Results 111 to 120 of about 15,618,429 (289)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Estimation of Floor Response Spectra for Risk- Targeted Seismic Design of Non-Structural Elements

open access: yes
The seismic performance of buildings is heavily influenced by the seismic performance of nonstructural elements. Seismic damage to non-structural elements can significantly contribute to economic losses, loss of functionality, and loss of life ...
Gentile, Roberto   +2 more
core   +1 more source

Effect of essential and non-essential elements on cellular immune system of cotton bollworm, Helicoverpa armigera Hübner (Lepidoptera: Noctuidae)

open access: yesInvertebrate Survival Journal, 2018
Three concentrations of 12.5, 25 and 50 mg/kg of cadmium and 25, 50 and 100 mg/kg of copper were added to artificial diet and fed to larvae for 7 days. Total hemocytes count (THC) at 12.5 mg/kg concentration of cadmium significantly declined, but at 50 ...
A Baghban, J J Sendi, A Zibaee
doaj  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Essential and non-essential element concentrations in human milk samples and the assessment of infants’ exposure

open access: yesScientific Reports
AbstractAs the data concerning element concentrations in human milk (HM) samples and their intake by infants are lacking in Poland, the present study aimed to explore this issue. The material consisted of HM samples obtained from 30 exclusively breastfeeding mothers during 4–6 weeks postpartum. Additionally, to identify the factors that may potentially
Agnieszka Bzikowska-Jura   +7 more
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A comprehensive review on epidemiology, health effects, and trace element interaction with relevance to arsenic toxicity

open access: yesDiscover Environment
Trace elements are chemical elements required in small quantities for normal physiological and biochemical functions in biological systems. These elements are grouped as essential (Fe, Zn, Cu, Mn etc.) and non-essential elements (Al, As, Pb, Hg etc ...
Nazish Mazhar Ali   +2 more
doaj   +1 more source

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