Results 31 to 40 of about 10,385,388 (284)

New Peptides Isolated from Lyngbya Species: A Review

Marine Drugs, 2010
Cyanobacteria of the genusLyngbya have proven to be prodigious producers of secondary metabolites. Many of these compounds are bioactive and show potential for therapeutic use.
Li Liu, Kathleen S. Rein
doaj   +1 more source

Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining

Nature Communications, 2018
Microbial genomes encode enzymes for biosynthesis of many uncharacterized peptides. Here, the authors screen over 7,300 bacterial genomes for potential biosynthesis of cationic non-ribosomal peptides, and identify two novel peptides with activities ...
Yong-Xin Li, Zheng Zhong, Wei-Peng Zhang, Pei-Yuan Qian   +3 more
doaj   +1 more source

Engineering the biosynthesis of non-ribosomal peptides [PDF]

, 2019
Non-ribosomal peptides are a class of natural product that exhibit diverse properties and function as toxins, antibiotics, siderophores, and pigments. Their range of activity means they have roles in medicine, agriculture and bioremediation.
Jonathan Calcott, Mark, Ackerley, David
core   +1 more source

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Nature Communications, 2018
Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity.
Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Ikuro Abe   +10 more
doaj   +1 more source

Bioactive Metabolites Produced by Cyanobacteria for Growth Adaptation and Their Pharmacological Properties

Biology, 2021
Cyanobacteria are the most abundant oxygenic photosynthetic organisms inhabiting various ecosystems on earth. As with all other photosynthetic organisms, cyanobacteria release oxygen as a byproduct during photosynthesis.
Pavitra Nandagopal, Anthony Nyangson Steven, Liong-Wai Chan, Zaidah Rahmat, Haryati Jamaluddin, Nur Izzati Mohd Noh   +5 more
doaj   +1 more source

Delftibactin-A, a Non-ribosomal Peptide With Broad Antimicrobial Activity [PDF]

Frontiers in Microbiology, 2019
The rapid emergence of drug resistant bacteria is occurring worldwide, outpacing the development of new antibiotics. It is known that some of the main sources of antibiotics are the bacteria themselves, many of which are secondary metabolites of Gram positive bacteria.
Noa Tejman-Yarden, Noa Tejman-Yarden, Ari Robinson, Yaakov Davidov, Alexander Shulman, Alexander Varvak, Fernando Reyes, Galia Rahav, Galia Rahav, Israel Nissan, Israel Nissan   +10 more
openaire   +4 more sources

Revisiting the role of cyanobacteria-derived metabolites as antimicrobial agent: A 21st century perspective

Frontiers in Microbiology, 2022
Cyanobacterial species are ancient photodiazotrophs prevalent in freshwater bodies and a natural reservoir of many metabolites (low to high molecular weight) such as non-ribosomal peptides, polyketides, ribosomal peptides, alkaloids, cyanotoxins, and ...
Joyeeta Kar, Devde Pandurang Ramrao, Ruth Zomuansangi, C. Lalbiaktluangi, Shiv Mohan Singh, Naveen Chandra Joshi, Ajay Kumar, Kaushalendra, Suryakant Mehta, Mukesh Kumar Yadav, Prashant Kumar Singh   +10 more
doaj   +1 more source

KnotInFrame: prediction of –1 ribosomal frameshift events [PDF]

, 2008
Theis C, Reeder J, Giegerich R. KnotInFrame: prediction of –1 ribosomal frameshift events. Nucleic Acids Research. 2008;36(18):6013-6020.Programmed –1 ribosomal frameshift (–1 PRF) allows for alternative reading frames within one mRNA.
Corinna Theis, Theis, Corinna, Jens Reeder, Robert Giegerich, Reeder, Jens, Giegerich, Robert   +5 more
core   +1 more source

Analysis of Nucleolar Protein Dynamics Reveals the Nuclear Degradation of Ribosomal Proteins [PDF]

, 2007
Background: The nucleolus is a subnuclear organelle in which rRNAs are transcribed, processed, and assembled with ribosomal proteins into ribosome subunits.
Lamond, Angus I., Lam, Yun Wah, Andersen, J.S., Mann, M., Lamond, Angus I, Andersen, Jens S., Andersen, J., Lamond, Angus I.; id_orcid, Lamond, A.I., Mann, Matthias, Lam, Y.W., Lamond, A., Andersen, Jens S; id_orcid, Lam, Y.   +13 more
core   +1 more source

Diversity of Peptides Produced by Nodularia spumigena from Various Geographical Regions

Marine Drugs, 2012
Cyanobacteria produce a great variety of non-ribosomal peptides. Among these compounds, both acute toxins and potential drug candidates have been reported. The profile of the peptides, as a stable and specific feature of an individual strain, can be used
Lisa Spoof, Reyhan Akcaalan, Agata Blaszczyk, Monika J. Kaczkowska, Hanna Mazur-Marzec, Jussi Meriluoto   +5 more
doaj   +1 more source