Results 81 to 90 of about 5,065,669 (199)

Comparative Effectiveness Analysis of Phase 3 Clinical Trials in Moderately to Severely Active Inflammatory Bowel Disease Reveals Increased Harm From Placebo and Challenges Equipoise

JCC Plus, Volume 1, Issue 5, September 2026.
Across 47 Phase 3 trials in Crohn's disease and ulcerative colitis, placebo exposure was associated with measurable harm. Disease exacerbation events showed the greatest excess risk, with one additional exacerbation occurring for every 8–13 patients assigned to placebo rather than active therapy.
Joëlle St‐Pierre, Zachary D. Fine, Evan N. Fear, Jeremy A. Klein, Natalie K. Choi, David T. Rubin   +5 more
wiley   +1 more source

Conscious Expectation and Unconscious Conditioning in Analgesic, Motor, and Hormonal Placebo/Nocebo Responses [PDF]

The Journal of Neuroscience, 2003
The placebo and nocebo effect is believed to be mediated by both cognitive and conditioning mechanisms, although little is known about their role in different circumstances. In this study, we first analyzed the effects of opposing verbal suggestions on experimental ischemic arm pain in healthy volunteers and on motor performance in Parkinsonian ...
BENEDETTI, Fabrizio, POLLO, Antonella, LOPIANO, Leonardo, LANOTTE, Michele Maria Rosario, VIGHETTI S., RAINERO, Innocenzo   +5 more
openaire   +3 more sources

Does electromagnetic hypersensitivity originate from nocebo responses? Indications from a qualitative study [PDF]

Bioelectromagnetics, 2015
Idiopathic Environmental Intolerance attributed to Electromagnetic Fields (IEI‐EMF) is a condition in which symptoms are attributed to electromagnetic field (EMF) exposure. As electro‐hypersensitive (EHS) people have repeatedly been observed, during provocation trials, to report symptoms following perceived rather than actual exposure, the hypothesis ...
openaire   +3 more sources

Chicken or egg? Attribution hypothesis and nocebo hypothesis to explain somatization associated to perceived RF-EMF exposure

Frontiers in Public Health
IntroductionThe aim of this study is to understand the temporal relationship between the somatization usually attributed to RF-EMFs, and to evaluate the attribution hypothesis and the nocebo hypothesis in this context.MethodIn this longitudinal study ...
S. Ariccio, E. Traini, L. Portengen, A. Martens, P. Slottje, R. Vermeulen, A. Huss   +6 more
doaj   +1 more source

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

Understanding Placebo and Nocebo Responses Based on a Randomized Sham-Controlled Study on Acupuncture in Integrative Cancer Care

Integrative Cancer Therapies
Objective: Since placebo and nocebo-responses during acupuncture therapy are rarely studied in clinical contexts, the objective was to investigate placebo and nocebo-responses in a clinical context through comparing positive and negative side-effects ...
Anna Efverman BSP, PhD
doaj   +1 more source

Evidence of a Media-Induced Nocebo Response Following a Nationwide Antidepressant Drug Switch

Clinical Psychology in Europe, 2019
[Background] In 2017, patients on a generic or branded antidepressant venlafaxine were switched to a new generic formulation (Enlafax). In February and April 2018, two major NZ media outlets ran stories about the new generic being less effective ...
Kate MacKrill, Greg D. Gamble, Debbie J. Bean, Tim Cundy, Keith J. Petrie   +4 more
doaj   +1 more source

Open Pilot Trial of a Single Session Consultation Service for Clients at StrongMinds Uganda

Mental Health Science, Volume 4, Issue 3, September 2026.
ABSTRACT The need for mental health services in Sub‐Saharan Africa far exceeds the availability of support, creating long waitlists for the few services that are in place. To address this crisis, implementing evidence‐based, single‐session interventions for individuals seeking treatment may provide timely relief.
Rosco Kasujja, Ian Sotomayor, Peter Birungi, Morris Ndeezi, Erica Szkody, Jessica L. Schleider   +5 more
wiley   +1 more source

Anticipated and Actual Pain Intensity in Patients Receiving Intravitreal Injections: A Cross Sectional Study

Nursing Open, Volume 13, Issue 9, September 2026.
ABSTRACT Aim To compare patients' anticipated pain intensity and actual pain experienced during intravitreal injection. Design The study used a quantitative, cross‐sectional design. Methods A single‐centre study was conducted in a group of 115 patients. Data were collected using medical records and the Numerical Rating Scale (NRS).
Ewa Kobos, Katarzyna Leszczyńska
wiley   +1 more source

Effects of Open- and Closed-Label Nocebo and Placebo Suggestions on Itch and Itch Expectations

Frontiers in Psychiatry, 2019
Placebo and nocebo effects have been shown to influence subjective symptoms such as itch. These effects can be induced by influencing outcome expectations through, for example, combining the application of an inert substance (e.g., a cream) with verbal ...
Stefanie H. Meeuwis, Stefanie H. Meeuwis, Henriët van Middendorp, Henriët van Middendorp, Antoinette I.M. van Laarhoven, Antoinette I.M. van Laarhoven, Antoinette I.M. van Laarhoven, Dieuwke S. Veldhuijzen, Dieuwke S. Veldhuijzen, Adriana P.M. Lavrijsen, Andrea W.M. Evers, Andrea W.M. Evers, Andrea W.M. Evers   +12 more
doaj   +1 more source