sprague–Dawley rats.
Yuriko Oda, Atsuko Yuasa, Fumitaka Ueda, Chihaya Kakinuma   +3 more
doaj   +1 more source

Edible Safety Evaluation of Cinnamomum camphora Seed Kernel Oil: Sub-Chronic Toxicity and Teratogenicity Assessments

Foods
Medium chain triglycerides (MCTs) are regarded as an important ingredient for functional foods and nutraceuticals. Cinnamomum camphora seed kernel oil (CCSKO) contains more than 95% medium chain fatty acids (MCFAs), which is a significantly higher level ...
Xianghui Yan, Ting Peng, Zheling Zeng, Pengbo Wang, Yifang Gao, Xuefang Wen, Jiaheng Xia, Deming Gong, Ping Yu   +8 more
doaj   +1 more source

A proposal for calculating the no-observed-adverse-effect level (NOAEL) for organic compounds responsible for liver toxicity based on their physicochemical properties

International Journal of Occupational Medicine and Environmental Health, 2014
Objectives: Both environmental and occupational exposure limits are based on the no-observed-adverse-effect level (NOAEL), lowest-observed-adverse-effect level (LOAEL) or benchmark dose (BMD) deriving from epidemiological and experimental studies.
Marek Jakubowski, Sławomir Czerczak
doaj   +1 more source

Toxicological Evaluation of Kenaf Seed Supercritical Carbon Dioxide-Oil in Male Sprague Dawley Rats

ASM Science Journal, 2021
Kenaf seed supercritical carbon dioxide oil (KSO-SFE) is known for its numerous health benefits such as high antioxidant activity, lower plasma cholesterol level, chemopreventive to cervical and colon cancer.
Siti Aisyah Abd Ghafar, Latifah Saiful Yazan, Sharida Fakhurazi, Maznah Ismail   +3 more
doaj   +1 more source

Bitter orange (Citrus aurantium L.) extract subchronic 90-day safety study in rats

Toxicology Reports, 2017
Bitter orange (Citrus aurantium L.) extracts are widely used in dietary supplements and bitter oranges are used in various juices and food products. p-Synephrine, the primary active constituent, comprises approximately 90% of total protoalkaloids.
N.S. Deshmukh, S.J. Stohs, C.C. Magar, A. Kale, B. Sowmya   +4 more
doaj   +1 more source

no observed adverse effect level

, 2014
Citation: 'no observed adverse effect level' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.NT06911 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +1 more source

Developmental and reproductive toxicity assessment of sporoderm-removed Ganoderma lucidum spores

Frontiers in Cell and Developmental Biology
IntroductionGanoderma lucidum is a fungus used in traditional Chinese medicine with high medicinal value and is also widely used in modern healthcare. Its spores are reported to contain antitumor and anti-inflammatory properties, among other biological ...
Junxiu Liu, Yisheng Song, Yisheng Song, Chuanhuai Chen, Jing Liu, Jing Liu, Siming Zhang, Fang Liu, Fang Liu, Ruiyu Tian, Jinjin Shao, Lili Zhang, Tingli Bian, Ruimin Sun, Li Yu, Shuizhen Pan, Yunxiang Chen, Yaoxian Xuan, Hanbo Wang, Zhenhao Li, Ying Chen, Lijiang Zhang, Lijiang Zhang   +22 more
doaj   +1 more source

Estimating the “First in human” dose – a revisit with particular emphases in oncology drugs

ADMET and DMPK, 2013
The initial dose selection is one of the important steps for any investigative new drug (IND) entering the first clinical study in human. In this mini review, we will discuss the no observed adverse effect level (NOAEL) and the minimum anticipated ...
Kin Tam
doaj   +1 more source

Efficacy of probiotics on stress in healthy volunteers: A systematic review and meta‐analysis based on randomized controlled trials

Brain and Behavior, 2020
Background Probiotics seems to play a beneficial role in stressed populations; thus, a systematic review and meta‐analysis to assess the effects of probiotics on stress in healthy subjects were conducted.
Ning Zhang, Yanan Zhang, Menglin Li, Weiguang Wang, Zhenzhu Liu, Chongcheng Xi, Xunying Huang, Jintao Liu, Junwei Huang, Dong Tian, Jie Mu, Xing Liao, Shuangqing Zhai   +12 more
doaj   +1 more source

Total cucurbitacins from Herpetospermum pedunculosum pericarp do better than Hu-lu-su-pian (HLSP) in its safety and hepatoprotective efficacy

Frontiers in Pharmacology
The pericarp of Herpetospermum pedunculosum (HPP) has traditionally been used for treating jaundice and hepatitis. However, the specific hepatoprotective components and their safety/efficacy profiles remain unclear.
Wen-Ya Liu, Di Xu, Zi-Yun Hu, Hui-Hui Meng, Qi Zheng, Feng-Ye Wu, Xin Feng, Jun-Song Wang   +7 more
doaj   +1 more source