Results 71 to 80 of about 341,882 (288)
PLoS Pathogens, 2022 Beta human papillomavirus (β-HPV) are hypothesized to make DNA damage more mutagenic and potentially more carcinogenic. Double strand breaks (DSBs) are the most deleterious DNA lesion.
Changkun Hu +4 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova +4 more
wiley +1 more source
Crop JournalChromosomal DNA double-strand breaks (DSBs) are often generated in the genome of all living organisms. To combat DNA damage, organisms have evolved several DSB repair mechanisms, with nonhomologous end-joining (NHEJ) and homologous recombination (HR ...
Shuanghui Zhao +7 more
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A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
Nature Communications, 2016 A DNA double strand break can be repaired through either the non-homologous end-joining or the homologous recombination pathways. Here the authors conduct a genome-wide screen and identify a role for CCAR2 in pathway choice by regulating DNA end ...
Ana López-Saavedra +8 more
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Change of gene structure and function by non-homologous end-joining, homologous recombination, and transposition of DNA. [PDF]
PLoS Genetics, 2009 An important objective in genome research is to relate genome structure to gene function. Sequence comparisons among orthologous and paralogous genes and their allelic variants can reveal sequences of functional significance.
Wolfgang Goettel, Joachim Messing
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Artemis over-expression and radiosensitivity in human cell lines [PDF]
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The cellular radiosensitivity of two fibroblast cell lines derived from a breast cancer patient that “over-reacted” to radiotherapy (84BR) and a patient ...
Ulus-Senguloglu, Gonul
core
Advanced Materials, EarlyView.This review summarizes the principles and challenges of nonaqueous lithium‐oxygen batteries and recent advances in cathode catalysts, including carbon‐based materials, metals, oxides, sulfides, nitrides, carbides, and redox mediators. It highlights emerging design strategies and artificial intelligence‐driven approaches, emphasizing data‐assisted ...
Yuqing Yao +8 more
wiley +1 more source
Ancient and recent adaptive evolution of primate non-homologous end joining genes.
PLoS Genetics, 2010 In human cells, DNA double-strand breaks are repaired primarily by the non-homologous end joining (NHEJ) pathway. Given their critical nature, we expected NHEJ proteins to be evolutionarily conserved, with relatively little sequence change over time ...
Ann Demogines +6 more
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Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Potential Roles of the Retinoblastoma Protein in Regulating Genome Editing
Frontiers in Cell and Developmental Biology, 2018 Genome editing is an important tool for modifying genomic DNA through introducing DNA insertion or deletion at specific locations of a genome. Recently CRISPR/Cas9 has been widely employed to improve the efficiency of genome editing.
Yuning Jiang, Wai Kit Chu
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