Results 111 to 120 of about 771,313 (279)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

EXPLORATORY HEALTH RISK ASSESSMENT OF ESSENTIAL AND NON- ESSENTIAL TRACE ELEMENTS IN CAGE-CULTURED FISH SPECIES FROM BADAGRY LAGOON, NIGERIA

Food and Environment Safety
Fish readily accumulate trace elements from water, sediments, and feed, making them potential vectors of human exposure. This study assessed the concentrations, estimated daily intake (EDI), and potential health risks of essential and non-essential trace
Oluwadamilola Ruth AJIBOYE
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Bioremediation of Non-Essential Toxic Elements Using Indigenous Microbes in Soil Following Irrigation with Treated Wastewater

Applied Sciences
Treated wastewater (TWW) is recognised as an alternative irrigation source to mitigate global water scarcity for irrigation purposes. However, one of the challenges of using TWW as an irrigation source is the accumulation of non-essential toxic elements ...
Itumeleng Kgobokanang Jacob Kekana, Pholosho Mmateko Kgopa, Lawrence Munjonji   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Investigating the Interplay of Toxic Metals and Essential Elements in Cardiovascular Disease

Journal of Xenobiotics
Cardiovascular diseases (CVDs) are the leading cause of mortality globally, accounting for approximately one-third of all deaths. Exposure to toxic metals poses significant risks to cardiovascular health, contributing to the development of CVDs ...
Aderonke Gbemi Adetunji, Emmanuel Obeng-Gyasi   +1 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Mixture effects of trace element levels on cardiovascular diseases and type 2 diabetes risk in adults using G-computation analysis

Scientific Reports
There is an increasing concern about the health effects of exposure to a mixture of pollutants. This study aimed to evaluate the associations between serum levels of heavy/essential metals ([Arsenic (As), Cadmium (Cd), Mercury (Hg), Lead (Pb), Nickel (Ni)
Borhan Mansouri, Ayoob Rezaei, Kiomars Sharafi, Nammamali Azadi, Meghdad Pirsaheb, Maryam Rezaei, Samaneh Nakhaee   +6 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Biodiminution of lithium in forest floor food webs

Scientific Reports
Lithium (Li) is an emerging contaminant of global concern due to its rapidly increasing demand for rechargeable batteries. However, concerns exist regarding its bioaccumulation and trophic transfer in natural food webs, with extremely scarce data ...
Norah Muisa, Matthew Long-Hei Cheng, Martin Tsz-Ki Tsui   +2 more
doaj   +1 more source