Results 21 to 30 of about 10,385,388 (284)

Type S Non‐Ribosomal Peptide Synthetases for the Rapid Generation of Tailormade Peptide Libraries** [PDF]

Chemistry – A European Journal, 2022
AbstractBacterial natural products in general, and non‐ribosomally synthesized peptides in particular, are structurally diverse and provide us with a broad range of pharmaceutically relevant bioactivities. Yet, traditional natural product research suffers from rediscovering the same scaffolds and has been stigmatized as inefficient, time‐, labour‐ and ...
Nadya Abbood, Tien Duy Vo, Jonas Watzel, Kenan A. J. Bozhueyuek, Helge B. Bode   +4 more
openaire   +3 more sources

Natural product biosynthesis in bacteria associated with marine organisms [PDF]

Records of Pharmaceutical & Biomedical Sciences, 2023
Because antibiotics are becoming less effective and there is an increase in the number of cases of cancer, it is critical that researchers continue their search for novel natural antimicrobials and anti-cancer medicines.
Esraa Elsaeed, shymaa Enany, Samar Solyman, Mohamed Shohayeba, Amro Hanora   +4 more
doaj   +1 more source

The Desotamide Family of Antibiotics

Antibiotics, 2020
Microbial natural products underpin the majority of antimicrobial compounds in clinical use and the discovery of new effective antibacterial treatments is urgently required to combat growing antimicrobial resistance.
Asif Fazal, Michael E. Webb, Ryan F. Seipke   +2 more
doaj   +1 more source

Micropeptides translated from putative long non-coding RNAs

Acta Biochimica et Biophysica Sinica, 2022
Long non-coding RNAs (lncRNAs) transcribed in mammals and eukaryotes were thought to have no protein coding capability. However, recent studies have suggested that plenty of lncRNAs are mis-annotated and virtually contain coding sequences which are ...
Li Junhong, Qu Lei, Sang Lingjie, Wu Xinyu, Jiang Anlan, Liu Jian, Lin Aifu   +6 more
doaj   +1 more source

One Pathway, Two Cyclic Non-Ribosomal Pentapeptides: Heterologous Expression of BE-18257 Antibiotics and Pentaminomycins from Streptomyces cacaoi CA-170360

Microorganisms, 2021
The strain Streptomyces cacaoi CA-170360 produces the cyclic pentapeptides pentaminomycins A–H and BE-18257 A–C, two families of cyclopeptides synthesized by two non-ribosomal peptide synthetases encoded in tandem within the same biosynthetic gene ...
Fernando Román-Hurtado, Marina Sánchez-Hidalgo, Jesús Martín, Francisco Javier Ortiz-López, Daniel Carretero-Molina, Fernando Reyes, Olga Genilloud   +6 more
doaj   +1 more source

2A peptides provide distinct solutions to driving stop-carry on translational recoding [PDF]

, 2011
Funded by the U.K. Biotechnology and Biological Sciences Research Council (BB/E/01070911)Expression of viral proteins frequently includes non-canonical decoding events (‘recoding’) during translation. ‘2A’ oligopeptides drive one such event, termed ‘stop-
Yan, F, Doronina, V, Jeremy D. Brown, Fu Yan, Ryan, Martin D, Brown, Jeremy D, Escuin-Ordinas, Helena, Martin D. Ryan, Doronina, Victoria A, Ryan, Martin Denis, Sharma, Pamila, Sharma, P, Brown, Jeremy, Yan, Fu, Helena Escuin-Ordinas, Pamila Sharma, Victoria A. Doronina   +16 more
core   +1 more source

Anabaenopeptins: What We Know So Far

Toxins, 2021
Cyanobacteria are microorganisms with photosynthetic mechanisms capable of colonizing several distinct environments worldwide. They can produce a vast spectrum of bioactive compounds with different properties, resulting in an improved adaptative capacity.
Patrick Romano Monteiro, Samuel Cavalcante do Amaral, Andrei Santos Siqueira, Luciana Pereira Xavier, Agenor Valadares Santos   +4 more
doaj   +1 more source

SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center [PDF]

, 2011
As nascent polypeptide chains are synthesized, they pass through a tunnel in the large ribosomal subunit. Interaction between specific nascent chains and the ribosomal tunnel is used to induce translational stalling for the regulation of gene expression.
Roland Beckmann, Daniel N. Wilson, Wilson, D., Wilson Daniel N., Mielke Thorsten, Jens Frauenfeld, Thorsten Mielke, Berninghausen, O., Mielke, T., Hoffmann, T., Beckmann, R., Wilson, Daniel N, Frauenfeld, Jens, Seidelt, B., Birgit Seidelt, Berninghausen, Otto, Berninghausen Otto, Frauenfeld Jens, Bhushan, S., Mielke, Thorsten, Shashi Bhushan, Hoffmann Thomas, Seidelt, Birgit, Bhushan, Shashi, Hoffmann, Thomas, Thomas Hoffmann, Otto Berninghausen, Beckmann, Roland, Seidelt Birgit, Beckmann Roland, Daniel N Wilson, Frauenfeld, J., Bhushan Shashi   +32 more
core   +2 more sources

MarkCalcott/metagenomic-domain: Metagenomic domain substitution for the high-throughput modification of non-ribosomal peptides

, 2023
<p>This code was generated as part of the paper titled: Metagenomic domain substitution for the high-throughput modification of non-ribosomal peptides</p ...
MarkCalcott
core   +1 more source

Transient Domain Interactions in Non-Ribosomal Peptide Synthetases [PDF]

Biophysical Journal, 2011
Non-ribosomal peptide synthetases (NRPSs) are multi-module, multi-domain enzymes, synthesizing a wealth of important natural products in bacteria and fungi. These products often find pharmaceutical applications as antibiotics, antitumor agents or immunosuppressant drugs.
Frueh, Dominique P., Nichols, Scott, Mishra, Subrata, Arthanari, Haribabu, Koglin, Alexander, Walsh, Christopher T., Wagner, Gerhard   +6 more
openaire   +1 more source