Results 1 to 10 of about 10,385,388 (284)
Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications [PDF]
Frontiers in Chemistry, 2015 Bioorthogonal chemistry has recently emerged to be one of the most powerful tools in drug discovery and chemical biology. The exploration of it has successfully advanced the field of natural product research.
Wenjun Zhang, Xuejun Zhu
exaly +6 more sources
Efficient rational modification of non-ribosomal peptides by adenylation domain substitution [PDF]
Nature Communications, 2020 Non-ribosomal peptide synthases are multimodular enzymes comprised of adenylation (A), condensation (C) and thiolation domains. Here, the authors show that non-ribosomal peptides can be generated solely by A domain substitutions, providing evidence that ...
Mark J. Calcott +2 more
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Antibiotics, 2023 Anti-microbial peptides provide a powerful toolkit for combating multidrug resistance. Combating eukaryotic pathogens is complicated because the intracellular drug targets in the eukaryotic pathogen are frequently homologs of cellular structures of vital
András Fodor +15 more
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Diversity of Linear Non-Ribosomal Peptide in Biocontrol Fungi [PDF]
Journal of Fungi, 2020 Biocontrol fungi (BFs) play a key role in regulation of pest populations. BFs produce multiple non-ribosomal peptides (NRPs) and other secondary metabolites that interact with pests, plants and microorganisms. NRPs—including linear and cyclic peptides (L-
Xiaoyan Niu, Narit Thaochan, Qiongbo Hu
doaj +3 more sources
The Potential of Non-Ribosomal Peptide Engineering for Creating New Antimicrobial Complexes [PDF]
MoleculesSelf-assembling antimicrobial complexes are a promising new technology for the development of antimicrobial, antifungal, and other bioactive agents with targeted delivery, adaptability, and the regulation of processes over time.
Evgeniya V. Prazdnova +2 more
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In silico molecular docking of SARS-CoV-2 surface proteins with microbial non-ribosomal peptides: identification of potential drugs [PDF]
Journal of Proteins and Proteomics, 2021 Poonam Bansal +2 more
exaly +2 more sources
The Pharmacological Potential of Non-ribosomal Peptides from Marine Sponge and Tunicates [PDF]
Frontiers in Pharmacology, 2016 Sunilkumar Deshmukh +2 more
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Biosynthetic Strategies for Macrocyclic Peptides
Molecules, 2021 Macrocyclic peptides are predominantly peptide structures bearing one or more rings and spanning multiple amino acid residues. Macrocyclization has become a common approach for improving the pharmacological properties and bioactivity of peptides.
Wei Wang, S. Cyrus Khojasteh, Dian Su
doaj +1 more source
The Cell Surface, 2022 Burkholderia sensu lato bacteria have genomes rich in biosynthetic gene clusters (BGCs) encoding for multiple bioactive specialised metabolites. Diverse classes of antimicrobial natural products have been isolated from Burkholderia, including polyynes ...
Yoana D. Petrova +1 more
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Frontiers in Microbiology, 2021 The genome sequencing and mining of microorganisms from unexplored and extreme environments has become important in the process of identifying novel biosynthetic pathways. In the present study, the biosynthetic potential of Paenibacillus sp.
Jolanta Lebedeva +5 more
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