Results 1 to 10 of about 140,847 (256)

Non-alcoholic fatty liver disease [PDF]

BMC Medicine, 2017
Non-alcoholic fatty liver disease has emerged a major challenge because of it prevalence, difficulties in diagnosis, complex pathogenesis, and lack of approved therapies. As the burden of hepatitis C abates over the next decade, non-alcoholic fatty liver disease will become the major form of chronic liver disease in adults and children and could become
Brent A. Neuschwander-Tetri
core   +8 more sources

Non-alcoholic fatty liver disease [PDF]

Clinical Medicine, 2018
Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of about 25%. Incidence is increasing with rising levels of obesity, type 2 diabetes and the metabolic syndrome, and NAFLD is predicted to become the leading cause of cirrhosis requiring liver transplantation in the next decade.
Maurice, J, Manousou, P
openaire   +6 more sources

Non-Alcoholic Fatty Liver Disease in Children [PDF]

Medicina, 2021
Background and Objectives: The prevalence of pediatric non-alcoholic fatty liver disease is increasing. A lot of new data are published regularly. Materials and Methods: Original clinical studies, review articles, and guidelines in children were searched for and the most relevant included in this review.
Rok Orel, Rok Orel, Jernej Brecelj, Jernej Brecelj   +3 more
openaire   +5 more sources

Non alcoholic fatty liver disease

Annals of Hepatology, 2009
A 45 year old man with known hypertension, type 2 diabetes mellitus, and central obesity presents with fatigue and mild discomfort in the abdominal right upper quadrant. Repeated blood tests show a persistent alanine aminotransferase concentration of 100 IU/l (reference range 10-50) and a γ glutamyl transferase concentration of 80 IU/l (range 10-50 ...
Tim Usherwood, Jacob George, Neeraj Bhala   +2 more
  +10 more sources

Non-alcoholic fatty liver disease [PDF]

Clinical Medicine, 2020
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD is defined by excess fat in the liver and has a multidirectional relationship with metabolic syndrome. The prevalence of NAFLD has risen rapidly in recent years in line with the obesity epidemic and associated increases in type 2 diabetes ...
William Alazawi, Wenhao Li
openaire   +3 more sources

Platelets in Non-alcoholic Fatty Liver Disease [PDF]

Frontiers in Pharmacology, 2022
Non alcoholic steatohepatitis (NASH) is the inflammatory reaction of the liver to excessive accumulation of lipids in the hepatocytes. NASH can progress to cirrhosis and hepatocellular carcinoma (HCC). Fatty liver is the hepatic manifestation of metabolic syndrome.
Andrea Dalbeni, Andrea Dalbeni, Marco Castelli, Mirko Zoncapè, Mirko Zoncapè, Pietro Minuz, David Sacerdoti   +6 more
openaire   +3 more sources

Pathophysiology of Non Alcoholic Fatty Liver Disease [PDF]

International Journal of Molecular Sciences, 2016
The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating ...
Salvatore Petta, Amalia Gastaldelli, Eleni Rebelos, Elisabetta Bugianesi, Piergiorgio Messa, Luca Miele, Gianluca Svegliati-Baroni, Luca Valenti, Ferruccio Bonino   +8 more
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Endotoxins and Non-Alcoholic Fatty Liver Disease [PDF]

Frontiers in Endocrinology, 2021
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. It occurs with a prevalence of up to 25%, of which 10–20% cases progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. The histopathology of NASH is characterized by neutrophilic infiltration, and endotoxins from gram-negative rods have ...
Takaomi Kessoku, Takaomi Kessoku, Takashi Kobayashi, Kento Imajo, Kosuke Tanaka, Kosuke Tanaka, Atsushi Yamamoto, Kota Takahashi, Yuki Kasai, Anna Ozaki, Michihiro Iwaki, Michihiro Iwaki, Asako Nogami, Yasushi Honda, Yuji Ogawa, Shingo Kato, Takuma Higurashi, Kunihiro Hosono, Masato Yoneda, Takayuki Okamoto, Haruki Usuda, Koichiro Wada, Noritoshi Kobayashi, Noritoshi Kobayashi, Satoru Saito, Atsushi Nakajima   +25 more
openaire   +3 more sources

Management of non-alcoholic fatty liver disease [PDF]

BMJ, 2021
ABSTRACT Non-alcoholic fatty liver disease is a very common medical condition, driven by a combination of genetic and lifestyle factors, ultimately producing a severe chronic liver disease and increased cardiovascular risk. Most people are asymptomatic for a long time, and their daily life is unaffected, leading to difficulty in identifying ...
Petroni, Maria Letizia, Brodosi, Lucia, Bugianesi, Elisabetta, Marchesini, Giulio   +3 more
openaire   +4 more sources

Mitochondria in non-alcoholic fatty liver disease [PDF]

The International Journal of Biochemistry & Cell Biology, 2018
NAFLD is a common disease in Western society and ranges from steatosis to steatohepatitis and to end-stage liver disease. The molecular mechanisms that cause the progression of steatosis to severe liver damage are not fully understood. One suggested mechanism involves the oxidation of biomolecules by mitochondrial ROS which initiates a vicious cycle of
Simões, Inês C. M., Fontes, Adriana, Pinton, Paolo, Zischka, Hans, Wieckowski, Mariusz R.   +4 more
openaire   +4 more sources