Results 81 to 90 of about 341,882 (288)

Dramatic Changes in the Ratio of Homologous Recombination to Nonhomologous DNA-End Joining in Oocytes and Early Embryos ofXenopus laevis

, 1996
We have developed a versatile plasmid vector (pReco-sigma) for recombination studies. When linearized and introduced into the cells of interest, pReco-sigma allows the simultaneous determination of the relative frequencies of homologous recombination ...
Adlkofer, Katrin, Georgiev, Oleg, Duri Rungger, Rémy Bruggmann, Bruggmann, Rémy, Oleg Georgiev, Hagmann, M, Georgiev, O, Schaffner, W, Rungger, Duri, Rungger, D, Walter Schaffner, Michael Hagmann, Adlkofer, K, Schaffner, Walter, Pfeiffer, P, Katrin Adlkofer, Pfeiffer, Petra, Petra Pfeiffer, Hagmann, Michael   +19 more
core   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Current advances in the role of classical non‐homologous end joining in hematologic malignancies

Clinical and Translational Discovery
Background Double‐strand breaks (DSBs) are universally acknowledged as the most detrimental type of DNA damage, and their effective repair primarily depends on the non‐homologous end joining (NHEJ) pathway.
Pengcheng Liu, Zizhen Xu
doaj   +1 more source

The checkpoint clamp protein Rad9 facilitates DNA-end resection and prevents alternative non-homologous end joining

, 2015
DNA damage activates the cell cycle checkpoint to regulate cell cycle progression. The checkpoint clamp (Rad9-Hus1-Rad1 complex) is recruited to damage sites, and is required for checkpoint activation.
Feng-Ling Tsai (660867), Mihoko Kai (660868)   +1 more
core   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Stitching up broken DNA ends by FANCA

Molecular & Cellular Oncology, 2018
RAD52 rejoins resected broken DNA ends by mediating single-strand annealing. Our recent work elucidates that FANCA, a Fanconi anemia protein, also directly repairs double-strand breaks (DSBs) by catalyzing annealing of single-stranded DNA.
Anna Palovcak, Wenjun Liu, Fenghua Yuan, Yanbin Zhang   +3 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

WRN regulates pathway choice between classical and alternative non-homologous end joining

Nature Communications, 2016
Werner Syndrome is an accelerated aging disorder marked by genome instability, large deletions and telomere fusions, hallmarks of aberrant DNA repair.
Raghavendra A. Shamanna, Huiming Lu, Jessica K. de Freitas, Jane Tian, Deborah L. Croteau, Vilhelm A. Bohr   +5 more
doaj   +1 more source

Pholidota‐Inspired Electronic Skin Possessing Terahertz‐Wave Reflection–Absorption–Transmission Switchability

Advanced Science, EarlyView.
The pholidota‐inspired electronic skin is successfully constructed, originally realized four‐state reversible switching of terahertz‐wave reflection, absorption, transmission, and secondary reflection. In response to external demands, it issues deformation instructions, verifies the deformation state after the equipment executes the action, and thus ...
Shangjing Li, Jiangsong Hou, Yifeng Ruan, Jiang Du, Jun Qiu   +4 more
wiley   +1 more source

Double-Strand Break Repair by Non-homologous End-Joining [PDF]

, 2002
Non-homologous end-joining (NHEJ) is an important mechanism of double-strand break repair (DSBR) which is largely conserved from yeast to humans. Mammalian NHEJ is dependent on the Ku, DNA-PKcs, XRCC4 and DNA ligase IV proteins.
Chappell, Claire Joanna
core