Results 81 to 90 of about 10,782 (215)
Hydrobiology, 2023 Streptomyces sp. N11-50 was isolated from deep-sea water and found to produce diketopiperazine (DKP) compounds such as albonoursin and cyclo(Phe-Leu).
Hisayuki Komaki +2 more
doaj +1 more source
Crystal Structure and Conformational Dynamics of N─N Bond‐Forming Piperazate Synthase
ChemBioChem, Volume 27, Issue 12, 26 June 2026.Piperazate synthases (PZSs) catalyze the key N─N bond formation in the biosynthesis of the rare amino acid piperazic acid. X‐ray crystal structures of apo‐ and holo‐SbPZS show a dimeric enzyme with two heme‐containing active sites, where histidine residues coordinate the iron centers.
Nikita Pal +7 more
wiley +1 more source
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2013 The third part of the review is concerned with investigation of nonribosomal peptides.
T. I. Orlova +2 more
openaire +2 more sources
Norine: A powerful resource for novel nonribosomal peptide discovery
Synthetic and Systems Biotechnology, 2016 Since its first release in 2008, Norine remains the unique resource completely devoted to nonribosomal peptides (NRPs). They are very attractive microbial secondary metabolites, displaying a remarkable diversity of structure and functions. Norine (http://
M. Pupin +5 more
doaj +1 more source
Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery
Nature Communications, 2021 Current genome mining methods predict many putative non-ribosomal peptides (NRPs) from their corresponding biosynthetic gene clusters, but it remains unclear which of those exist in nature and how to identify their post-assembly modifications.
Bahar Behsaz +15 more
doaj +1 more source
Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami +2 more
wiley +1 more source
Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst
, 2016 A protease from ribosomal peptide biosynthesis macrocyclizes diverse substrates, including those resembling nonribosomal peptide and hybrid polyketide−peptide products.
Charles R. Robertson (2253277) +5 more
core +1 more source
Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis
, 2022 Dehydroamino acids are important structural motifs and biosynthetic intermediates for natural products. Many bioactive natural products of nonribosomal origin contain dehydroamino acids; however, the biosynthesis of dehydroamino acids in most ...
Kamal Adhikari (9334450) +8 more
core +1 more source
Delftibactin-A, a Non-ribosomal Peptide With Broad Antimicrobial Activity
Frontiers in Microbiology, 2019 The rapid emergence of drug resistant bacteria is occurring worldwide, outpacing the development of new antibiotics. It is known that some of the main sources of antibiotics are the bacteria themselves, many of which are secondary metabolites of Gram ...
Noa Tejman-Yarden +10 more
doaj +1 more source
Structural basis of nonribosomal peptide macrocyclization in fungi [PDF]
Nature Chemical Biology, 2016 Nonribosomal peptide synthetases (NRPSs) in fungi biosynthesize important pharmaceutical compounds, including penicillin, cyclosporine and echinocandin. To understand the fungal strategy of forging the macrocyclic peptide linkage, we determined the crystal structures of the terminal condensation-like (CT) domain and the holo thiolation (T)-CT complex ...
Jinru, Zhang +8 more
openaire +2 more sources