Nocebo response intensity and influencing factors in the randomized clinical trials of irritable bowel syndrome: A systematic review and meta-analysis [PDF]
Frontiers in Medicine, 2022 ObjectiveTo estimate the magnitude of the nocebo response and explore its influencing factors in irritable bowel syndrome (IBS).MethodsThe PubMed, Embase, and Cochrane Library databases were searched up to March 2021.
Ruijie Li +9 more
doaj +5 more sources
Between placebo and nocebo: Response to control treatment is mediated by amygdala activity and connectivity. [PDF]
Eur J Pain, 2020 In experimental placebo and nocebo studies, neutral control treatments are often administered for comparison with active treatments, but are of little interest, as, on average, they result in little change.
Egorova N +3 more
europepmc +10 more sources
Evidence of a Media-Induced Nocebo Response Following a Nationwide Antidepressant Drug Switch
Clinical Psychology in Europe, 2019 [Background] In 2017, patients on a generic or branded antidepressant venlafaxine were switched to a new generic formulation (Enlafax). In February and April 2018, two major NZ media outlets ran stories about the new generic being less effective ...
Kate MacKrill +4 more
doaj +5 more sources
Nocebo hyperalgesia and the startle response [PDF]
Neuroscience, 2016 The literature on the effects of nocebo on pain is sparse. The present experimental study investigated whether suggestions of nocebo hyperalgesia modified the startle response and whether increased startle contributed to the nocebo hyperalgesic effect.A design with four groups was employed; the participants were randomized into either a placebo group ...
Per M. Aslaksen +3 more
semanticscholar +6 more sources
The influence of personality traits on the placebo/nocebo response [PDF]
Journal of Psychosomatic Research, 2019 Some people might be more prone to placebo and nocebo responses than others depending on their personality traits. We aimed to provide a systematic review on the influence of personality traits on placebo and nocebo responses in controlled and uncontrolled studies.We conducted a systematic literature search in the databases CINAHL, AMED, PsycINFO and ...
Alexandra Kern +3 more
semanticscholar +4 more sources
The Placebo and Nocebo Responses in Clinical Trials in Inflammatory Bowel Diseases [PDF]
Frontiers in Pharmacology, 2021 Placebo and nocebo responses are mostly discussed in clinical trials with functional bowel disorders. Much less has been investigated and is known in gastrointestinal diseases beyond irritable bowel syndrome (IBS), especially in inflammatory bowel ...
Paul Enck, Sibylle Klosterhalfen
doaj +5 more sources
No Reason to Feel Sick? Nocebo Responses in the Placebo Arms of Experimental Endotoxemia Studies [PDF]
Frontiers in Psychiatry, 2019 Adverse side effects are reported by a large proportion of patients undergoing medical treatment in clinical practice or clinical trials. Nocebo effects, induced by negative treatment expectancies, can contribute to negative patient-reported outcomes but
Sven Benson, Sigrid Elsenbruch
doaj +8 more sources
Trait responsiveness to verbal suggestions predicts nocebo responding: A meta-analysis. [PDF]
Br J Health Psychol, 2023 Nocebo responding involves the experience of adverse health outcomes in response to contextual cues. These deleterious responses impact numerous features of mental and physical health but are characterized by pronounced heterogeneity.
Stein MV +4 more
europepmc +3 more sources
Influence of the behaviour pattern on the nocebo response of healthy volunteers. [PDF]
British Journal of Clinical Pharmacology, 1995 The occurrence of a nocebo effect after placebo administration to healthy volunteers in a Phase I trial was analysed according to their type of personality (Bortner Rating Scale). More subjects with a behaviour pattern A (competitive and aggressive) (50%)
MD Drici +4 more
semanticscholar +6 more sources
Bad Is More Powerful than Good: The Nocebo Response in Medical Consultations [PDF]
The American Journal of Medicine, 2014 Although there has been a lot of research looking at the placebo response, nocebo responses in the healthcare setting have been largely overlooked. This article explores the potential role of negative patient-doctor communication in facilitating nocebo responses in the medical consultation. We suggest that invalidation, that is, communicating a lack of
Maddy Greville-Harris, Paul Dieppe
semanticscholar +7 more sources