Results 91 to 100 of about 10,782 (215)

[Biologically active nonribosomal peptides. II. Nonribosomal peptides of various biological action].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2012
The second part of the review concerned with investigation of nonribosomal peptides.
T. I. Orlova, V. G. Bulgakova, A. N. Polin   +2 more
openaire   +2 more sources

rBAN: retro-biosynthetic analysis of nonribosomal peptides [PDF]

Journal of Cheminformatics, 2019
Proteinogenic and non-proteinogenic amino acids, fatty acids or glycans are some of the main building blocks of nonribsosomal peptides (NRPs) and as such may give insight into the origin, biosynthesis and bioactivities of their constitutive peptides.
Emma Ricart, Valérie Leclère, Areski Flissi, Markus Müller 0006, Maude Pupin, Frédérique Lisacek   +5 more
openaire   +7 more sources

Engineering Fungal Nonribosomal Peptide Synthetase-like Enzymes by Heterologous Expression and Domain Swapping

, 2016
A facile genetic methodology in the filamentous fungus Aspergillus nidulans allowed the exchange of various domains in nonribosomal peptide synthase (NRPS)-like enzymes from Aspergillus terreus.
Clay C. C. Wang (313310), Johannes W. A. van Dijk (3384221), Chun-Jun Guo (401559)   +2 more
core   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, Volume 3, Issue 2, June 2026.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

Virulence, Host-Selective Toxin Production, and Development of Three Cochliobolus Phytopathogens Lacking the Sfp-Type 4′-Phosphopantetheinyl Transferase Ppt1

Molecular Plant-Microbe Interactions, 2015
The Sfp-type 4′-phosphopantetheinyl transferase Ppt1 is required for activation of nonribosomal peptide synthetases, including α-aminoadipate reductase (AAR) for lysine biosynthesis and polyketide synthases, enzymes that biosynthesize peptide and ...
Nur Ain Izzati Mohd Zainudin, Bradford Condon, Lieselotte De Bruyne, Christof Van Poucke, Qing Bi, Wei Li, Monica Höfte, B. Gillian Turgeon   +7 more
doaj   +1 more source

Mining the Yucatan Coastal Microbiome for the Identification of Non-Ribosomal Peptides Synthetase (NRPS) Genes

Toxins, 2020
Prokaryotes represent a source of both biotechnological and pharmaceutical molecules of importance, such as nonribosomal peptides (NRPs). NRPs are secondary metabolites which their synthesis is independent of ribosomes.
Mario Alberto Martínez-Núñez, Zuemy Rodríguez-Escamilla   +1 more
doaj   +1 more source

Pyoverdine Plays Only a Minor, Strain‐Specific Role in the Inhibition of Phytophthora infestans by Pseudomonas Strains

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Pseudomonas strains R32 and R47 inhibit Phytophthora infestans, which causes late blight in potato. To assess the importance of pyoverdine, a high‐affinity siderophore both strains produce, in P. infestans inhibition, we produced pyoverdine‐deficient mutants and tested their antagonistic activity at different developmental stages of the pathogen ...
Livia Jerjen, Floriane L'Haridon, Laure Weisskopf   +2 more
wiley   +1 more source

Structural and Functional Insights into a Peptide Bond-Forming Bidomain from a Nonribosomal Peptide Synthetase

, 2007
SummaryThe crystal structure of the bidomain PCP-C from modules 5 and 6 of the nonribosomal tyrocidine synthetase TycC was determined at 1.8 Å resolution.
Marahiel, Mohamed A., Samel, Stefan A., Schoenafinger, Georg, Essen, Lars-Oliver, Knappe, Thomas A.   +4 more
core   +1 more source

Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains

Current Research in Structural Biology, 2020
The recently discovered antibiotic teixobactin is produced by uncultured soil bacteria. The antibiotic inhibits cell wall synthesis of Gram-positive bacteria by binding to precursors of cell wall building blocks, and therefore it is thought to be less ...
Kemin Tan, Min Zhou, Robert P. Jedrzejczak, Ruiying Wu, Raul A. Higuera, Dominika Borek, Gyorgy Babnigg, Andrzej Joachimiak   +7 more
doaj   +1 more source

A Complete Genome Resource and Bio‐Control Activity of Soil‐Isolated Pseudomonas citronellolis Strain M03 Against Onion‐Pathogenic Burkholderia Species

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Pseudomonas citronellolis M03, isolated from field soil, was sequenced and its genome revealed ten biosynthetic clusters, including siderophore NRPS. Phenotypic assays showed strong antagonism against onion‐pathogenic Burkholderia spp., reducing B.
Kephas Mphande, Michelle Pena MacLellan, Anoop Anand Malik, Bhabesh Dutta   +3 more
wiley   +1 more source