Results 71 to 80 of about 3,074 (167)
Neurogastroenterology &Motility, EarlyView.Breath test–proven malabsorption does not reliably predict symptoms. Many patients without malabsorption still develop significant symptoms. Symptoms after lactose ingestion are linked to fructose sensitivity and functional GI disorders. Validated, test‐specific symptom assessment is required to identify patients who may benefit from treatment ...
Johann Hammer, Heinz F. Hammer
wiley +1 more source
Placebo and nocebo responses in restless legs syndrome
Neurology, 2017 To estimate the placebo and nocebo responses in restless legs syndrome (RLS) and explore their determinants.Databases were searched up to October 2015. Randomized, double-blind, placebo-controlled trials of patients with RLS were included if quantitative data were extractable in the placebo arm.
Silva, Maria A. +9 more
openaire +4 more sources
A neural mechanism of direct and observational conditioning for placebo and nocebo responses [PDF]
NeuroImage, 2019 Classical theories suggest placebo analgesia and nocebo hyperalgesia are based on expectation and conditioned experience. Whereas the neural mechanism of how expectation modulates placebo and nocebo effects during pain anticipation have been extensively studied, little is known about how experience may change brain networks to produce placebo and ...
Tu, Y +7 more
openaire +3 more sources
Adverse Events of Saffron (Crocus sativus L.): Systematic Review of Current Evidence
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background Crocus sativus L., commonly known as saffron, is a widely used spice with a rich history of culinary and medicinal applications. This systematic review aims to compile human data from studies on monopreparations of C. sativus, including stigma powder and other extracts, to evaluate their safety.
Fatemeh Sadat Hasheminasab +3 more
wiley +1 more source
Analgesia da placebo, anticipazione dolorifica e i possibili correlati neurali dell'effetto nocebo
Rivista Internazionale di Filosofia e Psicologia, 2018 The nocebo effect is a psychobiological effect that occurs when a negative psychosocial context that accompanies a therapy. Since the study of pain anticipation takes into account the temporal phase of the “expectation of hyperalgesia”, and considering ...
Sara Palermo
doaj +1 more source
Journal of Advanced Nursing, Volume 82, Issue 5, Page 5348-5358, May 2026.ABSTRACT Aim To co‐design an information booklet to support adults living with a peripherally inserted central catheter (PICC) at home. Design A sequential, mixed‐method approach using Boyd's co‐design framework. Method A diverse project team led co‐design of a PICC booklet based on preferences and PICC management strategies identified through content ...
Rebecca Sharp +10 more
wiley +1 more source
Double‐Blind Placebo Challenge Confirmation of Diphenhydramine Allergy
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT Diphenhydramine, a first‐generation H1–antihistamine commonly used for allergic symptom relief and infusion premedication, rarely causes true systemic hypersensitivity. When suspected reactions are mild and subjective—particularly in anxious patients—objective confirmation is essential.
Ruchi Patel +2 more
wiley +1 more source
Can a Brief Relaxation Exercise Modulate Placebo or Nocebo Effects in a Visceral Pain Model?
Frontiers in Psychiatry, 2019 Translational research aiming to elucidate mediators and moderators of placebo and nocebo effects is highly relevant. This experimental study tested effects of a brief progressive muscle relaxation (PMR) exercise, designed to alter psychobiological ...
Sigrid Elsenbruch +3 more
doaj +1 more source
European Journal of Pain, Volume 30, Issue 4, April 2026.ABSTRACT Background Pain‐related autonomic responses are increased after experimentally‐induced secondary mechanical hyperalgesia (SMH), as well as in a variety of chronic pain cohorts. In this state of sensitization, negative expectations further amplify these enhanced responses.
Florin Allmendinger +5 more
wiley +1 more source
Classical Conditioning as a Distinct Mechanism of Placebo Effects
Frontiers in Psychiatry, 2019 Classical conditioning was suggested as a mechanism of placebo effects in the 1950s. It was then challenged by response expectancy theory, which proposed that classical conditioning is just one of the means by which expectancies are acquired and changed.
Przemysław Bąbel
doaj +1 more source