Results 201 to 210 of about 341,882 (288)

Airborne PM₁₀ Decreases Ku80 Expression and Ku70-Ku80 Heterodimer Levels of the Non-Homologous End Joining Repair Pathway in Lung Epithelial Cells. [PDF]

Int J Mol Sci
Quezada-Maldonado EM, Lozolla-Ortiz JI, Santibáñez-Andrade M, Morales-Bárcenas R, García-Cuellar CM, Sánchez-Pérez Y.   +5 more
europepmc   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Conversion of Ku80 K568 crotonylation to SUMOylation facilitates DNA non-homologous end joining and cancer radioresistance. [PDF]

Signal Transduct Target Ther
Zhao H, Gao S, Han Y, Xie D, Xuan L, Huang X, Luo J, Ran Q, Li G, Guo H, Hu W, Jia J, Liu X, Liu Y, Tan J, Bai C, Gu Y, Ma T, Li Z, Guan H, Huang R, Zhou PK.   +21 more
europepmc   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Single-molecule techniques in studying the molecular mechanisms of DNA synapsis in non-homologous end-joining repair. [PDF]

Biophys Rep
Jiang Y, Zhao C, Zhang C, Li W, Liu D, Zhao B.   +5 more
europepmc   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells. [PDF]

Nat Commun
Mikhova M, Goff NJ, Janovič T, Heyza JR, Meek K, Schmidt JC.   +5 more
europepmc   +1 more source

Fish Scales: A Multifunctional Biomaterial from Nature

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Fish scales demonstrate nature's solution to impact protection through overlapping multilayered architecture. This biological design combines mineralized surfaces with collagen networks to achieve both flexibility and fracture resistance. The structural principles inspire advanced protective materials and biomedical implants, where damage tolerance ...
Liyao Dong, Xiaojie Sun, Xiguang Chen
wiley   +1 more source

ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin.

Cell Rep
Simões-Sousa S, Amin N, Lane KA, Harrod A, Pedersen M, Pardo M, Rasetti-Escargueil C, Kozik Z, Begg KAG, Ribeiro A, Banerjee S, Stucki M, Harrington KJ, Choudhary JS, Downs JA.   +14 more
europepmc   +1 more source