Results 51 to 60 of about 85,874 (280)

Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]

, 2010
An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier, Baron, Basbaum, Cai, Calignano, Callaghan, Caterina, Chen, Chen, Coderre, Costigan, Costigan, D. J. Anderson, De Felipe, Delmas, Dong, Gerevich, Guan, Guan, Herrero, Honan, Ikeda, Julius, Knabl, Kusudo, Lembo, Li, Li, Liu, Liu, Lu, MacDermott, MacPherson, Malmberg, Melzack, Melzack, Miraucourt, Ndong, Neumann, Q. Liu, Rau, Rodriguez Parkitna, S. N. Raja, Scholz, Seal, Woolf, X. Dong, Y. Guan, Z. Tang, Zeng   +49 more
core   +2 more sources

INDEX OF ANALGESIA-NOCICEPTION: OPPORTUNITIES AND LIMITS

Вестник анестезиологии и реаниматологии, 2017
The review includes clinical opportunities of the new technique for evaluation balance of nociception/anti-nociception with help of medication of ANI-Monitor (MetroDoloris®, France), used abroad, with the calculation of original index of analgesia ...
A. P. Spasova, G. P. Tikhova, R. O. Bazarov   +2 more
doaj   +1 more source

The validity and applications of the analgesia nociception index: a narrative review

Frontiers in Surgery, 2023
Pain refers to the subjective, unpleasant experience that is related to illness or injury. In contrast to pain, nociception refers to the physiological neural processing of noxious stimuli, such as intra-operative surgical stimuli.
Bill Hum, Alexa Christophides, Zhaosheng Jin, Murad Elias, Kamil Taneja, Sergio D. Bergese   +5 more
doaj   +1 more source

Brain oscillations differentially encode noxious stimulus intensity and pain intensity [PDF]

, 2017
Noxious stimuli induce physiological processes which commonly translate into pain. However, under certain conditions, pain intensity can substantially dissociate from stimulus intensity, e.g. during longer-lasting pain in chronic pain syndromes.
Gross, Joachim, May, Elisabeth S., Nickel, Moritz M., Ploner, Markus, Postorino, Martina, Schmidt, Paul, Ta Dinh, Son, Tiemann, Laura   +7 more
core   +1 more source

Antinociceptive activity of the S1P-receptor agonist FTY720 [PDF]

, 2008
FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist.
Angioni, Carlo Federico, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Marian, Claudiu, Pierre, Sandra, Popp, Laura, Schmidt, Helmut, Scholich, Klaus   +8 more
core   +1 more source

Stereotypical escape behavior in Caenorhabditis elegans allows quantification of nociceptive stimuli levels

, 2016
Experiments of pain with human subjects are difficult, subjective, and ethically constrained. Since the molecular mechanisms of pain transduction are reasonably conserved among different species, these problems are partially solved by the use of animal ...
Leung, Kawai, Mohammadi, Aylia, Nemenman, Ilya, Ryu, William S.   +3 more
core   +2 more sources

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD, Dickenson, AH, Foulkes, T, Gerke, V, Lane, T, Matthews, EA, Nassar, MA, Okuse, K, Wood, JN   +8 more
core   +1 more source

Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes

Cell Reports
Summary: The relationship between transcription and protein expression is complex. We identified polysome-associated RNA transcripts in the somata and central terminals of mouse sensory neurons in control, painful (plus nerve growth factor), and pain ...
M. Ali Bangash, Cankut Cubuk, Federico Iseppon, Rayan Haroun, Chloe Garcia, Ana P. Luiz, Manuel Arcangeletti, Samuel J. Gossage, Sonia Santana-Varela, James J. Cox, Myles J. Lewis, John N. Wood, Jing Zhao   +12 more
doaj   +1 more source

Mechanisms involved in the nociception triggered by the venom of the armed spider Phoneutria nigriventer.

PLoS Neglected Tropical Diseases, 2013
BackgroundThe frequency of accidental spider bites in Brazil is growing, and poisoning due to bites from the spider genus Phoneutria nigriventer is the second most frequent source of such accidents.
Camila Gewehr, Sara Marchesan Oliveira, Mateus Fortes Rossato, Gabriela Trevisan, Gerusa Duarte Dalmolin, Flávia Karine Rigo, Célio José de Castro Júnior, Marta Nascimento Cordeiro, Juliano Ferreira, Marcus V Gomez   +9 more
doaj   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core   +3 more sources