Results 51 to 60 of about 224,829 (339)
Roles and mechanisms of CircRNAs in ovarian cancer
Frontiers in Cell and Developmental Biology, 2022 Ovarian cancer (OC) is one of the female malignancies with nearly 45% 5-year survival rate. Circular RNAs (circRNAs), a kind of single-stranded non-coding RNAs, are generated from the back-splicing of cellular housekeeping noncoding RNAs and precursor ...
Min Liu +10 more
doaj +1 more source
Noncoding RNAs database (ncRNAdb) [PDF]
Nucleic Acids Research, 2007 The noncoding RNA database (ncRNAdb) was created as a source of information on RNA molecules, which do not possess protein-coding capacity. It is now widely accepted that, in addition to constitutively expressed, housekeeping or infrastructural RNAs, there is a wide variety of RNAs participating in mechanisms involved in regulation of gene expression ...
Szymanski, Maciej +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2018 Circular non-coding RNAs are found to play important roles in biology but are still relatively unexplored as a structural motif for chemically regulating gene function. Here, we investigated whether small interfering RNA (siRNA) with a circular structure
Liangliang Zhang +8 more
doaj +1 more source
MicroRNA Profiling in Paired Left and Right Eyes, Lungs, and Testes of Normal Mice
Molecular Therapy: Nucleic Acids, 2020 Physiological and pathophysiological differences widely exist in paired organ systems. However, the molecular basis for these differences remains largely unknown.
Jiangcheng Shi +5 more
doaj +1 more source
EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs. [PDF]
, 2018 BackgroundPolycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development and diseases in numerous systems.
He, Yuan +9 more
core
Long non-coding RNAs era in liver cancer [PDF]
, 2015 Hepatocellular carcinoma (HCC) is one of the most common malignancies leading to high mortality rates in the general population and the sixth most common cancer worldwide.
Guerrieri, Francesca
core +1 more source
Long noncoding RNA: noncoding and not coded [PDF]
Cell Death Discovery, 2017 Mammalian evolution exhibits extraordinary acceleration in phenotypic complexity while displaying genetic conservation. Indeed, protein-coding genes are 90% identical between mice and human, and the question arises what might be the mechanisms by which phenotypic complexity increases while the number of proteins does not?
Toiber, Debra +2 more
openaire +2 more sources
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
BMC Bioinformatics, 2019 Background 2′-O-methylation (2′-O-me or Nm) is a post-transcriptional RNA methylation modified at 2′-hydroxy, which is common in mRNAs and various non-coding RNAs. Previous studies revealed the significance of Nm in multiple biological processes. With Nm
Yiran Zhou, Qinghua Cui, Yuan Zhou
doaj +1 more source