Results 171 to 180 of about 224,829 (339)

Discovery and validation of the tumor-suppressive function of long noncoding RNA PANDA in human diffuse large B-cell lymphoma through the inactivation of MAPK/ERK signaling pathway

, 2017
Yingjun Wang, Mingzhi Zhang, Huanan Xu, Yifei Wang, Zhaoming Li, Yu Chang, Xinhuan Wang, Xiaorui Fu, Zhi‐Yuan Zhou, Siyuan Yang, Bei Wang, Yufeng Shang   +11 more
openalex   +2 more sources

Identification of a De Novo MAGEL2 Pathogenic Variant in Schaaf–Yang Syndrome and the Importance of Paternal Allele Confirmation

Journal of Clinical Laboratory Analysis, EarlyView.
This study reports a de novo MAGEL2 pathogenic variant in a patient with Schaaf–Yang syndrome, confirmed through methylation‐sensitive analysis. Combining genomic sequencing with methylation assays helps accurately determine the parental origin of MAGEL2 mutations.
Youn‐Ji Hong, Misun Yang, Hyeon Jeong Kwon, Jooyoung Cha, Ja‐Hyun Jang, Sung Eun Wang, Eun Sun Lee, Mi‐Ae Jang   +7 more
wiley   +1 more source

Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma [Retraction]

, 2021
Jinghua Fan, Xiaoxiao Kang, Limin Zhao, Yan Zheng, Jun Yang, Di Li   +5 more
openalex   +2 more sources

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Human Breast Milk‐Derived Exosomal FP671120.4 Inhibits Macrophage M1 Polarization via Modulating the ELAVL1/Nrf2 Axis in Sepsis‐Associated Liver Injury

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐associated liver injury (SALI) plays a major role in aggravating disease progression and worsening prognosis in patients with sepsis. Macrophage polarization is a key factor in the modulation of SALI progression. Recent studies have shown that human breast milk‐derived exosomes (HBM‐Exos) regulate processes involved in macrophage ...
Zhao‐Bin Yang, Yi‐Bin Gao, Xiao‐Mei Cheng, Lu‐Zhen Qiu   +3 more
wiley   +1 more source

YBX1 regulation of alveolar type II epithelial cells in idiopathic pulmonary fibrosis: mechanistic insights and small-molecule drug screening

Journal of Translational Medicine
Background This study aims to systematically elucidate the molecular mechanisms underlying idiopathic pulmonary fibrosis (IPF), with a specific focus on the regulatory role of the nucleic acid-binding protein Y-box binding protein 1 (YBX1) in alveolar ...
Yijie He, Jin Li, Yibo Xie, Yaming Wu, Li Wang, Jungang Ren, Zhiqiang Zhang, Tong Yu, Shuxia Jiang, Hongli Shan, Yun Wu, Yuhong Zhou   +11 more
doaj   +1 more source

TET3‐Mediated m5C Modification of CCAT2 Accelerates Cardiac Microvascular Endothelial Cell Damage in Acute Coronary Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute coronary syndrome (ACS) is a clinical syndrome involving myocardial ischemia. This study aimed to elucidate the mechanism of TET3 in ACS‐induced CMEC damage, thereby identifying a new target for ACS treatment. The expression of TET3 in ACS patients and healthy subjects was analyzed.
Jun‐Cheng Liu, Wen‐Juan Wang, Ting‐Ting Zhang, Qi‐Chong Yang, Haliminai Dilimulati, Song‐Tao An   +5 more
wiley   +1 more source

Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity [PDF]

, 2022
Dominic Santoleri, Hee‐Woong Lim, Matthew J. Emmett, Julian Stoute, Matthew Gavin, Jaimarie Sostre‐Colón, Kahealani Uehara, Jaclyn E. Welles, Kathy Fange Liu, Mitchell A. Lazar, Paul M. Titchenell   +10 more
openalex   +1 more source

Circ_0006174 Drives Triple Negative Breast Cancer Progression and Immune Escape Through Regulating miR‐3139/PD‐L1 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is characterized as an aggressive malignancy with limited therapeutic options. The circular RNA circ_0006174 has been implicated in oncogenic processes across various cancers; however, its specific role in the pathogenesis of TNBC remains unclear.
Yong‐Zhe Tang, Li Yang, Ling Wang, Xiao‐Qing Zhang, Jie Wang   +4 more
wiley   +1 more source

GENE-03. SERUM LONG NONCODING RNA HOTAIR AS NOVEL DIAGNOSTIC AND PROGNOSTIC BIOMARKER IN GLIOBLASTOMA MULTIFORME [PDF]

, 2017
Sze Kiat Tan, Chiara Pastori, Clara Penas, Jann N. Sarkaria, Ricardo J. Komotar, Nagi G. Ayad   +5 more
openalex   +1 more source