Results 181 to 190 of about 212,876 (206)

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

The Role of Wildlife and Climate Change in the Emergence of One Health-Related Viral Diseases in Australia. [PDF]

Viruses
Ali MW, Hosen ME, Rahaman MM, Kinobe R, Jelocnik M, Sarker S.   +5 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

A review of genetic modification for ex vivo cellular therapies. [PDF]

Transfusion
Dinh A, Zhang N, Stroncek D.
europepmc   +1 more source

<i>In vivo</i> CAR T-cell generation: delivery platforms, clinical progress, and translational barriers. [PDF]

Front Immunol
Huo T, Yao H, Kong Z.
europepmc   +1 more source

Advances in the application of recombinant herpesvirus-vectored vaccines in animal disease control. [PDF]

Front Microbiol
Guo J, Mei C, Sun X, Lin Q, Bu W, Xie S, Jiang B.   +6 more
europepmc   +1 more source

Gene-based immunotherapy in osteosarcoma: from oncolytic vectors to engineered immune cells. [PDF]

Front Immunol
Jia J, Xie W, Zhou J, Wu W, Zhou S.
europepmc   +1 more source

Bicistronic Lentiviral Architecture Increases Surface Density of Membrane-Associated HIV Entry Inhibitors and Confers Tropism-Independent Protection to Modified Cells. [PDF]

Cells
Chervyakova YV, Smirnova AV, Siniavin AE, Soldatova VE, Gamzik DD, Tvorogova AV, Nakastoev IM, Filatov AV, Kruglova NA, Maslennikova AKY.   +9 more
europepmc   +1 more source

Highly efficient intranasal H5N1 vaccine based on a safe vesicular stomatitis virus (VSV) vector. [PDF]

Signal Transduct Target Ther
Liang Z, Zhang M, Zhang J, Chen H, Chen J, Tang C, Tong J, Wu X, Liu S, Nie L, Li Q, Nie J, Lu S, Huang W, Wang Y.   +14 more
europepmc   +1 more source