Results 41 to 50 of about 10,385,388 (284)

Heterochiral coupling in non-ribosomal peptide macrolactamization [PDF]

Nature Catalysis, 2020
Heterochiral coupling is favoured in abiotic peptide bond formation, whereas biotic peptide bond formation is dominated by homochiral coupling. Here, we report that heterochiral coupling is a rather general paradigm in the head-to-tail macrolactamization of non-ribosomal peptide biosynthesis. The canonical cis-acting offloading cyclases, such as type I
Kenichi Matsuda, Rui Zhai, Takahiro Mori, Masakazu Kobayashi, Ayae Sano, Ikuro Abe, Toshiyuki Wakimoto   +6 more
openaire   +2 more sources

Streptococcus pneumoniae Proteins AmiA, AliA, and AliB Bind Peptides Found in Ribosomal Proteins of Other Bacterial Species [PDF]

, 2018
The nasopharynx is frequently colonized by both commensal and pathogenic bacteria including Streptococcus pneumoniae (pneumococcus). Pneumococcus is an important pathogen responsible for bacterial meningitis and community acquired pneumonia but is also ...
Hathaway, Lucy J, Lucy J. Hathaway, Hathaway, Lucy Jane, Fauzy Nasher, Nasher, Fauzy Negiub Ali, Nasher, Fauzy, Manfred Heller, Heller, Manfred   +7 more
core   +2 more sources

Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)

Frontiers in Chemistry, 2017
Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large and diverse family of natural products. They possess interesting biological properties such as antibiotic or anticancer activities, making them attractive for ...
Alhosna Benjdia, Clémence Balty, Olivier Berteau   +2 more
doaj   +1 more source

Toxic oligopeptides in the cyanobacterium Planktothrix agardhii-dominated blooms and their effects on duckweed (Lemnaceae) development

Knowledge and Management of Aquatic Ecosystems, 2018
Cyanobacterial toxins are a global threat to aquatic organisms; however, they represent only one group of bioactive cyanobacterial metabolites. Very little is known about the effects of other cyanobacterial products (e.g., non-ribosomal oligopeptides) on
Pawlik-Skowrońska Barbara, Toporowska Magdalena, Mazur-Marzec Hanna   +2 more
doaj   +1 more source

Compilation of the Antimicrobial Compounds Produced by Burkholderia Sensu Stricto

Molecules, 2023
Due to the increase in multidrug-resistant microorganisms, the investigation of novel or more efficient antimicrobial compounds is essential. The World Health Organization issued a list of priority multidrug-resistant bacteria whose eradication will ...
Mariana Rodríguez-Cisneros, Leslie Mariana Morales-Ruíz, Anuar Salazar-Gómez, Fernando Uriel Rojas-Rojas, Paulina Estrada-de los Santos   +4 more
doaj   +1 more source

An HflX-type GTPase from Sulfolobus solfataricus binds to the 50S ribosomal subunit in all nucleotide-bound states [PDF]

, 2011
HflX GTPases are found in all three domains of life, Bacteria, Archaea, and Eukaryotes. HflX from Escherichia coli has been shown to bind to the 50S ribosomal subunit in a nucleotide-dependent manner and this interaction strongly stimulates its GTPase ...
Fabian Blombach, J. Van Der Oost, Daan C. Swarts, John van der Oost, Londei, P., LONDEI, Paola, Christodoulou, John, John Christodoulou, Dario Benelli, D. c. Swarts, Lisa D. Cabrita, Launay, H., BENELLI, DARIO, H. Launay, Benelli, D., L. d. Cabrita, Violeta Zorraquino, Zorraquino, V., Cabrita, L.D., V. Zorraquino, Oost, J., van der, F. Blombach, J. Christodoulou, Helene Launay, Paola Londei, van der Oost, J., Blombach, F., Swarts, D.C.   +27 more
core   +1 more source

Endogenous cross-talk of fungal metabolites.

Frontiers in Microbiology, 2015
Non-ribosomal peptide synthesis in fungi requires a ready supply of proteogenic and non-proteogenic amino acids which are subsequently incorporated into the nascent non-ribosomal peptide via a thiotemplate mechanism catalysed by non-ribosomal peptide ...
Kevin J Sheridan, Stephen K Dolan, Sean eDoyle   +2 more
doaj   +1 more source

Pepticinnamins N, O and P, cytotoxic non-ribosomal peptides from a Soil-Derived Streptomyces mirabilis P8-A2 [PDF]

Cinnamoyl moiety containing non-ribosomal peptides represented by pepticinnamin E, are a growing family of natural products isolated from different Streptomyces and possess diverse bioactivities.
Manar, Mahmoud, Ling, Ding, Charlotte H. , Gotfredsen, Luciano D. O. , Souza, Maria Mahmoud, Abboud, Matiss, Maleckis, Tilmann, Weber, José M. A. , Moreira   +7 more
core   +1 more source

Chemical, Bioactivity, and Biosynthetic Screening of Epiphytic Fungus Zasmidium pseudotsugae

Molecules, 2020
We report the first secondary metabolite, 8,8′-bijuglone, obtained from pure cultures of the slow growing Douglas fir- (Pseudotsuga menziesii var. menziesii) foliage-associated fungus Zasmidium pseudotsugae.
Gisela A. González-Montiel, Elizabeth N. Kaweesa, Nicolas Feau, Richard C. Hamelin, Jeffrey K. Stone, Sandra Loesgen   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source