Nocebo response intensity and influencing factors in the randomized clinical trials of irritable bowel syndrome: A systematic review and meta-analysis [PDF]
Frontiers in Medicine, 2022 ObjectiveTo estimate the magnitude of the nocebo response and explore its influencing factors in irritable bowel syndrome (IBS).MethodsThe PubMed, Embase, and Cochrane Library databases were searched up to March 2021.
Ruijie Li +9 more
doaj +4 more sources
The Placebo and Nocebo Responses in Clinical Trials in Inflammatory Bowel Diseases [PDF]
Frontiers in Pharmacology, 2021 Placebo and nocebo responses are mostly discussed in clinical trials with functional bowel disorders. Much less has been investigated and is known in gastrointestinal diseases beyond irritable bowel syndrome (IBS), especially in inflammatory bowel ...
Paul Enck, Sibylle Klosterhalfen
doaj +4 more sources
How the number of learning trials affects placebo and nocebo responses [PDF]
Pain, 2010 Conditioning procedures are used in many placebo studies because evidence suggests that conditioning-related placebo responses are usually more robust than those induced by verbal suggestions alone. However, it has not been shown whether there is a causal relation between the number of conditioning trials and the resistance to extinction of placebo and
Luana Colloca +2 more
exaly +6 more sources
Evidence of a Media-Induced Nocebo Response Following a Nationwide Antidepressant Drug Switch
Clinical Psychology in Europe, 2019 [Background] In 2017, patients on a generic or branded antidepressant venlafaxine were switched to a new generic formulation (Enlafax). In February and April 2018, two major NZ media outlets ran stories about the new generic being less effective ...
Kate MacKrill +4 more
doaj +4 more sources
No Reason to Feel Sick? Nocebo Responses in the Placebo Arms of Experimental Endotoxemia Studies [PDF]
Frontiers in Psychiatry, 2019 Adverse side effects are reported by a large proportion of patients undergoing medical treatment in clinical practice or clinical trials. Nocebo effects, induced by negative treatment expectancies, can contribute to negative patient-reported outcomes but
Sven Benson, Sigrid Elsenbruch
doaj +2 more sources
Brain Network to Placebo and Nocebo Responses in Acute Experimental Lower Back Pain: A Multivariate Granger Causality Analysis of fMRI Data [PDF]
Frontiers in Behavioral Neuroscience, 2021 Background and Objective: Placebo and nocebo responses are widely observed. Herein, we investigated the nocebo hyperalgesia and placebo analgesia responses in brain network in acute lower back pain (ALBP) model using multivariate Granger causality ...
Yu Shi +6 more
doaj +2 more sources
The High-Risk Model of Threat Perception Modulates Learning of Placebo and Nocebo Effects and Functional Somatic Disorders [PDF]
Brain SciencesThreat activation or deactivation in the brain–body is associated with learned nocebo or placebo somatic effects induced by fake invasive medical–surgical procedures.
Ian Wickramasekera
doaj +2 more sources
Placebo and the law of identification [PDF]
Frontiers in PsychiatryThousands of essays and studies have been published on placebo and nocebo. Yet, despite this plethora of information, we are not much closer to a comprehensive understanding of the fundamental mechanism producing placebo and nocebo effects than we were ...
Steve F. Bierman +2 more
doaj +2 more sources
Chicken or egg? Attribution hypothesis and nocebo hypothesis to explain somatization associated to perceived RF-EMF exposure [PDF]
Frontiers in Public HealthIntroductionThe aim of this study is to understand the temporal relationship between the somatization usually attributed to RF-EMFs, and to evaluate the attribution hypothesis and the nocebo hypothesis in this context.MethodIn this longitudinal study ...
S. Ariccio +6 more
doaj +2 more sources
Between placebo and nocebo: Response to control treatment is mediated by amygdala activity and connectivity. [PDF]
Eur J Pain, 2020 Egorova N +3 more
europepmc +3 more sources