Results 81 to 90 of about 3,074 (167)

Beyond concealment: Translating placebo research into migraine care

Headache: The Journal of Head and Face Pain, EarlyView.
Julian Kleine‐Borgmann, Katharina Schmidt, Ulrike Bingel   +2 more
wiley   +1 more source

Nocebo Responses in Brain Diseases: A Systematic Review of the Current Literature

, 2018
Placebo is an intervention with no therapeutic effect that is used as a control in randomized controlled trials (RCTs). Placebo effects and responses can produce a beneficial effect that cannot be attributed to the properties of the intervention itself, since it is usually inactive, and should, therefore, be due to the patient's expectations about ...
Zis, Panagiotis, Mitsikostas, Dimos-Dimitrios, Zis, Panagiotis, Mitsikostas, Dimos-Dimitrios   +3 more
openaire   +4 more sources

Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Somatosensory Amplification and Nocebo Responses

PLoS ONE, 2014
A large number of unwanted adverse events and symptoms reported by patients in clinical trials are not caused by the drug provided, since most of adverse events also occur in corresponding placebo groups. These nocebo effects also play a major role in drug discontinuation in clinical practice, negatively affecting treatment efficacy as well as patient ...
Wendt, Laura, Albring, Antje, Benson, Sven, Engler, Harald, Engler, Andrea, Hinney, Anke, Rief, Winfried, Witzke, Oliver, Schedlowski, Manfred   +8 more
openaire   +4 more sources

Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms

Scientific Reports, 2017
This study sought to test the effect of genetic information and information about the caffeine content of a beverage on caffeine withdrawal, specifically if: (1) being informed that one has tested positive for a gene related to caffeine withdrawal can ...
Llewellyn Mills, Ilan Dar-Nimrod, Ben Colagiuri   +2 more
doaj   +1 more source

Between placebo and nocebo: Response to control treatment is mediated by amygdala activity and connectivity. [PDF]

Eur J Pain, 2020
Egorova N, Benedetti F, Gollub RL, Kong J.   +3 more
europepmc   +1 more source

Placebo and nocebo responses in restless legs syndrome

, 2018
To estimate the placebo and nocebo responses in restless legs syndrome (RLS) and explore their determinants.
Silva, Maria A, Duarte, Gonçalo, Camara, Raquel, Rodrigues, Filipe Brogueira, Fernandes, Ricardo M, Abreu, Daisy, Mestre, Tiago, Costa, João, Trenkwalder, Claudia, Ferreira, Joaquim J   +9 more
openaire   +1 more source

Discontinuation of Fumaric Acid Esters is Affected by Depressive Symptomatology: A Retrospective Analysis

Acta Dermato-Venereologica
Fumaric acid esters (FAEs) remain a widespread therapy option for moderate-to-severe psoriasis. However, drug survival of FAEs is limited by adverse events (AEs) or inadequate treatment response.
Frederik Krefting, Stefanie Hölsken, Manfred Schedlowski, Wiebke Sondermann   +3 more
doaj   +1 more source

Placebo and Nocebo Responses in Pharmacological Trials of Tic Disorders: A Meta‐Analysis

Movement Disorders
AbstractBackgroundClinical trials of new drugs for tic disorders (TD) often fail to yield positive results. Placebo and nocebo responses play a vital role in interpreting the outcomes of randomized controlled trials (RCTs), yet these responses in RCTs of TD remain unexplored.ObjectiveThe aim was to assess the magnitude of placebo and nocebo responses ...
Simeng Wang, Zhiyi Xiong, Yuehua Cui, Fei Fan, Si Zhang, Ru Jia, Yuchen Hu, Liang Li, Xuan Zhang, Fei Han   +9 more
openaire   +2 more sources

Development of a personalized digital biomarker of vaccine-associated reactogenicity using wearable sensors and digital twin technology

Communications Medicine
Background Effective response to vaccination requires activation of the innate immune system, triggering the synthesis of inflammatory cytokines. The degree of subjective symptoms related to this, referred to as reactogenicity, may predict their eventual
Steven R. Steinhubl, Jadranka Sekaric, Maged Gendy, Huaijian Guo, Matthew P. Ward, Craig J. Goergen, Jennifer L. Anderson, Sarwat Amin, Damen Wilson, Eustache Paramithiotis, Stephan Wegerich   +10 more
doaj   +1 more source

Interpersonal physiological and psychological synchrony predict the social transmission of nocebo hyperalgesia between individuals

Communications Psychology
Witnessing another’s pain can heighten pain in the observer. However, research has focused on the observer’s intrapersonal experience. Here, a social transmission-chain explored the spread of socially-acquired nocebo hyperalgesia.
Rodela Mostafa, Nicolas Andrew McNair, Winston Tan, Cosette Saunders, Ben Colagiuri, Kirsten Barnes   +5 more
doaj   +1 more source