Results 91 to 100 of about 8,685 (175)

Mechanistic Insights Into the Biosynthesis of Pseurotin A in Aspergillus fumigatus

Small Structures
The biosynthesis of pseurotin A, a fungal metabolite with antibiotic and immunosuppressive properties, involves a group of enzymes, including a polyketide‐nonribosomal peptide synthase (PKS‐NRPS), PsoA, and a bifunctional enzyme, PsoF. PsoA consists of a
Lei Sun, Zi‐Long You, Rui‐Qing Lyu, Zhao‐Bin Wang, Ming Ma, Lin Bai   +5 more
doaj   +1 more source

Cell-free protein synthesis for nonribosomal peptide synthetic biology

Frontiers in Natural Products
Peptide natural products have a wide range of useful applications as pesticides, veterinary agents, pharmaceuticals, and bioproducts. To discover new natural products, manipulate them for analog generation, and to harness the potential of these bioactive
Tien T. Sword, Ghaeath S. K. Abbas, Constance B. Bailey   +2 more
doaj   +1 more source

Biosynthesis of the antibiotic nonribosomal peptide penicillin in baker’s yeast

Nature Communications, 2017
Filamentous fungi are a valuable source of natural therapeutic products such as antibiotics. Here the authors engineer monocellularS. cerevisiaeto perform complex secondary metabolism typical of multicellular fungi in order to demonstrate biosynthesis ...
Ali R. Awan, Benjamin A. Blount, David J. Bell, William M. Shaw, Jack C.H. Ho, Robert M. McKiernan, Tom Ellis   +6 more
doaj   +1 more source

PARAS: High-Accuracy Machine Learning of Substrate Specificities in Nonribosomal Peptide Synthetases. [PDF]

JACS Au
Terlouw BR, Huang C, Meijer D, Cediel-Becerra JDD, He R, Rothe ML, Jenner M, Zhou S, Zhang Y, Fage CD, Tsunematsu Y, van Wezel GP, Robinson SL, Alberti F, Alkhalaf LM, Chevrette MG, Challis GL, Medema MH.   +17 more
europepmc   +2 more sources

Nonribosomal peptide synthetases

, 2018
Nonribosomal peptide synthetases or NRPS, are extraordinarily large, modular and complex molecular machines responsible for the production of important bioactive compounds, such as antibiotics, anti-cancer drugs as well as pigments, among many others. Even though it has become increasingly simple to identify and partially classify this kind of enzyme ...
openaire   +1 more source

Guidelines for Optimizing Type S Nonribosomal Peptide Synthetases. [PDF]

ACS Synth Biol, 2023
Abbood N, Effert J, Bozhueyuek KAJ, Bode HB.   +3 more
europepmc   +1 more source

Charting the Biosynthetic Landscape of Hybrid Polyketide-Nonribosomal Peptide-Specialized Lipids. [PDF]

JACS Au
El Arnouki Belhaji F, De Ruysscher D, Vanreppelen G, Huybrechts LL, Alanjary MM, Zdouc MM, de Los Santos ELC, Demaerel J, Vaneeckhaute E, Van Goethem O, Gerstmans H, Breynaert E, Van Dijck P, Medema MH, Weir ANM, Lescrinier E, Masschelein J.   +16 more
europepmc   +1 more source

Identification of the lipodepsipeptide selethramide encoded in a giant nonribosomal peptide synthetase from a Burkholderia bacterium. [PDF]

Proc Natl Acad Sci U S A, 2023
Romanowski SB, Lee S, Kunakom S, Paulo BS, Recchia MJJ, Liu DY, Cavanagh H, Linington RG, Eustáquio AS.   +8 more
europepmc   +1 more source

Paenitracins, a novel family of bacitracin-type nonribosomal peptide antibiotics produced by plant-associated <i>Paenibacillus</i> species. [PDF]

mSystems
Machushynets NV, Elsayed SS, Du C, Lysenko V, de la Cruz M, Sanchez P, Genilloud O, Martin NI, Liles MR, van Wezel GP.   +9 more
europepmc   +1 more source

Structural Basis for a Scaffolding Role of the COM Domain in Nonribosomal Peptide Synthetases. [PDF]

Angew Chem Int Ed Engl
Diecker J, Hermanns B, Rüschenbaum J, Rasche R, Dörner W, Schröder A, Kümmel D, Mootz HD.   +7 more
europepmc   +1 more source