Results 81 to 90 of about 1,110,814 (176)

Mapping genetic interactions in cancer: a road to rational combination therapies. [PDF]

, 2019
The discovery of synthetic lethal interactions between poly (ADP-ribose) polymerase (PARP) inhibitors and BRCA genes, which are involved in homologous recombination, led to the approval of PARP inhibition as a monotherapy for patients with BRCA1/2 ...
Krogan, Nevan J, Tutuncuoglu, Beril
core  

Screening families of patients with premature coronary heart disease to identify avoidable cardiovascular risk: a cross-sectional study of family members and a general population comparison group [PDF]

, 2010
<b>Background:</b> Primary prevention should be targeted at individuals with high global cardiovascular risk, but research is lacking on how best to identify such individuals in the general population.
Alastair CH Pell, Clara K Chow, Department of Health, DL Sackett, ET Hawe, G De Backer, Helen J Thompson, J De Sutter, Jill P Pell, JK Allen, Judith Anderson, K Leander, KD Lawson, P Jousilahti, SIGN Guidelines 97, T Kavanagh   +15 more
core   +2 more sources

Screening programme 2014: Phosphites, selected PBT substances and non-target screening

, 2015
The occurrence and environmental risk of a number of phosphites and selected PBT substances are reported for wastewater effluents and leachates, as well as sediments and biota from Oslofjord and Lake Mjøsa. In addition a suspect and non-target screening approach was applied to approximatley half of the biota samples.
Thomas, Kevin, Schlabach, Martin, Langford, Katherine, Reid, Malcolm, Fjeld, Eirik, Øxnevad, Sigurd, Rundberget, Thomas, Bæk, Kine, Rostkowski, Pawel, Röhler, Laura, Borgen, Anders   +10 more
openaire   +2 more sources

Evaluation of volatile safety in children's play mats based on non-targeted screening and risk prioritization

Ecotoxicology and Environmental Safety
Given the widespread use of play mats and their close contact with children, it is crucial to identify potential chemical hazards associated with these products.
Shuang Liang, Haoyang Shi, Yinhui Yang, Qing Zhang, Zhijuan Wang, Qing Lv   +5 more
doaj   +1 more source

Potentially inappropriate prescribing in nursing home residents detected with the community pharmacist specific GheOP3S-tool [PDF]

, 2016
Background: The Ghent Older People’s Prescriptions community Pharmacy Screening (GheOP3S-)tool was recently developed to screen for potentially inappropriate prescribing (PIP).
Boussery, Koen, Mattelin, Kristof, Mehuys, Els, PATTYN, EVA, Petrovic, Mirko, Somers, Annemie, Tommelein, Eline, Van Damme, Charlotte   +7 more
core   +1 more source

Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets. [PDF]

, 2017
BackgroundLiposarcoma, the most common soft tissue tumor, is understudied cancer, and limited progress has been made in the treatment of metastatic disease.
Doan, Ngan B, Forscher, Charles, Garg, Manoj, Kanojia, Deepika, Koeffler, H Phillip, Luty, Samuel B, M T, Anand, Martinez, Jacqueline, Said, Jonathan W, Tyner, Jeffrey W   +9 more
core   +2 more sources

Impact of a national HPV vaccination programme for preadolescent girls on cytology screening performance and CIN2+ incidence: five-year population-based cervical screening results from SloveniaResearch in context

The Lancet Regional Health. Europe
Summary: Background: HPV vaccination is most efficacious in preventing cervical cancer and its precursors when administered during preadolescence. Because in Slovenia women are invited for cytology screening from age 20, women targeted for preadolescent
Abyan Irzaldy, Tine Jerman, Inge M.C.M. de Kok, Jan A.C. Hontelez, Harry J. de Koning, Erik E.L. Jansen, Urška Ivanuš   +6 more
doaj   +1 more source

Barriers to cervical cancer screening: a cross-sectional study of non-adherent Portuguese women

BMC Primary Care
Background Cervical cancer is preventable through effective screening programmes, yet adherence remains suboptimal in Portugal. This study aimed to explore the reasons for non-adherence to cervical cancer screening, including socio-demographic influences
Joana Margarida Costa, Ana Luís Pimentel, Inês Duarte, Ana Cristina Moreira, Joana Isabel Santos, Isabel Nazaré, Paulo Santos   +6 more
doaj   +1 more source

Elucidation of chemicals of emerging concern in placenta by non-targeted and suspect screening approaches

Emerging Contaminants
Over the past century, anthropic activities in industrialized countries have generated exposure to a vast array of environmental chemical families. Many of these may have harmful effects on human health, and xenobiotic exposure during the fetal period is
A. Domínguez-Liste, L. Espín-Moreno, M.O. Schweiss, A. Rodríguez-Carrillo, V. Mustieles, M.F. Fernandez, J. Arrebola, C. Freire, O. Ballesteros, J. Pérez-del-Palacio, F. Vela-Soria   +10 more
doaj   +1 more source

Missed Opportunities for Diagnosing HIV via Routine Screening in an Inner- City Primary Care Clinic

Journal of the Georgia Public Health Association, 2015
Background: Although routine, opt-out HIV screening has been recommended for nearly a decade, clinical practice has not kept pace. Here, we examine missed opportunities for HIV screening among patients newly diagnosed with HIV via a routine non-targeted ...
Abigail Hankin, Sara Turbow, Jennifer Spicer, Heather Freiman, Bijal Shah, Natasha Travis   +5 more
doaj   +1 more source