Results 51 to 59 of about 59 (59)

Status and Opportunities for Improvement in Pain Education in Europe: A European Pain Federation EFIC Multiple‐Methods Study

open access: yesEuropean Journal of Pain, Volume 29, Issue 6, July 2025.
ABSTRACT Background Pain is one of the most prevalent health issues in Europe, yet the quality of pain education for healthcare professionals remains unclear. This study assessed the status of undergraduate and postgraduate pain education for nurses, physicians, psychologists, and physiotherapists across Europe, identifying key strategies to enhance ...
Nathan Skidmore   +9 more
wiley   +1 more source

Chronic, Battery‐Free, Fully Implantable Multimodal Spinal Cord Stimulator for Pain Modulation in Small Animal Models

open access: yesAdvanced Science, Volume 12, Issue 21, June 5, 2025.
This work introduces wireless‐powered fully implantable spinal cord stimulation (SCS) in freely moving animal models, supporting diverse ethological paradigms. kHz stimulation with real‐time digital programming offers versatile, dynamically optimized therapy. Scalable fabrication ensures high N studies and seamless translation.
Allie J. Widman   +11 more
wiley   +1 more source

Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis

open access: yesArthritis &Rheumatology, Volume 77, Issue 6, Page 664-676, June 2025.
Objective Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune‐regulatory cells in pain is unknown. Our objective was to identify synovial innate immune
Holly T. Philpott   +14 more
wiley   +1 more source

⁠⁠Functional Foods Alleviate Behavioral Alterations and Improve GABAergic System Regulating TLR‐4/NF‐κB Axis in Valproic‐Induced Autism

open access: yesBrain and Behavior, Volume 15, Issue 6, June 2025.
Dietary supplementation with Coriolus versicolor ameliorate neuroinflammation VPA‐induced. ABSTRACT Scope Valproic acid (VPA) postnatal exposure in mice results in behavioral impairment, aberrant sensitivity to sensory stimuli, and self‐harming behavior, hallmarks of autism.
Francesco Molinari   +11 more
wiley   +1 more source

How Do Individually Ventilated Cages Affect the Welfare of Male BALB/c Mice? Comprehensive Assessment of Behavior, Metabolism, and Responses to Acute Painful Stimuli

open access: yesBrain and Behavior, Volume 15, Issue 6, June 2025.
IVC housing conditions cause significant changes in behavioral patterns, metabolism, and nociceptive responses in mice. ABSTRACT Introduction Housing conditions, which have a major impact on the welfare of laboratory animals, are an important issue in experimental research.
Aslı Çelik   +7 more
wiley   +1 more source

Structural Connectivity Differences Reflect Microstructural Heterogeneity of the Human Insular Cortex

open access: yesHuman Brain Mapping, Volume 46, Issue 8, June 1, 2025.
Combining the microstructural JulichBrain Atlas with tractography, we analyzed connectivity patterns within the cytoarchitecture of the human insula. We discovered six clusters, consistent across two large cohorts, with distinct connectivity patterns for different anatomical and functional target regions, reflecting fundamental principles of ...
Julian Quabs   +2 more
wiley   +1 more source

Relationship Between Lumbar Multifidus Morphometry and Pain/Disability in Individuals With Chronic Nonspecific Low Back Pain After Considering Demographics, Fear‐Avoidance Beliefs, Insomnia, and Spinal Degenerative Changes

open access: yesJOR SPINE, Volume 8, Issue 2, June 2025.
We examined the associations between fatty infiltration of the lumbar multifidus muscle and clinical outcomes (pain intensity and disability) in people with chronic nonspecific low back pain after controlling for various confounders like demographics, fear‐avoidance beliefs, insomnia, and spinal degenerative phenotypes.
Sabina M. Pinto   +7 more
wiley   +1 more source

An Extracellular Matrix Hydrogel Restores Disc Volume and Alleviates Axial Hypersensitivity in a Rat Model of Disc‐Associated Pain

open access: yesJOR SPINE, Volume 8, Issue 2, June 2025.
Degenerated painful discs present with mechanical instability, inflammation, and nerve sprouting, however, patients treated with spinal stabilizing procedures often report pain alleviation indicating spinal mechanics, could be causative in the production of pain.
David J. Lillyman   +4 more
wiley   +1 more source

High accuracy of component positioning and restoration of lower limb alignment using robotic medial unicompartmental knee arthroplasty

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, Volume 33, Issue 6, Page 1982-1991, June 2025.
Abstract Purpose Unicondylar arthroplasty was performed using robotic medial unicompartmental knee arthroplasty (R‐mUKA) and gap‐balancing instrumentation. Our hypothesis was that robotic unicondylar knee arthroplasty accurately restores component positioning and lower limb alignment when compared to preoperative planning with actual implantation ...
Emanuele Diquattro   +5 more
wiley   +1 more source

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