Results 121 to 130 of about 212,876 (206)

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

How Advanced are Nanocarriers for Effective Subretinal Injection?

International Journal of Nanomedicine
Jia-Xin Guan,1,2 Yan-Ling Wang,1,2,* Jia-Lin Wang1,2,* 1Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Institute of Ophthalmology, Capital Medical University, Beijing ...
Guan JX, Wang YL, Wang JL
doaj  

Recent Advances in Non-Viral Vectors for Gene Therapy and Gene Delivery: From Lipid Nanoparticles to Engineered Extracellular Vesicles. [PDF]

Pharmaceutics
Yang Y, Song T, Huang K, Huang H, Zhao M, Li Y.   +5 more
europepmc   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy. [PDF]

Molecules, 2020
Wahane A, Waghmode A, Kapphahn A, Dhuri K, Gupta A, Bahal R.   +5 more
europepmc   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Advances in Nanoparticles as Non-Viral Vectors for Efficient Delivery of CRISPR/Cas9. [PDF]

Pharmaceutics
Kim M, Hwang Y, Lim S, Jang HK, Kim HO.
europepmc   +1 more source

Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors. [PDF]

J Nanobiotechnology, 2020
Ma XX, Xu JL, Jia YY, Zhang YX, Wang W, Li C, He W, Zhou SY, Zhang BL.   +8 more
europepmc   +1 more source

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Amino-Functionalized Poly(2-Ethyl-2-Oxazoline)-Ran-Poly[2-(3-Butenyl)-2-Oxazoline] Copolymers Used as Non-Viral Vectors for Nucleic Acid Delivery: Impact of Polymer Structure and Composition. [PDF]

Polymers (Basel)
Hristova D, Oleszko-Torbus N, Petrova M, Kowalczuk A, Ugrinova I, Rangelov S, Haladjova E.   +6 more
europepmc   +1 more source