Systematic Review of the Huntington's Disease Drug Development Pipeline, 2014 to 2025
Abstract Background In the past decade, significant advances have improved our understanding of the mechanisms underlying HD pathobiology leading to several putative therapeutic targets for HD. Objective The aim was to describe the Huntington's disease (HD) drug development clinical pipeline.
Pavlina Konstantinova +5 more
wiley +1 more source
Apple Pomace Fermented with Non-<i>Saccharomyces</i> Yeast as a Factor Modulating Gut Microbiota. [PDF]
Liszkowska-Walisiak W +8 more
europepmc +1 more source
ABSTRACT The tRNA splicing endonuclease (TSEN) removes introns from precursor tRNAs (pre‐tRNAs) in eukaryotes and archaea, but the architecture and subunit organization of plant TSEN remain poorly defined. Here, we integrated in planta bimolecular fluorescence complementation (BiFC) assays with AlphaFold3 (AF3)‐based structural modeling, molecular ...
Mohammad Moniruzzaman +2 more
wiley +1 more source
Effects of Mixed Fermentation with Indigenous Xinjiang Non-<i>Saccharomyces</i> Yeasts and <i>Saccharomyces cerevisiae</i> on Co-Fermentation Characteristics and the Quality of Munage Wine. [PDF]
Deng Y +9 more
europepmc +1 more source
Saccharomyces & non-Saccharomyces yeasts with probiotic potential
Hoy en día, el papel que juega la microbiota intestinal en la salud es un aspecto de gran interés. Uno de los enfoques actuales más utilizados en la modulación de su equilibrio se basa en la administración de probióticos. El trabajo realizado en la presente Tesis Doctoral ha consistido en la selección de levaduras con potencial probiótico mediante un ...
openaire +1 more source
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier +15 more
wiley +1 more source
Chemical Composition and Flavor Characteristics of Cider Fermented with Saccharomyces cerevisiae and Non-Saccharomyces cerevisiae. [PDF]
Wu Y +8 more
europepmc +1 more source
The continuing significance of chiral agrochemicals
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
Investigation of Non-<i>Saccharomyces</i> Yeasts for Developing Unique Flavor Profiles in Nonalcoholic Mulberry Fermented Beverage. [PDF]
Kerdkhong C +8 more
europepmc +1 more source
Contribution of Saccharomyces and Non-Saccharomyces Yeasts on the Volatile and Phenolic Profiles of Rosehip Mead. [PDF]
Avîrvarei AC +10 more
europepmc +1 more source

