Results 81 to 90 of about 8,685 (175)

Mining the Yucatan Coastal Microbiome for the Identification of Non-Ribosomal Peptides Synthetase (NRPS) Genes

open access: yesToxins, 2020
Prokaryotes represent a source of both biotechnological and pharmaceutical molecules of importance, such as nonribosomal peptides (NRPs). NRPs are secondary metabolites which their synthesis is independent of ribosomes.
Mario Alberto Martínez-Núñez   +1 more
doaj   +1 more source

Deciphering the Function and Structure of PA1216 as an S‐Adenosyl‐l‐Methionine Binding Protein Using Differential Scanning Fluorimetry and Circular Dichroism

open access: yesProtein Science, Volume 35, Issue 8, August 2026.
Abstract Microbes produce bioactive secondary metabolites as toxins, pigments, or virulence factors. These specialized compounds are produced by nonribosomal peptide synthetases (NRPS), polyketide synthases (PKS), or hybrid NRPS/PKS pathways. The genes encoding NRPS and PKS reside in biosynthetic gene clusters (BGCs), some of which have no identified ...
Amaan M. Fruitwala   +4 more
wiley   +1 more source

Virulence, Host-Selective Toxin Production, and Development of Three Cochliobolus Phytopathogens Lacking the Sfp-Type 4′-Phosphopantetheinyl Transferase Ppt1

open access: yesMolecular Plant-Microbe Interactions, 2015
The Sfp-type 4′-phosphopantetheinyl transferase Ppt1 is required for activation of nonribosomal peptide synthetases, including α-aminoadipate reductase (AAR) for lysine biosynthesis and polyketide synthases, enzymes that biosynthesize peptide and ...
Nur Ain Izzati Mohd Zainudin   +7 more
doaj   +1 more source

Structures of teixobactin-producing nonribosomal peptide synthetase condensation and adenylation domains

open access: yesCurrent Research in Structural Biology, 2020
The recently discovered antibiotic teixobactin is produced by uncultured soil bacteria. The antibiotic inhibits cell wall synthesis of Gram-positive bacteria by binding to precursors of cell wall building blocks, and therefore it is thought to be less ...
Kemin Tan   +7 more
doaj   +1 more source

Beneath the Bark: Molecular Determinants of Adaptation and Infection in Bacterial Pathogens of Woody Hosts

open access: yesMolecular Plant Pathology, Volume 27, Issue 8, August 2026.
Bacterial pathogens colonise woody hosts by integrating metabolic adaptation, effector‐mediated immune suppression, cell wall remodelling and EPS‐ and toxin‐supported persistence. ABSTRACT Bacterial pathogens of woody plants represent a pervasive yet underexplored threat to global agriculture and forestry, causing devastating diseases in fruit trees ...
Antonio Arroyo‐Mateo   +3 more
wiley   +1 more source

Aspergillus hancockii sp. nov., a biosynthetically talented fungus endemic to southeastern Australian soils.

open access: yesPLoS ONE, 2017
Aspergillus hancockii sp. nov., classified in Aspergillus subgenus Circumdati section Flavi, was originally isolated from soil in peanut fields near Kumbia, in the South Burnett region of southeast Queensland, Australia, and has since been found ...
John I Pitt   +11 more
doaj   +1 more source

Plastic Diets Drive Microbiome and Metabolic Reprogramming in Wax Moth Larvae (Achroia grisella)

open access: yesArchives of Insect Biochemistry and Physiology, Volume 122, Issue 3, July 2026.
Wax moth larvae (Achroia grisella) can consume LDPE and PLA, triggering polymer‐specific restructuring of the gut microbiome and host metabolism. LDPE feeding enriches Bacillus spp. and is associated with shifts in carbohydrate and amino‐acid pathways consistent with hydrocarbon processing, whereas PLA feeding enriches Enterococcus spp.
Rohan Shah   +9 more
wiley   +1 more source

Genomic and Functional Characterization of Sunflower Endophytes Reveals Mechanisms of Drought Tolerance and Growth Promotion

open access: yesPlant Direct, Volume 10, Issue 7, July 2026.
ABSTRACT Drought severely limits sunflower (Helianthus annuus L.) productivity, necessitating sustainable microbial strategies to enhance plant resilience. Endophytic bacteria modulate plant stress responses through diverse plant growth‐promoting (PGP) traits.
Muritala Muhammed   +2 more
wiley   +1 more source

Draft genome sequence of a human-associated isolate of Haloferax alexandrinus strain Arc-hr, an extremely halophilic archaea

open access: yesNew Microbes and New Infections, 2017
We report the draft genome sequence of Haloferax alexandrinus strain Arc-hr (CSUR P798), isolated from the human gut of a 10-year-old Amazonian individual. Its 3 893 626 bp genome exhibits a 66.00% GC content.
S. Khelaifia   +3 more
doaj   +1 more source

Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection.

open access: yesPLoS Pathogens, 2007
Siderophore biosynthesis by the highly lethal mould Aspergillus fumigatus is essential for virulence, but non-existent in humans, presenting a rare opportunity to strategize therapeutically against this pathogen.
Markus Schrettl   +9 more
doaj   +1 more source

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